公开(公告)号：US20230377764A1

公开(公告)日：2023-11-23

申请号：US18164164

申请日：2023-02-03

申请人： The University of Chicago

发明人： Jeffrey A. HUBBELL ,  Jun ISHIHARA ,  Ako ISHIHARA ,  Kazuto FUKUNAGA ,  Melody SWARTZ

IPC分类号： G21F5/12 ,  A61P35/00 ,  A61K9/00 ,  A61K38/18 ,  A61K38/19 ,  A61K38/36 ,  A61K39/395 ,  A61K45/06 ,  C07K14/475 ,  C07K14/52 ,  C07K14/755 ,  C07K16/28 ,  G21F7/005

CPC分类号： G21F5/12 ,  A61P35/00 ,  A61K9/0019 ,  A61K38/18 ,  A61K38/195 ,  A61K38/36 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/475 ,  C07K14/522 ,  C07K14/755 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  G21F7/005 ,  A61K2039/507

摘要： The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

公开(公告)号：US20230340047A1

公开(公告)日：2023-10-26

申请号：US18151166

申请日：2023-01-06

申请人： Northwestern University

发明人： Hemant K. Roy ,  Vadim Backman

IPC分类号： C07K14/475 ,  A61K31/282 ,  C07K14/47

CPC分类号： C07K14/475 ,  A61K31/282 ,  C07K14/4703 ,  A61K38/00

摘要： Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.

公开(公告)号：US20230322951A1

公开(公告)日：2023-10-12

申请号：US18311306

申请日：2023-05-03

申请人： Silver Creek Pharmaceuticals, Inc.

发明人： Ulrik Bjerl Nielsen ,  Thomas Wickham ,  Birgit Schoeberl ,  Brian Harms ,  Bryan Linggi ,  Matthew Onsum ,  Byron DeLaBarre

IPC分类号： C07K16/46 ,  B82Y5/00 ,  C07K14/475 ,  C12N15/62 ,  A61K47/66 ,  A61K47/68 ,  A61K45/06 ,  C07K14/47 ,  C07K14/485 ,  C07K14/65 ,  C07K16/44

CPC分类号： C07K16/46 ,  B82Y5/00 ,  C07K14/475 ,  C12N15/62 ,  A61K47/66 ,  A61K47/6811 ,  A61K47/6891 ,  A61K45/06 ,  C07K14/47 ,  C07K14/485 ,  C07K14/65 ,  C07K16/44 ,  C07K2319/00 ,  A61K38/00

摘要： Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

公开(公告)号：US11773138B2

公开(公告)日：2023-10-03

申请号：US17506523

申请日：2021-10-20

申请人： Theradaptive, Inc.

发明人： Luis Alvarez

IPC分类号： C07K7/08 ,  C07K14/51 ,  C07K14/00 ,  A61P19/00 ,  C07K14/475 ,  A61K38/18 ,  A61K38/04 ,  A61K38/16

CPC分类号： C07K7/08 ,  A61K38/04 ,  A61K38/16 ,  A61K38/1875 ,  A61P19/00 ,  C07K14/001 ,  C07K14/475 ,  C07K14/51

摘要： Provided herein are polypeptides that include one or more β-tricalcium phosphate (βTCP)-binding sequence(s) and uses thereof.

公开(公告)号：US20230304038A1

公开(公告)日：2023-09-28

申请号：US18022059

申请日：2021-08-19

申请人： SAREPTA THERAPEUTICS, INC.

发明人： Colin O'BANION

IPC分类号： C12N15/86 ,  C07K14/475 ,  A61P25/00

CPC分类号： C12N15/86 ,  C07K14/475 ,  A61P25/00 ,  C12N2750/14143 ,  C12N2750/14171 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/50 ,  C12N2830/38 ,  A61K48/00

摘要： The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in the mecp2 gene, such as Rett Syndrome. Also, provided herein are methods for treating and/or delaying the onset of brain-derived neurotrophic factor (BDNF)-associated diseases.

公开(公告)号：US20230257436A1

公开(公告)日：2023-08-17

申请号：US18011647

申请日：2021-06-21

申请人： Johan Gunnarsson LUNDKVIST ,  Lars Ulrik WAHLBERG ,  Johan Henrik Biverstål

发明人： Johan Gunnarsson LUNDKVIST ,  Lars Ulrik WAHLBERG ,  Johan Henrik Biverstål

IPC分类号： C07K14/475 ,  G01N33/68 ,  C12P21/00 ,  C07K14/47 ,  A61K39/395 ,  A61P25/28

CPC分类号： C07K14/4756 ,  G01N33/6896 ,  C12P21/005 ,  C07K14/475 ,  C07K14/4705 ,  A61K39/3955 ,  A61P25/28 ,  G01N2800/2814 ,  G01N2333/4756 ,  C07K2319/00

摘要： A cell culture comprising a mammalian cell line which is modified to express a heterodimer consisting of a progranulin polypeptide and a prosaposin polypeptide.

公开(公告)号：US20230220041A1

公开(公告)日：2023-07-13

申请号：US18082857

申请日：2022-12-16

申请人： CREATIVE MEDICAL TECHNOLOGIES, INC.

发明人： Thomas Ichim ,  Amit Patel ,  Timothy Warbington

IPC分类号： C07K14/725 ,  C07K14/54 ,  C07K14/49 ,  C07K14/515 ,  C07K14/65 ,  C07K14/475 ,  C07K16/18 ,  A61K35/17

CPC分类号： C07K14/7051 ,  C07K14/5403 ,  C07K14/49 ,  C07K14/515 ,  C07K14/65 ,  C07K14/4753 ,  C07K16/18 ,  A61K35/17 ,  C07K2319/33 ,  C07K2319/02 ,  C07K2319/03 ,  A61K2039/5156

摘要： A method of creating antigen-specific, chimeric antigen receptor (CAR) T cells capable of secreting regenerative growth factors upon activation of said CAR. In one embodiment said regenerative CAR-T cells possess a CAR capable of selectively recognizing damaged tissue. In one embodiment said CAR recognizes damage-associated molecular patterns (DAMPs) such as ATP, HMGB-1, matricryptins, cold-inducible RNA-binding protein, histones and mitochondrial DNA. Upon activation of said CAR said regenerative CAR-T cell is induced to produce one or more regenerative growth factors. In some embodiments the invention provides a suicide gene in said regenerative CAR-T cells in order to remove said cells after their therapeutic purpose is completed.

公开(公告)号：US20230220027A1

公开(公告)日：2023-07-13

申请号：US18000724

申请日：2021-06-07

申请人： ORF LIFTAEKNI HF

发明人： Bjorn Larus ORVAR ,  Arna RUNARSDOTTIR ,  Jon Mar BJORNSSON ,  Hilmar VIDARSSON

IPC分类号： C07K14/475 ,  C07K14/425 ,  C12N15/82 ,  C12N5/077

CPC分类号： C07K14/475 ,  C07K14/425 ,  C12N15/8257 ,  C12N5/0658 ,  C12N2501/10

摘要： The invention relates to the use of a growth factor composition comprising one or more recombinant animal growth factor and one or more plant seed protein for cultivating cells for the production of cell culture meat. The invention also relates to a method of cultivating cells for the production of cell culture meat using a growth factor composition that comprises one or more recombinant animal growth factor and one or more plant seed protein.

公开(公告)号：US11673911B2

公开(公告)日：2023-06-13

申请号：US16791076

申请日：2020-02-14

申请人： Intellia Therapeutics, Inc.

发明人： Christian Dombrowski

IPC分类号： C12N15/11 ,  C07H21/02 ,  C12N15/63 ,  C07K14/475 ,  C07K14/52 ,  C12N9/22

CPC分类号： C07H21/02 ,  C12N15/11 ,  C12N15/63 ,  C07K14/475 ,  C07K14/521 ,  C12N9/22

摘要： This disclosure relates to the field of poly-adenylated (poly-A) tails. In some embodiments, a DNA encodes a poly-A tail located 3′ to nucleotides encoding a protein of interest, wherein the poly-A tail comprises one or more non-adenine nucleotide.

公开(公告)号：US11672870B2

公开(公告)日：2023-06-13

申请号：US16266535

申请日：2019-02-04

申请人： The University of Nottingham

发明人： James Dixon ,  Kevin Shakesheff ,  Chris Denning

IPC分类号： A61K31/726 ,  A61K31/727 ,  A61K38/17 ,  A61K39/395 ,  A61K47/64 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C12N15/63 ,  C07K14/475 ,  A61K39/00

CPC分类号： A61K47/645 ,  A61K31/726 ,  A61K31/727 ,  A61K38/177 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C12N15/63 ,  A61K2039/505 ,  C07K2319/01 ,  C07K2319/10 ,  C07K2319/20 ,  C07K2319/33

摘要： This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.