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31.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TRYPTOPHANYL-TRNA SYNTHETASES 有权与TRYPTOPHANYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130330312A1
公开(公告)日：2013-12-12
申请号：US13877899
申请日：2011-10-06
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00
CPC classification number: C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/92 , C12Y601/01
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20130280230A1
公开(公告)日：2013-10-24
申请号：US13809750
申请日：2011-07-11
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00
CPC classification number: C07K16/40 , A61K38/00 , A61K38/53 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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33.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASES 有权与甲硫氨酸合成酶蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130236440A1
公开(公告)日：2013-09-12
申请号：US13696044
申请日：2011-05-03
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US07833755B2
公开(公告)日：2010-11-16
申请号：US12470753
申请日：2009-05-22
Applicant: Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
Inventor： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
CPC classification number: C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20090239258A1
公开(公告)日：2009-09-24
申请号：US12470753
申请日：2009-05-22
Applicant: Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
Inventor： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
CPC classification number: C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。
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Patent Agency Ranking
公开(公告)号：US20090202986A1
公开(公告)日：2009-08-13
申请号：US11577061
申请日：2004-10-28
Applicant: William D. Huse , Jeffry Dean Watkins , Alain Philippe Vasserot , David Matthew Marquis , Eric Michael Smith
Inventor： William D. Huse , Jeffry Dean Watkins , Alain Philippe Vasserot , David Matthew Marquis , Eric Michael Smith
IPC: C12Q1/68
CPC classification number: C07K16/2878 , C07K16/36 , C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/92
Abstract: The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments.
Abstract translation: 本发明提供了优化的异源可变区结合片段和包含优化的异聚可变区结合片段的抗体。 优选地，优化的异聚可变区结合片段与供体异聚体可变区相比表现出优化的活性并且具有不变的人框架。 本发明还提供了制备优化的异源可变区结合片段的方法。
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公开(公告)号：US07541033B2
公开(公告)日：2009-06-02
申请号：US10542508
申请日：2004-01-21
Applicant: Craig Duane Dickinson , Alain Philippe Vasserot , Jeffry Dean Watkins , Jirong Lu
Inventor： Craig Duane Dickinson , Alain Philippe Vasserot , Jeffry Dean Watkins , Jirong Lu
IPC: C07K16/00 , C07K16/24 , C12P21/08 , A61K39/395 , A61K39/00
CPC classification number: C07K16/245 , A61K2039/505 , C07K2317/565
Abstract: The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
Abstract translation: 本发明包括与成熟的人IL-1β特异性结合的分离的抗体或其抗原结合部分。 与天然抗体相比，这些抗体或其抗原结合部分通常表现出高的结合亲和力（低kooff值），减少的脱酰胺化，并且可以用于治疗各种疾病如类风湿性关节炎，骨关节炎或神经炎症。
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公开(公告)号：US07479271B2
公开(公告)日：2009-01-20
申请号：US11815379
申请日：2006-02-09
Applicant: David Matthew Marquis , Alain Philippe Vasserot , Derrick Ryan Witcher
Inventor： David Matthew Marquis , Alain Philippe Vasserot , Derrick Ryan Witcher
IPC: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC classification number: C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
Abstract: Humanized antibodies, or antigen-binding portions thereof, that preferentially bind acylated ghrelin with respect to unacylated ghrelin, are disclosed. These molecules have high affinity and a slow off rate for acylated ghrelin, and neutralize acylated ghrelin activity. These antibodies, or antigen-binding portions thereof, are useful for neutralizing acylated ghrelin activity, e.g., in a subject suffering from a disorder in which ghrelin activity is detrimental, such as obesity.
Abstract translation: 公开了相对于未酸化的生长素释放肽优先结合酰化的生长素释放肽的人源化抗体或其抗原结合部分。 这些分子对酰化的生长素释放肽具有高亲和力和缓慢的速率，并中和酰化的生长素释放肽活性。 这些抗体或其抗原结合部分可用于中和酰化的生长素释放肽活性，例如在患有生长素释放肽活性是有害的疾病如肥胖症的受试者中。
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39.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex 有权与p38多tRNA合成酶复合物的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09062302B2
公开(公告)日：2015-06-23
申请号：US13696049
申请日：2011-05-04
Applicant: Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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40.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases 有权与Valyl-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09034320B2
公开(公告)日：2015-05-19
申请号：US13695229
申请日：2011-04-29
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry Dean Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K9/19 , A61K38/53 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01009 , G01N33/5011 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/10
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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