公开(公告)号：US10064939B2

公开(公告)日：2018-09-04

申请号：US14949041

申请日：2015-11-23

Applicant: Samsung Electronics Co., Ltd. ,  Yonsei University, University-Industry Foundation (UIF)

Inventor： Seon Hui Shim ,  Ji Min Lee ,  Soo Yeon Jung ,  Woo Sun Kwon ,  Kyung Ah Kim ,  Jeong Min Kim ,  Sun Young Rha ,  Won Suk Lee

IPC: A61K39/395 ,  A61K31/00 ,  C07K16/28 ,  A61K31/4985 ,  G01N33/574 ,  G01N33/74 ,  A61K39/00

Abstract: A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met (hereinafter, ‘c-Met inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met inhibitor.

公开(公告)号：US09192666B2

公开(公告)日：2015-11-24

申请号：US14242684

申请日：2014-04-01

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo Gyou Kim ,  Ji Min Lee ,  Kyung Ah Kim ,  Yun Ju Jeong

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  A61K31/506 ,  A61K31/519 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/506 ,  A61K31/519 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Provided is a method for prevention or treatment of a cancer, comprising co-administering (a) an FGFR inhibitor and (b) an anti-c-Met antibody or antigen-binding fragment thereof to a subject in need thereof, wherein the anti-c-Met antibody or the antigen-binding fragment thereof specifically binds to an epitope comprising 5 or more contiguous amino acids within the SEMA domain of c-Met protein.

Abstract translation: 本发明提供一种预防或治疗癌症的方法，其包括将（a）FGFR抑制剂和（b）抗c-Met抗体或其抗原结合片段共同给予有需要的受试者，其中， c-Met抗体或其抗原结合片段特异性结合到c-Met蛋白的SEMA结构域内包含5个或更多个连续氨基酸的表位。

公开(公告)号：US20150140014A1

公开(公告)日：2015-05-21

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K14/71 ,  A61K31/437 ,  A61K31/44 ,  A61K39/395 ,  A61K31/517

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

Abstract translation: 一种预防或治疗癌症的方法，包括共同给予（a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种， （a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种提供给药物组合物 。

公开(公告)号：US20150071932A1

公开(公告)日：2015-03-12

申请号：US14481509

申请日：2014-09-09

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ji Min Lee ,  Kyung Ah Kim

IPC: A61K39/395 ,  A61K31/7088

CPC classification number: A61K31/7088 ,  A61K31/713 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  A61K2300/00

Abstract: A method of preventing and/or treating a cancer including co-administering a c-Met inhibitor and a c-Myc Inhibitor to a subject in need thereof, a pharmaceutical composition comprising a c-Met inhibitor and a c-Myc inhibitor, and a kit comprising a pharmaceutically effective amount of a c-Met inhibitor as an active ingredient, and a second pharmaceutical composition comprising a pharmaceutically effective amount of a c-Myc inhibitor as an active ingredient, packaged together.

Abstract translation: 一种预防和/或治疗癌症的方法，包括向有需要的受试者共同施用c-Met抑制剂和c-Myc抑制剂，包含c-Met抑制剂和c-Myc抑制剂的药物组合物和 试剂盒包含药学上有效量的c-Met抑制剂作为活性成分，以及包含药学有效量的作为活性成分的c-Myc抑制剂的第二药物组合物，包装在一起。

公开(公告)号：US11023201B2

公开(公告)日：2021-06-01

申请号：US16259669

申请日：2019-01-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： In Jong Rhee ,  Ji Min Lee ,  Sang Ki Kang ,  Han Jun Ku ,  Sung Pa Park ,  Jang Seok Seo ,  In Wook Song ,  Won Ick Ahn ,  Kyoung Gu Woo ,  Ji Soo Yi ,  Chang Kyun Jeon ,  Ho Jun Jaygarl ,  Il Hwan Choi ,  Yoo Jin Hong ,  Ji Hyun Kim ,  Jae Yung Yeo

IPC: G06F3/16 ,  G10L15/26 ,  G06F9/451 ,  G06F3/0481 ,  G06F3/0482 ,  G06F3/0488 ,  G10L15/18 ,  G10L15/22 ,  G10L15/30 ,  H04R1/02

Abstract: An electronic device is provided. The electronic device includes a housing, a touchscreen display exposed through a first portion of the housing, a microphone disposed at a second portion of the housing, a speaker disposed at a third portion of the housing, a memory disposed inside the housing, a processor disposed inside the housing, and electrically connected to the display, the microphone, the speaker, and the memory. The memory is configured to store a plurality of application programs, each of which includes a graphic user interface (GUI).

公开(公告)号：US10191718B2

公开(公告)日：2019-01-29

申请号：US15824331

申请日：2017-11-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： In Jong Rhee ,  Ji Min Lee ,  Sang Ki Kang ,  Han Jun Ku ,  Sung Pa Park ,  Jang Seok Seo ,  In Wook Song ,  Won Ick Ahn ,  Kyoung Gu Woo ,  Ji Soo Yi ,  Chang Kyun Jeon ,  Ho Jun Jaygarl ,  Il Hwan Choi ,  Yoo Jin Hong ,  Ji Hyun Kim ,  Jae Yung Yeo

IPC: G06F3/16 ,  G10L15/18 ,  G10L15/22 ,  G06F3/0481 ,  G06F3/0482 ,  G06F3/0488 ,  G10L15/26 ,  G10L15/30 ,  H04R1/02

Abstract: An electronic device is provided. The electronic device includes a housing, a touchscreen display exposed through a first portion of the housing, a microphone disposed at a second portion of the housing, a speaker disposed at a third portion of the housing, a memory disposed inside the housing, a processor disposed inside the housing, and electrically connected to the display, the microphone, the speaker, and the memory. The memory is configured to store a plurality of application programs, each of which includes a graphic user interface (GUI).

公开(公告)号：US09956244B2

公开(公告)日：2018-05-01

申请号：US14814278

申请日：2015-07-30

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ji Min Lee ,  Bo Gyou Kim ,  Seung Ja Oh ,  Kyung Ah Kim ,  Saet Byoul Lee ,  Jae Woong Hwang

IPC: G01N33/50 ,  G01N33/574 ,  A61K31/713 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

CPC classification number: A61K31/713 ,  A61K39/39533 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57484 ,  G01N2800/52 ,  A61K2300/00 ,  A61K31/573

Abstract: A biomarker Hsp90 for predicting an efficacy of a c-Met inhibitor, selecting a subject for application of a c-Met inhibitor, or monitoring an efficacy of a c-Met inhibitor, and a relevant method of using Hsp90.

公开(公告)号：US09931400B2

公开(公告)日：2018-04-03

申请号：US14025403

申请日：2013-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju Jeong ,  Kyung Ah Kim ,  Yun Jeong Song ,  Ji Min Lee ,  Hyo Seon Lee ,  Jae Hyun Choi ,  Saet Byoul Lee

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/24

Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.

公开(公告)号：US09808507B2

公开(公告)日：2017-11-07

申请号：US14835376

申请日：2015-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seungja Oh ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Seung Hyun Lee ,  Ji Min Lee

IPC: C07K16/22 ,  A61K38/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K38/18 ,  A61K38/1891 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.

公开(公告)号：US09717715B2

公开(公告)日：2017-08-01

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: A61K39/395 ,  A61K31/437 ,  A61K31/517 ,  A61K31/44 ,  C07K16/28 ,  C12N5/16

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.