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47 条记录 (耗时 0.021 秒)

    In vitro production of haploid germ cells
    22.
    发明授权
    In vitro production of haploid germ cells 失效
    体外生产单倍体生殖细胞

    公开(公告)号：US06872569B2

    公开(公告)日：2005-03-29

    申请号：US10147576

    申请日：2002-05-16

    申请人： Dong Ryul Lee ,  Michael T. Kaproth ,  John E. Parks

    发明人： Dong Ryul Lee ,  Michael T. Kaproth ,  John E. Parks

    IPC分类号： C12N5/071 ,  C12N5/076 ,  C12N5/06 ,  A01N1/02 ,  C12N5/08

    CPC分类号： C12N5/061 ,  C12N5/0697 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/31 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2502/04 ,  C12N2502/246 ,  C12N2509/00

    摘要： The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method described above, where the spermatids are haploid. The present invention also involves a method of overcoming male infertility in mammals involving the use of the haploid round spermatids produced by the in vitro spermatogenesis method of the present invention. The present invention also relates to isolated haploid spermatids.

    摘要翻译： 本发明涉及一种体外精子发生的方法，其涉及来自雄性哺乳动物的睾丸的Sertoli细胞和二倍体生殖细胞产生分化的单倍体精子细胞。 本发明还涉及通过上述方法制备的精子细胞，其中精子细胞是单倍体。 本发明还涉及克服哺乳动物中的男性不育症的方法，涉及使用通过本发明的体外精子发生方法产生的单倍体圆形精子细胞。 本发明还涉及分离的单倍体精子细胞。

    Prostate cancer cell lines
    25.
    发明授权
    Prostate cancer cell lines 失效
    前列腺癌细胞系

    公开(公告)号：US07238524B2

    公开(公告)日：2007-07-03

    申请号：US10862256

    申请日：2004-06-07

    申请人： Ming Fong Lin

    发明人： Ming Fong Lin

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0683 ,  C12N5/0693 ,  C12N2502/246 ,  C12N2503/00 ,  G01N33/57434

    摘要： Novel human prostate cancer-associated neuroendocrine (NE)-like cell lines are provided that were derived via a process that resembles clinical androgen ablation therapy for advanced prostate cancer.

    摘要翻译： 提供了新的人前列腺癌相关神经内分泌（NE）样细胞系，其通过类似于晚期前列腺癌的临床雄激素消除治疗的过程得到。

    Methods of inducing differentiation of stem cells into a specific cell lineage
    27.
    发明申请
    Methods of inducing differentiation of stem cells into a specific cell lineage 审中-公开
    诱导干细胞分化为特异性细胞谱系的方法

    公开(公告)号：US20050239201A1

    公开(公告)日：2005-10-27

    申请号：US10507765

    申请日：2003-03-14

    申请人： Richard Mollard ,  Alan Trounson ,  Mark Denham

    发明人： Richard Mollard ,  Alan Trounson ,  Mark Denham

    IPC分类号： C12N15/09 ,  A61K35/12 ,  A61L27/00 ,  A61P1/18 ,  A61P11/00 ,  A61P31/12 ,  C12N5/02 ,  C12N5/071 ,  C12N5/0735 ,  C12N5/10 ,  C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0683 ,  A61K35/12 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2502/246 ,  C12N2503/02 ,  C12N2506/02

    摘要： The present invention relates to methods of inducing differentiation of stem cells into a specific cell lineage, preferably lung cells. In particular, the invention relates to in vitro methods of inducing differentiation of stem cells into a specific cell lineage. The invention also relates to methods of producing and recovering differentiated stem cells of a specific cell lineage. The invention also includes differentiated stem cells and cell lineages produced by the methods of the present invention. In one aspect of the present invention there is provided a method of inducing differentiation of a stem cell into a specific cell lineage, preferably lung cells, the method including: culturing a stem cell in vitro in the presence of a tissue sample and/or extracellular medium of a tissue sample, under conditions that induce differentiation of the stem cell into a specific cell lineage, wherein the differentiated stem cell is the same cell type as the tissue sample.

    摘要翻译： 本发明涉及诱导干细胞分化成特定细胞系，优选肺细胞的方法。 特别地，本发明涉及诱导干细胞分化成特定细胞系的体外方法。 本发明还涉及产生和回收特异性细胞谱系的分化干细胞的方法。 本发明还包括通过本发明的方法产生的分化干细胞和细胞谱系。 在本发明的一个方面，提供了诱导干细胞分化为特定细胞系，优选肺细胞的方法，所述方法包括：在组织样品和/或细胞外存在下体外培养干细胞 在诱导干细胞分化成特定细胞谱系的条件下，组织样品的培养基，其中分化的干细胞是与组织样品相同的细胞类型。

    Sertoli cells as biochambers
    29.
    发明授权
    Sertoli cells as biochambers 失效
    Sertoli细胞作为生物体

    公开(公告)号：US06790441B1

    公开(公告)日：2004-09-14

    申请号：US09593629

    申请日：2000-06-13

    申请人： Don F. Cameron ,  Paul R. Sanberg ,  Samuel Saporta ,  Joelle J. Hushen

    发明人： Don F. Cameron ,  Paul R. Sanberg ,  Samuel Saporta ,  Joelle J. Hushen

    IPC分类号： A01N6500

    CPC分类号： C12N5/0677 ,  A61K35/12 ,  C12N5/0619 ,  C12N2502/246

    摘要： According to the present invention, there is provided a biological chamber system having a biochamber defined by outer walls of Sertoli cells. Also provided is a transplantation facilitator including a biochamber. A method of making biochambers by co-culturing facilitator cells and therapeutic cells and then aggregating the facilitator celes is also provided. Also provided is a method of transplanting cells by incorporating transplant cells into a biochamber and transplanting the biochamber containing the transplant cells.

    摘要翻译： 根据本发明，提供了一种具有由Sertoli细胞的外壁限定的生物室的生物室系统。 还提供了包括生物室的移植促进剂。 还提供了通过共培养促进细胞和治疗细胞然后聚集辅助细胞来制备生物体的方法。 还提供了通过将移植细胞并入生物室并移植含有移植细胞的生物室来移植细胞的方法。

    In vitro production of haploid germ cells
    30.
    发明申请
    In vitro production of haploid germ cells 失效
    体外生产单倍体生殖细胞

    公开(公告)号：US20030027329A1

    公开(公告)日：2003-02-06

    申请号：US10147576

    申请日：2002-05-16

    发明人： Dong Ryul Lee ,  Michael T. Kaproth ,  John E. Parks

    IPC分类号： C12N005/06

    CPC分类号： C12N5/061 ,  C12N5/0697 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/31 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2502/04 ,  C12N2502/246 ,  C12N2509/00

    摘要： The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The present invention also relates to spermatids produced by the method described above, where the spermatids are haploid. The present invention also involves a method of overcoming male infertility in mammals involving the use of the haploid round spermatids produced by the in vitro spermatogenesis method of the present invention. The present invention also relates to isolated haploid spermatids.

    摘要翻译： 本发明涉及一种体外精子发生的方法，其涉及来自雄性哺乳动物的睾丸的Sertoli细胞和二倍体生殖细胞产生分化的单倍体精子细胞。 本发明还涉及通过上述方法制备的精子细胞，其中精子细胞是单倍体。 本发明还涉及克服哺乳动物中的男性不育症的方法，涉及使用通过本发明的体外精子发生方法产生的单倍体圆形精子细胞。 本发明还涉及分离的单倍体精子细胞。