公开(公告)号：US07718440B2

公开(公告)日：2010-05-18

申请号：US11749073

申请日：2007-05-15

Applicant: Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

Inventor： Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

IPC: G01N21/72

CPC classification number: G01N21/7743 ,  B01L3/5085 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/1804 ,  G01J3/42 ,  G01N21/253 ,  G01N21/31 ,  G01N33/54373 ,  G01N2021/3196 ,  G01N2021/7773 ,  G02B5/1809 ,  Y10S436/805

Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.

Abstract translation: 对生物传感器的光谱特性进行相对偏移的高分辨率测定。 生物传感器的共振峰的偏移指示与生物传感器的表面结合的材料的量。 优选的生物传感器是引导模式谐振滤波器生物传感器（GMRFB）。 在本发明的一个方面，使用曲线拟合来确定未暴露的生物传感器的光谱相对于通过存在与生物传感器的表面结合的材料而被改变（例如，偏移）的那些光谱的相对位置。 在替代实施例中，互相关函数用于检测参考光谱和从暴露的生物传感器测量的光谱之间的光谱峰值偏移。 在另一替代方案中，使用最大似然估计技术来确定频谱偏移或偏移。

公开(公告)号：US20100068740A1

公开(公告)日：2010-03-18

申请号：US12513416

申请日：2007-11-05

Applicant: David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

Inventor： David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

IPC: C12M1/34 ,  B29C39/02 ,  C12Q1/02 ,  C12Q1/28 ,  C12Q1/54 ,  C12Q1/34

CPC classification number: B29D11/0074 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/163 ,  B29C39/02 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/06 ,  G01J3/10 ,  G01J3/1804 ,  G01J3/42 ,  G01N33/54386 ,  G01N2021/0346

Abstract: A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.

Abstract translation: 制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体， 并提取细长杆以在凝固体中形成圆柱形微通道。 在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。 还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。 提供额外的微流体装置，其用作光流体光谱仪。 光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。

公开(公告)号：US07649627B2

公开(公告)日：2010-01-19

申请号：US11703643

申请日：2007-02-08

Applicant: Toshikazu Yamamoto

Inventor： Toshikazu Yamamoto

IPC: G01J3/26

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0297 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J2003/2873 ,  G01N21/274

Abstract: In a wavelength calibration method, an observed spectrum of a light that has a wavelength band is obtained, wherein the light has at least an attenuated wavelength component that corresponds to at least a predetermined absorption wavelength that is included in the wavelength band. A corrected spectrum is then obtained from the observed spectrum, wherein the corrected spectrum has reduced dependencies upon the full width at half maximum of an emission band of the light and upon an intensity ripple period of the light.

Abstract translation: 在波长校准方法中，获得具有波长带的光的观察光谱，其中光至少具有对应于包括在波长带中的至少预定吸收波长的衰减波长分量。 然后从观察到的光谱获得校正的光谱，其中校正光谱对光的发射带的半峰全宽和光强度波动周期的依赖性降低。

公开(公告)号：US20090317935A1

公开(公告)日：2009-12-24

申请号：US12489636

申请日：2009-06-23

Applicant: Atsushi Toda ,  Hirofumi Sumi

Inventor： Atsushi Toda ,  Hirofumi Sumi

IPC: H01L31/18

CPC classification number: G01J3/2823 ,  G01J3/04 ,  G01J3/1804 ,  G01J3/2803 ,  G01J3/502 ,  G01J3/51 ,  G01J3/513 ,  H01L27/14623 ,  H01L27/14625 ,  H01L27/14645 ,  H01L27/14687 ,  H01L27/14689 ,  H01L27/14831 ,  H04N5/2254 ,  H04N9/045 ,  H04N9/07

Abstract: A method for manufacturing a semiconductor device for detecting a physical amount distribution, the semiconductor device comprising unit components arrayed in a predetermined order, the unit components each including a unit signal generation portion for detecting an electromagnetic wave and outputting the corresponding unit signal. A diffraction grating is provided on the incident light side of a spectral image sensor, the diffraction grating including scatterers, slits, and scatterers disposed in that order. An electromagnetic wave is scattered by the scatterers to produce diffracted waves, and by using the fact that interference patterns between the diffracted waves change with wavelengths, signals are detected for respective wavelengths by photoelectric conversion elements in each photodiode group.

Abstract translation: 一种用于制造用于检测物理量分布的半导体器件的方法，所述半导体器件包括以预定顺序排列的单元组件，所述单元组件各自包括用于检测电磁波的单元信号生成部分并输出相应的单位信号。 衍射光栅设置在光谱图像传感器的入射光侧，衍射光栅包括依次布置的散射体，狭缝和散射体。 电磁波被散射体散射以产生衍射波，并且通过使用衍射波之间的干涉图案随波长变化的事实，通过每个光电二极管组中的光电转换元件检测各波长的信号。

公开(公告)号：US20090310135A1

公开(公告)日：2009-12-17

申请号：US12374247

申请日：2007-07-20

Applicant: Ronny Bockstaele ,  Bert Luyssaert ,  Kris Naessens

Inventor： Ronny Bockstaele ,  Bert Luyssaert ,  Kris Naessens

IPC: G01J3/28 ,  G02B5/18 ,  G02B27/30

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0294 ,  G01J3/18

Abstract: An optical characterisation system is described for characterising optical material. The system typically comprises a diffractive element (104), a detector (106) and an optical element (102). The optical element (102) thereby typically is adapted for receiving an illumination beam, which may be an illumination response of the material. The optical element (102) typically has a refractive surface for refractively collimating the illumination beam on the diffractive element (104) and a reflective surface for reflecting the diffracted illumination beam on the detector (106). The optical element (102) furthermore is adapted for cooperating with the diffractive element (104) and the detector (106) being positioned at a same side of the optical element (102) opposite to the receiving side for receiving the illumination beam.

Abstract translation: 描述了用于表征光学材料的光学表征系统。 该系统通常包括衍射元件（104），检测器（106）和光学元件（102）。 因此，光学元件（102）通常适于接收可以是材料的照明响应的照明光束。 光学元件（102）通常具有用于折射地准直衍射元件（104）上的照明光束的折射表面和用于将衍射照射光束反射在检测器（106）上的反射表面。 光学元件（102）还适于与衍射元件（104）和检测器（106）配合，所述衍射元件（104）位于与用于接收照明光束的接收侧相对的光学元件（102）的同一侧。

公开(公告)号：US20090273840A1

公开(公告)日：2009-11-05

申请号：US12432829

申请日：2009-04-30

Applicant: Sheldon MCLAUGHLIN

Inventor： Sheldon MCLAUGHLIN

IPC: G02B5/18

CPC classification number: G02B6/29313 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/1804 ,  G01J3/22 ,  G02B5/12 ,  G02B5/1809 ,  G02B5/1814 ,  G02B5/1866 ,  G02B6/2931 ,  G02B6/29311 ,  G02B6/2938 ,  G02B6/354 ,  G02B17/0856 ,  G02B2005/1804

Abstract: A compact wavelength dispersing device and a wavelength selective optical switch based on the wavelength dispersing device is described. The wavelength dispersing device has a folding mirror that folds the optical path at least three times. A focal length of a focusing coupler of the device is reduced and the NA is increased, while the increased optical aberrations are mitigated by using an optional coma-compensating wedge. A double-pass arrangement for a transmission diffraction grating allows further focal length and overall size reduction due to increased angular dispersion.

Abstract translation: 描述了基于波长分散装置的紧凑型波长分散装置和波长选择光开关。 波长分散装置具有将光路折叠至少三次的折叠镜。 减少了设备的聚焦耦合器的焦距，并且增加了NA，同时通过使用可选的光阑补偿楔来减轻增加的光学像差。 用于透射衍射光栅的双通道布置允许由于增加的角度分散而使焦距和总体尺寸减小。

公开(公告)号：US20080291445A1

公开(公告)日：2008-11-27

申请号：US12078697

申请日：2008-04-03

Applicant: Toru Iwane

Inventor： Toru Iwane

IPC: G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262

Abstract: The spectroscopic instrument includes a plurality of first lenses arranged one-dimensionally or two-dimensionally; an aperture opening provided near a focal plane of each of the plurality of first lenses; a spectroscopic unit that spectrally distribute the light that has passed through the aperture opening; and a light receiving unit that receives the light spectrally distributed by the spectroscopic unit. The image producing device includes: the spectroscopic instrument; an imaging unit that captures an image formed by an imaging optical system; and an image processing unit that acquires a lighting condition from a result of spectroscopy by the spectroscopic instrument and performs color conversion processing depending on the lighting condition on an image captured by the imaging unit.

Abstract translation: 光谱仪包括一维或二维排列的多个第一透镜; 设置在所述多个第一透镜中的每一个的焦平面附近的孔径开口; 分光单元，其光谱地分布已经穿过所述孔口的光; 以及光接收单元，其接收由分光单元光谱分布的光。 图像产生装置包括：光谱仪; 成像单元，其捕获由成像光学系统形成的图像; 以及图像处理单元，其根据所述分光仪器的光谱结果获取照明条件，并根据所述成像单元拍摄的图像上的照明条件进行颜色转换处理。

公开(公告)号：US07426040B2

公开(公告)日：2008-09-16

申请号：US11206900

申请日：2005-08-19

Applicant: Hong Koo Kim ,  Zhijun Sun ,  Yun Suk Jung

Inventor： Hong Koo Kim ,  Zhijun Sun ,  Yun Suk Jung

IPC: G01B9/02

CPC classification number: G02B6/1225 ,  B82Y20/00 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0259 ,  G01J3/1804 ,  G01J3/26 ,  G01J3/2803 ,  G01J3/2823 ,  G01J4/04 ,  G01J2003/1213 ,  G01N21/6452 ,  G01N2021/6439 ,  G02B5/1857 ,  G02B5/284 ,  Y10S977/932

Abstract: A Fabry-Perot cavity filter includes a first mirror and a second mirror. A gap between the first and the second mirror monotonically varies as a function of width of the filter. This filter may be used with photodetector and a channel selection filter in an optical device, such as a spectrum analyzer. The channel selection filter may be a metal nanooptic filter array which includes plurality of subwavelength apertures in a metal film or between metal islands.

Abstract translation: 法布里 - 珀罗腔滤波器包括第一反射镜和第二反射镜。 第一和第二镜之间的间隙根据滤光片的宽度而单调变化。 该滤光器可以与诸如光谱分析仪的光学装置中的光电检测器和通道选择滤光器一起使用。 通道选择滤光器可以是金属纳滤光器阵列，其包括在金属膜中或金属岛之间的多个亚波长孔。

公开(公告)号：US20080218752A1

公开(公告)日：2008-09-11

申请号：US11925076

申请日：2007-10-26

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/30

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/06 ,  G01J3/1804 ,  G01J3/2846 ,  G01J3/42 ,  G01J2001/4242 ,  G01J2003/1217

Abstract: A chemometric analyzer for analyzing a plurality of analytes. The analyzer disperses radiation by wavelength along an encoding axis. The analyzer includes a spatial radiation modulator having a plurality of radiation filters. Each radiation filter modulates the intensity of a corresponding spectral component in the radiation.

Abstract translation: 用于分析多种分析物的化学计量分析仪。 分析仪沿着编码轴沿波长分散辐射。 分析仪包括具有多个辐射过滤器的空间辐射调制器。 每个辐射滤波器调制辐射中对应的光谱分量的强度。

公开(公告)号：US20080043314A1

公开(公告)日：2008-02-21

申请号：US11925115

申请日：2007-10-26

Applicant: Thomas Hagler

Inventor： Thomas Hagler

IPC: G02F1/00

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/06 ,  G01J3/1804 ,  G01J3/2846 ,  G01J3/42 ,  G01J2001/4242 ,  G01J2003/1217

Abstract: A two dimensional spatial radiation modulator rotated about a rotation axis to modulate components of an incident radiation beam to encode the beam. The modulator includes sub-regions in a first annular segment being patterned to form a pair of radiation filters having substantially complementary modulation functions. The pair of radiation filters produces a first encoded component with a characteristic determined by the relative intensities of radiation from the beam incident on the pair of filters. The modulator also includes sub-regions in a second annular segment being patterned to form a filter that produces a second encoded component with a characteristic determined by the total intensity of radiation from the beam incident on the filter.

Abstract translation: 围绕旋转轴旋转的二维空间辐射调制器，以调制入射辐射束的分量以编码光束。 调制器包括在第一环形区段中的子区域被图案化以形成具有实质上互补的调制功能的一对辐射滤波器。 该对辐射滤波器产生具有由入射在该对滤波器上的光束的辐射的相对强度确定的特性的第一编码分量。 调制器还包括被构图的第二环形区段中的子区域，以形成滤波器，该滤波器产生具有由入射在滤波器上的光束的总辐射强度确定的特性的第二编码分量。