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公开(公告)号:US20220362004A1
公开(公告)日:2022-11-17
申请号:US17838694
申请日:2022-06-13
Applicant: Biorez, Inc.
Inventor: Kevin A. Rocco , Bhavana Mohanraj , Jeffrey Ott , Justin Bendigo , Jacob Edward Komenda , Mark Theodore Aronson , Andrew James Carter
IPC: A61F2/08 , A61L27/24 , A61L27/52 , A61L27/18 , A61L27/56 , A61F2/00 , A61L27/48 , D06N3/00 , A61L27/14 , A61L27/26 , A61L27/58
Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.
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公开(公告)号:US20220331492A1
公开(公告)日:2022-10-20
申请号:US17741358
申请日:2022-05-10
Applicant: Bard Shannon Limited
Inventor: Guy Tomer , Aurelie Benaddi , Moriah Anouchi , Amir Hadid
IPC: A61L27/52 , A61K9/16 , A61K31/496 , A61K31/7036 , A61L27/22 , A61L27/48 , A61L27/54
Abstract: A composition, comprising a hydrogel matrix and microparticles within said matrix, said matrix comprising a cross-linkable protein and a cross-linking agent, wherein said cross-linking agent is able to cross-link said cross-linkable protein, wherein said microparticles comprise a drug.
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公开(公告)号:US20220280698A1
公开(公告)日:2022-09-08
申请号:US17686928
申请日:2022-03-04
Applicant: Georgia Tech Research Corporation
Inventor: Cameron William Irvin , Meisha Shofner
Abstract: Disclosed herein are hybrid materials including a polyvinyl alcohol component combined with a filler. The filler may be one or more of crystalline nanocellulose and chitin nanofibers. The hybrid materials may also include water, and in such cases are designated hydrogels. The hybrid materials may be substantially free of solvents including water, and in such cases are designated aerogels. The hydrogels, aerogels, and combinations thereof may be advantageously included in biomimetic implants, including as a biomimetic intervertebral disc replacement
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公开(公告)号:US11427665B2
公开(公告)日:2022-08-30
申请号:US16994167
申请日:2020-08-14
Applicant: STAAR Surgical Company
Inventor: Alexei V. Ossipov , Keith Holliday
IPC: A61F2/16 , C08F220/28 , C08L33/14 , A61L27/24 , A61L27/48 , A61L27/50 , G02B1/04 , B29D11/00 , G02C7/02 , A61F2/00
Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.
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公开(公告)号:US11351261B2
公开(公告)日:2022-06-07
申请号:US16025639
申请日:2018-07-02
Applicant: 206 ORTHO, Inc.
Inventor: Jeffrey A. D'Agostino , Robert S. Whitehouse , Andrew J. Carter , Arthur Watterson , Joseph P. Lane , Ian D. McRury , Samantha Marchetti , Nikole Seil
IPC: A61K47/02 , A61L27/48 , A61L27/50 , A61L27/58 , A61B17/72 , A61F2/28 , A61L27/44 , A61B17/70 , A61K47/32 , A61K47/34 , A61B17/00
Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. A method for treating a bone, the method comprising: selecting at least one reinforcing element to be combined with an injectable matrix material so as to together form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity in the bone so that the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a non-flowable state so as to establish a static structure for the composite implant, such that the composite implant supports the adjacent bone.
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公开(公告)号:US20220168089A1
公开(公告)日:2022-06-02
申请号:US17674736
申请日:2022-02-17
Applicant: Biostage, Inc
Inventor: Ron SOSTEK
Abstract: Aspects of this disclosure relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component in a perfusion pathway. In some embodiments, materials (e.g. synthetic materials) for the scaffold are printed, molded, cast, polymerized or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.
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公开(公告)号:US20220168088A1
公开(公告)日:2022-06-02
申请号:US17674711
申请日:2022-02-17
Applicant: Biostage,
Inventor: Ron SOSTEK
Abstract: Aspects of this disclosure relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component in a perfusion pathway. In some embodiments, materials (e.g. synthetic materials) for the scaffold are printed, molded, cast, polymerized or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.
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公开(公告)号:US20220111118A1
公开(公告)日:2022-04-14
申请号:US17338274
申请日:2021-06-03
Applicant: 206 Ortho, Inc.
Inventor: Jeffrey A. D'AGOSTINO , Werner Blank , Elizabeth NELSON , Charles Hegedus , Sandip Agarwal , Robert S. Whitehouse
IPC: A61L27/18 , A61K9/00 , A61K47/34 , A61L27/54 , A61L27/58 , A61L27/16 , A61L27/56 , A61L27/48 , A61L27/46 , A61L27/44 , A61L27/26 , A61L27/52
Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
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公开(公告)号:US11298440B2
公开(公告)日:2022-04-12
申请号:US17236738
申请日:2021-04-21
Applicant: BVW Holding AG
Inventor: Lukas Bluecher , Michael Milbocker
Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
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公开(公告)号:US20220080085A1
公开(公告)日:2022-03-17
申请号:US17485766
申请日:2021-09-27
Applicant: Prosidyan, Inc.
Inventor: Charanpreet S. Bagga , Steve B. Jung , Hyun W. Bae
IPC: A61L27/56 , A61L27/54 , A61L27/30 , A61L27/32 , A61L27/42 , A61L27/10 , C08L71/02 , A61L27/44 , A61L27/12 , A61L27/48 , A61L27/58
Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
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