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公开(公告)号：US20210236674A1
公开(公告)日：2021-08-05
申请号：US16972025
申请日：2019-06-07
IPC分类号： A61L2/14
摘要： Sterilization method using plasma for sterilizing objects, wherein it is provided to introduce the objects to be sterilized into a sterilization chamber (13) and covey toward the latter a flow of air coming from a feed pipe (17) on which a plasma generator device (12) is disposed able to generate one or more gaseous compounds comprising a mixture of reactive oxygen species (ROS) and of reactive nitrogen species (RNS) so that the air is the carrier fluid which conveys the gaseous compounds toward the sterilization chamber (13); the method also provides to control the electric power used to produce the plasma as a function of the composition and/or the quantity of reactive species present in the sterilization chamber (13).
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22.发明申请公开(公告)号：US20210163385A1
公开(公告)日：2021-06-03
申请号：US17044906
申请日：2019-04-04
发明人： Fabrizio CAVANI , Valerio ZANOTTI , Rita MAZZONI , Carlo LUCARELLI , Cristiana CESARI , Tommaso TABANELLI , Francesco PUZZO
摘要： A process for obtaining higher aliphatic alcohols starting from aliphatic primary alcohols by condensation reactions is disclosed. Specifically, the process comprises a step in which an aliphatic primary alcohol is contacted in a homogeneous phase with a catalyst mixture comprising a transition metal, a base and an additive; specifically, this additive can be selected from the classes of compounds of the isoquinolines N-oxide, quinolines N-oxide, pyridines N-oxide, benzoquinones, naphthoquinones, or TEMPO. In particular, the process can be carried out by contacting said aliphatic primary alcohol with a catalyst of a recycled transition metal, with a freshly added base and with a recycled additive of the aforementioned type.
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公开(公告)号：US20210146293A1
公开(公告)日：2021-05-20
申请号：US17046741
申请日：2019-03-25
发明人： Cesare SACCANI , Augusto BIANCHINI
摘要： The present invention relates to a method and to an apparatus for separating an exhaust gas, in particular an exhaust gas of a boiler, comprising introducing a gas stream of exhaust gas inside a washing chamber, dispensing a pressurized liquid shaped as drops inside the washing chamber, wherein the delivery pressure is adjusted according to the specific particulate to be separated so as to provide, during the separating step, a physical interaction between the delivered liquid drops and the particulate particles.
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公开(公告)号：US11007236B2
公开(公告)日：2021-05-18
申请号：US16307683
申请日：2017-06-08
IPC分类号： A61K35/763 , C07K14/035 , C07K14/47 , C12N5/10 , C12N7/00 , C12N15/62 , C12N15/86
摘要： The present invention is directed to a recombinant herpesvirus comprising a heterologous polypeptide ligand capable of binding to a target molecule and fused to or inserted into glycoprotein B at specific sites. The herpesvirus may comprise more than one ligand, and the additional ligand(s) may be comprised by a modified glycoprotein D and/or modified glycoprotein H. This allows the herpesvirus to target a cell for therapeutic purposes, and a cell for virus production. The present invention further comprises a pharmaceutical composition comprising the herpesvirus, the herpesvirus for use in the treatment of a tumor, infection, degenerative disorder or senescence-associated disease, a nucleic acid and a vector coding for the gB, a polypeptide comprising the gB, and a cell comprising the herpesvirus, nucleic acid, vector or polypeptide. Moreover, a method for infecting a cell with the herpesvirus or for producing the herpesvirus is disclosed.
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公开(公告)号：US10889560B2
公开(公告)日：2021-01-12
申请号：US16472593
申请日：2017-12-15
申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA , ALMA MATER STUDIORUM—UNIVERSITA' DI BOLOGNA , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： Marco De Vivo , Jose Antonio Ortega Martinez , Jose Manuel Arencibia Jimenez , Anna Minarini , Claudia Sissi
IPC分类号： C07D401/04 , A61K33/243 , A61K31/167 , A61K31/282 , A61K31/337 , A61K31/357 , A61K31/407 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/655 , A61K31/704 , A61K31/706 , A61K31/7076 , C07D471/04
摘要： The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).
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公开(公告)号：US20200325095A1
公开(公告)日：2020-10-15
申请号：US16765983
申请日：2018-11-22
发明人： Fabrizio Cavani , Andrea Vassoi
IPC分类号： C07C51/245 , C11C3/00 , B01J31/28
摘要： The present invention relates to a process of preparation of carboxylic acids by oxidative cleavage of at least one vicinal diol or an epoxide in the presence of an oxidant comprising molecular oxygen and a heterogeneous catalyst comprising a copper oxide.
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27.发明授权公开(公告)号：US10745536B2
公开(公告)日：2020-08-18
申请号：US15576459
申请日：2016-05-19
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITÉ CLERMONT AUVERGNE , ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA , ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE CLERMONT FERRAND
发明人： Fabrice Leroux , Vincent Verney , Laura Sisti , Annamaria Celli , Grazia Totaro
IPC分类号： C08K3/22 , C09C1/00 , C01F7/00 , C01B13/36 , C01G9/00 , C09C1/40 , C01F1/00 , C01F7/02 , C08K5/134 , C08L35/00 , C08L67/00
摘要： Layered double hydroxides organo-modified by 3-(4-hydroxyphenyl)propionic acid (HPPA), by 2-(4-hydroxyphenyl)ethylsulfonic acid or by a hydroxyphenylpropenoic acid, and to composite polymer materials having same. The composite materials are advantageously made of biosourced polymers such as poly(butylene succinate). These composite materials have improved properties over the polymers that make up the composition thereof, and over the composites of the prior art.
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公开(公告)号：US20190083454A1
公开(公告)日：2019-03-21
申请号：US16131310
申请日：2018-09-14
发明人： Renata Bartesaghi , Fiorenza Stagni
IPC分类号： A61K31/352 , A61P25/00
摘要： The present invention relates to methods of restoring brain development in individuals with Down syndrome with a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF).
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29.发明授权公开(公告)号：US09744199B2
公开(公告)日：2017-08-29
申请号：US14864098
申请日：2015-09-24
IPC分类号： A61K35/00 , A61K35/76 , A61K49/04 , C07K14/005 , C12N7/00 , A61K39/245 , C07K14/035 , A61K35/763
CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407
摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
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公开(公告)号：US08075625B2
公开(公告)日：2011-12-13
申请号：US12159474
申请日：2006-12-28
IPC分类号： A61F2/38
CPC分类号： A61F2/38 , A61F2/08 , A61F2/3804 , A61F2/40 , A61F2/4202 , A61F2002/30639 , A61F2002/30934 , A61F2002/30945
摘要： An orthopaedic device (1) for the mobile connection of a first and a second bony segment (4, 5) of an organic device for cooperating with or substituting a natural articulation comprising a first working surface (9) related to the first cooperating segment (4) with a second working surface (10) related to the second bony segment (5) in order to constrain (guide) the relative motion between the said bony segments (4, 5); the first and the second working surface (9, 10) are respectively practically shaped as the axodes of the relative motion of a first and a second link of a linkage practically equivalent to the natural articulation; in particular the first and the second link are corresponding, in the linkage, to the first and the second bony segment (4, 5).
摘要翻译： 一种用于与有机装置的第一和第二骨段（4,5）的移动连接的矫形装置（1），用于与自然关节相配合或替代自然关节，包括与第一协作部分相关的第一工作表面（9） 4），其具有与所述第二骨段（5）相关的第二工作表面（10），以限制（引导）所述骨段（4,5）之间的相对运动; 第一和第二工作表面（9,10）分别实际上成形为实际上等同于自然关节的连杆的第一和第二连杆的相对运动的轴向; 特别地，第一和第二连杆在连接时对应于第一和第二骨段（4,5）。
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