公开(公告)号：US5891727A

公开(公告)日：1999-04-06

申请号：US849553

申请日：1992-03-11

申请人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： John P. Dirlam ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： A23K20/195 ,  C07H17/04 ,  C12P17/16 ,  C12P19/60 ,  C12N1/00

CPC分类号： C12P17/162 ,  A23K20/195 ,  C07H17/04 ,  C12P19/60 ,  Y10S435/825

摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.

摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53676.这种新型抗生素在小鸡和牛和猪的生长促进剂中作为抗球虫病有用。

公开(公告)号：US5484712A

公开(公告)日：1996-01-16

申请号：US369375

申请日：1995-01-06

申请人： Won T. Cho ,  Wan S. Kim ,  Myung K. Kim ,  Jin K. Park ,  Hak R. Kim ,  Sang K. Rhee ,  A. G. Domracheva ,  T. B. Panichkina ,  L. A. Saburoba ,  L. M. Nobikoba ,  Y. E. Bartochevichi

发明人： Won T. Cho ,  Wan S. Kim ,  Myung K. Kim ,  Jin K. Park ,  Hak R. Kim ,  Sang K. Rhee ,  A. G. Domracheva ,  T. B. Panichkina ,  L. A. Saburoba ,  L. M. Nobikoba ,  Y. E. Bartochevichi

IPC分类号： A61K31/65 ,  A61K31/655 ,  A61P35/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/09 ,  C12P15/00 ,  C12P19/56 ,  C12P19/58 ,  C12P19/60 ,  C12R1/465 ,  C07H17/04 ,  C07H15/244

CPC分类号： C12R1/56 ,  C12P15/00 ,  C12P19/56 ,  C12P19/60 ,  Y10S435/886

摘要： Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS(KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.

摘要翻译： 本文公开了一种新型链霉菌菌株，以及通过培养它们来生产阿克拉霉素A，B，Y及其糖苷配基的方法。 本发明的枸杞子链霉菌DKRS（KCTC 0092BP）能够以更高的产率生产阿奇霉素A，B，Y和糖苷配基。 此外，可以通过将醋酸链霉菌DKRS的培养肉汤的pH分别用醋酸盐缓冲液或盐酸调节至4.4或4.6来选择性地产生阿克拉霉素A或Y。

公开(公告)号：US5468637A

公开(公告)日：1995-11-21

申请号：US192165

申请日：1994-02-04

申请人： Won T. Cho ,  Wan S. Kim ,  Myung K. Kim ,  Jin K. Park ,  Hak R. Kim ,  Sang K. Rhee ,  A. G. Domracheva ,  T. B. Panichkina ,  L. A. Saburoba ,  L. M. Nobikoba ,  Y. E. Bartochevichi

发明人： Won T. Cho ,  Wan S. Kim ,  Myung K. Kim ,  Jin K. Park ,  Hak R. Kim ,  Sang K. Rhee ,  A. G. Domracheva ,  T. B. Panichkina ,  L. A. Saburoba ,  L. M. Nobikoba ,  Y. E. Bartochevichi

IPC分类号： A61K31/65 ,  A61K31/655 ,  A61P35/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/09 ,  C12P15/00 ,  C12P19/56 ,  C12P19/58 ,  C12P19/60 ,  C12R1/465 ,  C07H17/04 ,  C07H15/244

CPC分类号： C12R1/56 ,  C12P15/00 ,  C12P19/56 ,  C12P19/60 ,  Y10S435/886

摘要： Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.

摘要翻译： 本文公开了一种新型链霉菌菌株，以及通过培养它们来生产阿克拉霉素A，B，Y及其糖苷配基的方法。 本发明的枸杞子链霉菌DKRS（KCTC 0092BP）能够以更高的产率生产阿奇霉素A，B，Y和糖苷配基。 此外，可以通过将醋酸链霉菌DKRS的培养肉汤的pH分别用醋酸盐缓冲液或盐酸调节至4.4或4.6来选择性地产生阿克拉霉素A或Y。

公开(公告)号：US5432161A

公开(公告)日：1995-07-11

申请号：US501900

申请日：1990-03-30

申请人： Shuzo Sakai ,  Masaru Yoneyama ,  Toshio Miyake

发明人： Shuzo Sakai ,  Masaru Yoneyama ,  Toshio Miyake

IPC分类号： C12P19/58 ,  A23L33/15 ,  A61K8/67 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7042 ,  A61K31/7048 ,  A61P3/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07D307/62 ,  C07H15/26 ,  C07H17/04 ,  C12P19/16 ,  C12P19/18 ,  C12P19/60 ,  C07H1/00

CPC分类号： C12P19/60 ,  A61K31/7004 ,  A61K31/7024 ,  A61K8/67 ,  A61K8/676 ,  A61Q19/00 ,  A61Q19/02 ,  C07H17/04 ,  C12P19/16 ,  C12P19/18 ,  C12P19/58 ,  A61Q17/04 ,  A61Q19/10 ,  Y10S435/814 ,  Y10S435/815 ,  Y10S435/816 ,  Y10S435/913 ,  Y10S435/939 ,  Y10S514/844 ,  Y10S514/846

摘要： 2-O-.alpha.-D-Glucopyranosyl-L-ascrobic acid is crystallizable in its supersaturated solution. Crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is substantially nonhygroscopic, free flowing, free of deliquescence, consolidation and direct reducing activity, but is readily soluble in water. Because of these characteristics, crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is handleable with an ease, and superiorly high in stability and physiological activities. Thus, crystalline 2-O-.alpha.-D-glucopyranosyl-L-acorbic acid is favorably useful in vitamin C-enriching agents, foodstuffs, pharmaceuticals and cosmetics.

摘要翻译： 2-O-α-D-吡喃葡萄糖基-L-降血糖在其过饱和溶液中可结晶。 结晶的2-O-α-D-吡喃葡萄糖基-L-抗坏血酸是基本上不吸湿的，自由流动的，没有潮解，固化和直接还原活性，但易溶于水。 由于这些特性，结晶2-O-α-D-吡喃葡萄糖基-L-抗坏血酸易于处理，并且具有优异的稳定性和生理活性。 因此，结晶的2-O-α-D-吡喃葡萄糖基-L-抗坏血酸有利地用于维生素C富集剂，食品，药物和化妆品。

公开(公告)号：US5252722A

公开(公告)日：1993-10-12

申请号：US964037

申请日：1992-10-21

申请人： Takahiko Mandai ,  Masaru Yoneyama ,  Shuzo Sakai

发明人： Takahiko Mandai ,  Masaru Yoneyama ,  Shuzo Sakai

IPC分类号： A23L33/15 ,  A61K8/00 ,  A61K8/60 ,  A61K8/67 ,  A61K31/70 ,  A61K31/7028 ,  A61P3/02 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07H15/26 ,  C12P19/58 ,  C12P19/60 ,  C07H15/00 ,  C07D307/62

CPC分类号： C07H15/26 ,  C12P19/60

摘要： 5-O-.alpha.-D-Glucopyranosyl-L-ascorbic acid is a novel derivative of L-ascorbic acid which has a direct reducing activity and a satisfiable stability, as well as being readily hydrolyzed in vivo to form L-ascorbic acid. The 5-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is prepared by allowing a saccharide-transferring enzyme together with or without .alpha.-glucosidase to a solution containing an .alpha.-glucosyl saccharide and L-ascorbic acid, and suitably used in food products, agents of anti-susceptive diseases and cosmetics containing thereof.

摘要翻译： 5-O-α-D-吡喃葡萄糖基-L-抗坏血酸是L-抗坏血酸的新型衍生物，其具有直接还原活性和令人满意的稳定性，并且在体内易于水解以形成L-抗坏血酸。 5-α-D-吡喃葡萄糖基-L-抗坏血酸是通过将糖转移酶与α-葡糖苷酶一起使用或不含α-葡糖基糖和L-抗坏血酸的溶液来制备的，并且适用于 食品，抗感染性药剂和含有它们的化妆品。

公开(公告)号：US5192671A

公开(公告)日：1993-03-09

申请号：US721744

申请日：1991-06-26

申请人： Byron H. Arison ,  Marvin D. Schulman ,  Patrick J. Doherty

发明人： Byron H. Arison ,  Marvin D. Schulman ,  Patrick J. Doherty

IPC分类号： A01N63/00 ,  A01N43/90 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P33/00 ,  A61P33/02 ,  C07H17/08 ,  C07H19/01 ,  C12P19/60 ,  C12P19/62 ,  C12R1/01 ,  C12R1/645

CPC分类号： A61K31/70 ,  A01N43/90 ,  C07H19/01 ,  C12P19/60

摘要： Avermectin compounds are glycosylated the 4' and 4"-positions by adding the avermectin compounds to the fermentation medium of Saccharapolyspora erythrea. The outer oleandrose sugar group of the avermectin compound is glycosylated with a glycosyl moiety, specifically a glucose group. In addition, other changes are effected in the avermectin moiety such as selective hydroxylation, epimerization at the 2-carbon and migration of the .DELTA. 3-double bond to a .DELTA. 2-position.

公开(公告)号：US4996305A

公开(公告)日：1991-02-26

申请号：US161625

申请日：1988-02-29

申请人： William J. McGahren ,  George A. Ellestad

发明人： William J. McGahren ,  George A. Ellestad

IPC分类号： C07H17/00 ,  C12P1/06 ,  C12P19/60 ,  C12P19/64

CPC分类号： C12R1/29 ,  C07H17/00 ,  C12P1/06 ,  C12P19/60 ,  C12P19/64

摘要： Processes for producing antibacterial and antitumor agents designated LL-E33288.epsilon.I and LL-E33288.epsilon.-Br using triphenylphosphine or a sulfhydryl-containing reagent are disclosed. Processes for producing reductively aromatized derivatives of other antibiotics are also disclosed.

摘要翻译： 公开了使用三苯基膦或含巯基试剂制备称为LL-E33288εI和LL-E33288ε-Br的抗细菌剂和抗肿瘤剂的方法。 还公开了生产其它抗生素还原性芳构化衍生物的方法。

公开(公告)号：US4992423A

公开(公告)日：1991-02-12

申请号：US153187

申请日：1988-02-08

申请人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

发明人： Walter P. Cullen ,  Hiroshi Maeda ,  John C. Ruddock ,  Junsuke Tone

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  A61P33/02 ,  C07H17/04 ,  C07H19/01 ,  C12P17/18 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03

CPC分类号： C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization is swine and ruminants. Two minor components, where R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.

公开(公告)号：US4970198A

公开(公告)日：1990-11-13

申请号：US9321

申请日：1987-01-30

申请人： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

发明人： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

IPC分类号： C07H15/203 ,  C12P1/06 ,  C12P19/60

CPC分类号： C07H15/203 ,  C12P1/06 ,  C12P19/60 ,  C12R1/29 ,  Y10S435/867

摘要： Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.

摘要翻译： 名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属 calichensis NNRL-15839，NRRL-15975和NRRL-18149。

公开(公告)号：US4939244A

公开(公告)日：1990-07-03

申请号：US004153

申请日：1987-01-30

申请人： May D.-M. Lee

发明人： May D.-M. Lee

IPC分类号： C07H15/203 ,  C12P19/60

CPC分类号： C07H15/203 ,  C12P19/60 ,  C12R1/29

摘要： Degradation products, termed pseudaglycones, of LL-E33288, BBM-1675, FR-900405, FR-900406, PD 114759, PD 115028, CL-1577A, CL-1577B, CL-1577D, CL-1577E and CL-1724 antibiotics/antitumor agents are disclosed anad described.

摘要翻译： LL-E33288，BBM-1675，FR-900405，FR-900406，PD 114759，PD 115028，CL-1577A，CL-1577B，CL-1577D，CL-1577E和CL-1724抗生素/降解产物，称为假赤藓酮酸， 公开了抗肿瘤药物。