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274 条记录 (耗时 0.035 秒)

    Broad ion fragmentation coverage in mass spectrometry by varying the collision energy
    21.
    发明申请
    Broad ion fragmentation coverage in mass spectrometry by varying the collision energy 有权
    通过改变碰撞能量，质谱中的宽离子碎片覆盖

    公开(公告)号：US20040041090A1

    公开(公告)日：2004-03-04

    申请号：US10425190

    申请日：2003-04-28

    发明人： Nic Bloomfield ,  Yves LeBlanc

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/005 ,  H01J49/063

    摘要： In the field of mass spectrometry, a method of obtaining a mass spectrum enriched with fragment ions while retaining the precursor ion. The technique includes varying the collision energy experienced by the precursor ion such that a range of fragmentations occur. Related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectra which are enriched with fragment ions.

    摘要翻译： 在质谱领域中，获得富含碎片离子同时保留前体离子的质谱的方法。 该技术包括改变由前体离子所经历的碰撞能量，从而发生一定范围的碎裂。 还公开了用于获得富含碎片离子的MS，MS 2，MS 3和MS n谱的相关方法。

    Mass spectrometer
    22.
    发明申请
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US20040026610A1

    公开(公告)日：2004-02-12

    申请号：US10426827

    申请日：2003-05-01

    申请人： Micromass UK Limited

    发明人： Fadi Abou-Shakra ,  Andrew Eaton ,  Andrew Entwistle ,  Heather Walker

    IPC分类号： H01J049/00

    CPC分类号： H01J49/105

    摘要： An Inductively Coupled Plasma (nullICPnull) mass spectrometer is disclosed comprising a mass filter and a reaction/collision cell. Analyte ions and background ions having the same nominal mass to charge ratio are transmitted by the mass filter. The analyte ions selectively react with gas in the reaction/collision cell to form product ions having different mass to charge ratios. By measuring the intensity of the product ions the intensity of the analyte ions can be determined. According to less preferred embodiments background ions may be neutralised or reacted in the reaction/collision cell.

    摘要翻译： 公开了包括质量过滤器和反应/碰撞池的电感耦合等离子体（“ICP”）质谱仪。 具有相同标称质荷比的分析离子和背景离子通过质量过滤器传输。 分析物离子选择性地与反应/碰撞池中的气体反应形成具有不同质荷比的产物离子。 通过测量产物离子的强度，可以确定分析物离子的强度。 根据较不优选的实施方案，背景离子可以在反应/碰撞池中被中和或反应。

    Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
    24.
    发明申请
    Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring 有权
    使用激光解吸和多反应监测对小分子进行高通量定量的方法和系统

    公开(公告)号：US20030213901A1

    公开(公告)日：2003-11-20

    申请号：US10400322

    申请日：2003-03-27

    发明人： Thomas R. Covey ,  John J. Corr ,  William H. Fisher ,  Chau Tung

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/4215 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0481 ,  H01J49/164

    摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement sensitivity is obtained by applying laser pulses to the ion source at a high pulse rate of about 500 Hz or higher. This allows the data acquisition to be performed rapidly, and the speed of about one second for each sample point on the ion source target has been achieved.

    摘要翻译： 使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。 从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。 通过以大约500Hz或更高的高脉冲速度向离子源施加激光脉冲，可以获得显着提高的测量灵敏度。 这允许快速执行数据采集，并且已经实现了离子源目标上的每个采样点的约1秒的速度。

    Parallel plate geometry faims apparatus and method
    25.
    发明申请
    Parallel plate geometry faims apparatus and method 失效
    平板几何装置及方法

    公开(公告)号：US20030213899A9

    公开(公告)日：2003-11-20

    申请号：US10221480

    申请日：2002-09-13

    发明人： Roger Guevremont ,  Randy Purves

    IPC分类号： H01J049/00

    CPC分类号： G01N27/624

    摘要： A method and an apparatus is disclosed for selectively transmitting ions in which the ions are subjected to a focusing effect such that the overall efficiency of ion transmission is increased. The method relies on a FAIMS analyzer having at least an electrode disposed approximately between two other electrode surfaces for producing an electric field that is symmetric on opposing sides of the at least an electrode. An ion exiting from between the electrodes experiences a balanced electric field, such that impact with one of the electrodes is prevented.

    摘要翻译： 公开了一种用于选择性地透射离子的方法和装置，其中离子受到聚焦效应，使得离子透射的总体效率增加。 该方法依赖于FAIMS分析器，其至少具有设置在两个其它电极表面之间的电极，用于产生在至少一个电极的相对侧上对称的电场。 从电极之间离开的离子经历平衡的电场，从而防止与其中一个电极的冲击。

    Ion beam mass separation filter, mass separation method thereof and ion source using the same
    27.
    发明申请
    Ion beam mass separation filter, mass separation method thereof and ion source using the same 失效
    离子束质量分离过滤器，其质量分离方法和使用其的离子源

    公开(公告)号：US20030168588A1

    公开(公告)日：2003-09-11

    申请号：US10379065

    申请日：2003-03-04

    申请人： Sumitomo Eaton Nova Corporation

    发明人： Adam Brailove ,  Hirohiko Murata

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/284

    摘要： A mass separation filter has a first magnet forming a first magnetic field in an orthogonal direction to a beam axis of an ion beam, a second magnet sequentially arranged with the first magnet along the beam axis, parallel with and facing the opposite direction of the first magnet, and forming a second magnetic field orthogonal to the beam axis; and a collimator wall formed within the first and second magnetic fields that forms a transfer channel from a first curved channel deflected from the first magnetic field to a second curved channel deflected by the second magnetic field in a direction the reverse of the first magnetic field. Incident ions pass through a channel inversely curved by the magnetic fields of the first and second magnets according to the mass separation filter, and it is possible to lead ions of a desired mass in the same direction as the beam axis.

    摘要翻译： 质量分离过滤器具有形成与离子束的束轴正交的第一磁场的第一磁体，沿着光束轴线与第一磁体顺序排列的第二磁体，与第一磁体平行并面向第一磁体的相反方向 并形成与光束轴正交的第二磁场; 以及形成在第一和第二磁场内的准直器壁，其形成从第一磁场偏转的第一弯曲通道到由第二磁场偏转的第二弯曲通道在与第一磁场相反的方向上的转移通道。 事件离子通过根据质量分离过滤器由第一和第二磁体的磁场反向弯曲的通道，并且可以将所需质量的离子导引在与光束轴线相同的方向上。

    Detection Method
    28.
    发明申请
    Detection Method 有权
    检测方法

    公开(公告)号：US20030168587A1

    公开(公告)日：2003-09-11

    申请号：US10344186

    申请日：2003-02-07

    发明人： Kurt Tiefenthaler

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/164 ,  G01N21/552 ,  G01N21/7746

    摘要： The described systematics for detecting a substance or substances in a sample or in a matrix of samples, by way of the combination of detection methods on the one hand based on direct detection with integrated optical (bio)chemo-sensitive waveguide grating structures and on the other hand based on a mass-spectrometric detection effected by way of a desorption process, permit an increase of the detection security and/or detection sensitivity.

    摘要翻译： 用于通过基于检测方法的组合来检测样品中或物质矩阵中的物质或物质的所述系统，一方面基于直接检测与集成的光学（生物）化学敏感波导光栅结构，以及在 另一方面，基于通过解吸过程实现的质谱检测，允许提高检测安全性和/或检测灵敏度。

    Cold spray mass spectrometric device
    29.
    发明申请
    Cold spray mass spectrometric device 有权
    冷喷雾质谱仪

    公开(公告)号：US20030168586A1

    公开(公告)日：2003-09-11

    申请号：US10343329

    申请日：2003-02-06

    发明人： Kentaro Yamaguchi ,  Tatsuji Kobayashi

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/0468 ,  B05B5/001 ,  B05B5/0255 ,  H01J49/044 ,  H01J49/165

    摘要： The instrument cold sprays a solution sample at a low temperature and desolvates the sample. Under this condition, a mass analysis is performed. The instrument comprises a needle pipe (8) through which the solution sample is passed, a sheath tube (24) formed coaxially with the needle pipe (8) and passing a temperature-controlled nebulizing gas therethrough, the above-described desolvation block (3), means for cooling the block (15), means for heating the block (4), and a temperature sensor (5) for detecting the temperature of the block (3). The block (3) has a passage for charged liquid droplets of the solution sample cold sprayed from the tip of the needle pipe (8), and acts to remove the solvent from the charged liquid droplets flowing through the passage. A coldspray mass spectrometer is offered which has a desolvation block whose temperature can be easily controlled. In the instrument, condensation of water and electrical leakage are prevented for a long time. The instrument can perform measurements stably and is easy to handle.

    摘要翻译： 仪器冷却在低温下喷射溶液样品并使样品脱水。 在这种条件下，进行质量分析。 该仪器包括通过溶液样品的针管（8），与针管（8）同轴形成并通过温度控制的雾化气体的鞘管（24），上述去溶剂化块（3） ），用于冷却块（15）的装置，用于加热块（4）的装置和用于检测块（3）的温度的温度传感器（5）。 块（3）具有从针管（8）的尖端冷喷射的溶液样品的带电液滴的通道，并且用于从流经通道的带电液滴中除去溶剂。 提供了一种冷喷射质谱仪，其具有一个去溶剂化块，其温度可以容易地控制。 在仪器中，长时间防止水和漏电的结露。 仪器可以稳定地进行测量并且易于处理。

    Proteomic determination of protein nitrotyrosine modifications using mass spectrometry
    30.
    发明申请
    Proteomic determination of protein nitrotyrosine modifications using mass spectrometry 审中-公开
    蛋白质组学测定蛋白质硝基酪氨酸修饰使用质谱法

    公开(公告)号：US20030165983A1

    公开(公告)日：2003-09-04

    申请号：US09847522

    申请日：2001-05-01

    发明人： Bradford W. Gibson ,  Soumitra S. Ghosh ,  Robert E. Davis

    IPC分类号： G01N033/53 ,  H01J049/00

    CPC分类号： G01N33/6812

    摘要： Compositions and methods are provided for identifying oxidative modifications of proteins by mass spectrometric analysis, including MALDI-TOF MS, of protein and peptide fractions of biological samples to determine specific occurrences of nitrotyrosine at amino acid sequence and proteomic levels. Diagnostic methods for diseases characterized by elevated free radicals and oxidative stress, and screening assays for therapeutic agents useful in treating such diseases, are also disclosed.

    摘要翻译： 提供组合物和方法，用于通过质谱分析（包括MALDI-TOF MS）鉴定生物样品的蛋白质和肽级分的蛋白质的氧化修饰，以确定硝酸酪氨酸在氨基酸序列和蛋白质组学水平上的具体发生。 还公开了以自由基升高和氧化应激升高为特征的疾病的诊断方法，以及用于治疗这些疾病的治疗剂的筛选试验。