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    Tissue protein PP.sub.4, a process for isolating it and its use
    26.
    发明授权
    Tissue protein PP.sub.4, a process for isolating it and its use 失效
    组织蛋白PP4，其分离过程及其用途

    公开(公告)号：US4507229A

    公开(公告)日：1985-03-26

    申请号：US603346

    申请日：1984-04-24

    申请人： Hans Bohn

    发明人： Hans Bohn

    IPC分类号： G01N33/53 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  G01N33/531 ,  C07G7/00 ,  A61K35/42 ,  A61K35/50 ,  A61K39/395

    CPC分类号： C07K14/4721 ,  C07K16/18 ,  Y10S530/806 ,  Y10S530/834 ,  Y10S530/835 ,  Y10S530/838 ,  Y10S530/842 ,  Y10S530/844 ,  Y10S530/851

    摘要： The protein PP.sub.4 which has(a) an electrophoretic mobility in the range between that of .alpha..sub.1 and .alpha..sub.2 globulins;(b) an isoelectric point of 4.85.+-.0.15;(c) a sedimentation coefficient s.sub.20,w.sup.0 of 3.3.+-.0.2S;(d) a molecular weight determined in polyacrylamide gel containing sodium dodecylsulfate (DSD) of 35,000.+-.5,000;(e) an extinction coefficient E.sub.1 cm.sup.1% (280 nm) of 5.9.+-.0.6;(f) a carbohydrate content of 2.4.+-.0.94% (g/100 g) (mannose 0.3.+-.0.2%, galactose 0.4.+-.0.2%, xylose 0.1.+-.0.4%, glucose 0.2.+-.0.1%, glucosamine 1.0.+-.0.2% and neuraminic acid 0.4.+-.0.2%) and(g) a specified aminoacid composition, and a process for its preparation are described. PP.sub.4 can be used to prepare antisera which can be employed to detect and determine PP.sub.4 in body fluids in order to diagnose diseases of particular organs, as a "marker" to monitor the progress of a disease or to check therapy.

    摘要翻译： 蛋白质PP4，其具有（a）在α1和α2球蛋白之间的范围内的电泳迁移率; （b）等电点4.85 +/- 0.15; （c）沉降系数s20，w0为3.3±0.2S; （d）在含有35,000 +/- 5,000的十二烷基硫酸钠（DSD）的聚丙烯酰胺凝胶中测定的分子量; （e）消光系数E1cm1％（280nm）为5.9 +/- 0.6; （f）碳水化合物含量为2.4±0.94％（g / 100g）（甘露糖0.3±0.2％，半乳糖0.4±0.2％，木糖0.1±0.4％，葡萄糖0.2±0.1 ％，葡糖胺1.0 +/- 0.2％，神经氨酸0.4±0.2％）和（g）指定的氨基酸组合物及其制备方法。 PP4可用于制备抗血清，可用于检测和测定体液中的PP4，以诊断特定器官的疾病，作为监测疾病进展或检查治疗的“标志物”。

    Salts of amino-acids with polysulfuric esters of natural gly-copeptides and process for preparing same
    27.
    发明授权
    Salts of amino-acids with polysulfuric esters of natural gly-copeptides and process for preparing same 失效
    氨基酸的盐与天然甘油三肽的多硫酸酯及其制备方法

    公开(公告)号：US3872075A

    公开(公告)日：1975-03-18

    申请号：US40517973

    申请日：1973-10-10

    申请人： CRINOS INDUSTRIA FARMACO

    发明人： BUTTI ADRIANO ,  PRINO GIUSEPPE

    IPC分类号： A61K35/38 ,  A61K38/00 ,  C07K9/00 ,  C07G7/00

    CPC分类号： C07K9/00 ,  A61K38/02 ,  Y10S530/843 ,  Y10S530/844

    摘要： A process for obtaining salts of amino-acids with polysulfuric esters of glycopeptides comprises reacting an aqueous solution of a sulfoglycopeptide in the acid form with a slight excess of one or more free amino-acids, dialysing the solution of the obtained salt and finally separating the product by dilution and precipitation with selective solvents or by concentration under reduced pressure followed by a lyophilization process. The thus obtained salts of natural or synthetic amino-acids with sulfoglycopeptides possess a remarkable anti-inflammatory pharmacological action useful for treating gastro-duodenal ulcerous phenomena without dangerous side effects.

    摘要翻译： 用糖肽的多硫酸酯获得氨基酸的盐的方法包括使酸形式的磺基多肽的水溶液与稍微过量的一种或多种游离氨基酸反应，透析所得盐的溶液，最后分离 产物通过稀释并用选择性溶剂沉淀或通过减压浓缩，接着进行冻干处理。 由此获得的天然或合成氨基酸与磺基多肽的盐具有显着的抗炎药理学作用，可用于治疗胃十二指肠溃疡现象而没有危险的副作用。

    Protein-sulfonyl halide complex ruminant feed material
    28.
    发明授权
    Protein-sulfonyl halide complex ruminant feed material 失效
    蛋白磺酰卤化合物反应物进料

    公开(公告)号：US3711289A

    公开(公告)日：1973-01-16

    申请号：US3711289D

    申请日：1970-10-27

    申请人： MONSANTO CO

    发明人： MILLER R

    IPC分类号： A23K1/16 ,  A23K1/00

    CPC分类号： A23K20/147 ,  Y10S530/844

    摘要： IMPROVED PROTEIN FEED MATERIAL FOR RUMINANTS WHICH IS RESISTANT TO DIGESTIVE BREAKDOWN IN THE RUMEN BUT NOT IN THE ABOSMASUM AND/OR INTESTINES WHICH COMPRISES THE REACTION PRODUCT OF A PROTEIN-CONTAINING FEED MATERIAL AND AN ALKYL OR ARYL SULFONYL HALIDE. EXEMPLARY OF SUCH SULFONYL HALIDES IS P-TOLYL SULFONYL CHLORIDE.

    Method of purifying intrinsic factor
    30.
    发明授权
    Method of purifying intrinsic factor 失效
    净化内在因素的方法

    公开(公告)号：US3591678A

    公开(公告)日：1971-07-06

    申请号：US3591678D

    申请日：1969-09-05

    申请人： AMERICAN CYANAMID CO

    发明人： ELLENBOGEN LEON ,  HIGHLEY DEREK ROWLAND

    IPC分类号： A61K35/38 ,  A61K27/00

    CPC分类号： A61K35/38 ,  Y10S530/836 ,  Y10S530/843 ,  Y10S530/844

    摘要： A PROCESS FOR PURIFYING INTRINSIC FACTOR BY A BATCH CHROMATOGRAPHY PROCESS WHICH UTILIZES AN ION EXCHANGE RESIN; AND THE RESULTANT HIGH PURITY INTRINSIC FACTOR. TYPICALLY, IMPURE INTRINSIC FACTOR IS DISSOLVED IN A BUFFER SOLUTION HAVING RELATIVELY LOW PH AND IONIC STRENGTH, AND THE RESULTANT SOLUTION IS CONTACTED WITH A CELLULOSIC EXCHANGE RESIN. THE RESIN IS SEPARATED FROM THE SOLUTION AND THE PURIFIED INTRINSIC FACTOR IS ELUTED THEREFROM WITH A BUFFER SOLUTION HAVING A HIGHER PH AND IONIC STRENGTH THAN THE BUFFER SOLUTION IN WHICH THE IMPURE INTRINSIC FACTOR WAS DISSOLVED. THE PRODUCT IS RECOVERED FROM THE ELUATE BY EVAPORATING THE LIQUID SOLVENT. THE RESIDUE, WHICH IS THE PURIFIED PRODUCT, HAS A POTENCY OF AT LEAST 1 N.F. UNIT IN AMOUNTS AS LOW AS 0.5 MG.