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公开(公告)号：US20150140014A1
公开(公告)日：2015-05-21
申请号：US14081886
申请日：2013-11-15
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun LEE , Geun Woong Kim , Kyung Ah Kim , Hye Won Park , Ho Yeong Song , Young Mi Oh , Saet Byoul Lee , Ji Min Lee , Kwang Ho Cheong , Yun Ju Jeong , Mi Young Cho , Jae Hyun Choi , Yun Jeong Song , Yoon Aa Choi
IPC: C07K14/71 , A61K31/437 , A61K31/44 , A61K39/395 , A61K31/517
CPC classification number: A61K31/437 , A61K31/44 , A61K31/517 , A61K39/3955 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30 , C12N5/163 , A61K2300/00
Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.
Abstract translation: 一种预防或治疗癌症的方法，包括共同给予（a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种， （a）抗c-Met抗体或其抗原结合片段，和（b）拉帕替尼，替罗非尼，伏马拉净或其组合中的至少一种提供给药物组合物 。
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公开(公告)号：US10393748B2
公开(公告)日：2019-08-27
申请号：US14591787
申请日：2015-01-07
Applicant: Samsung Electronics Co., Ltd.
Inventor： Soo Yeon Jung , Seon Hui Shim , Yun Jeong Song , Hyeon-seok Yoo
IPC: G01N33/50 , G01N33/574 , C07K16/40 , C12Q1/6886 , A61K39/00
Abstract: A biomarker for predicting and/or monitoring the efficacy of a c-Met inhibitor; a composition for predicting and/or monitoring the efficacy of a c-Met inhibitor, comprising a material detecting the biomarker; a composition for selecting a subject suitable for the application of a c-Met inhibitor, comprising a material detecting the biomarker; a method for predicting and/or monitoring the efficacy of a c-Met inhibitor using the biomarker; a method for selecting a subject suitable for the application of a c-Met inhibitor using the biomarker; and a method for preventing and/or treating cancer comprising administering a c-Met inhibitor to the selected subject.
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Patent Agency Ranking
公开(公告)号：US10214593B2
公开(公告)日：2019-02-26
申请号：US14243751
申请日：2014-04-02
Applicant: SAMSUNG ELECTRONICS CO., LTD.
Inventor： Soo Yeon Jung , Yun Jeong Song , Mi Young Cho , Han Na Choi
Abstract: Disclosed are an anti-idiotype antibody that specifically binds to an idiotope site of an anti-c-Met antibody, the use of the anti-idiotype antibody for detecting the anti-c-Met antibody, and methods, polypeptides, polynucleotides, compositions, and vaccines related thereto.
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公开(公告)号：US09931400B2
公开(公告)日：2018-04-03
申请号：US14025403
申请日：2013-09-12
Applicant: Samsung Electronics Co., Ltd.
Inventor： Yun Ju Jeong , Kyung Ah Kim , Yun Jeong Song , Ji Min Lee , Hyo Seon Lee , Jae Hyun Choi , Saet Byoul Lee
IPC: A61K39/395 , A61K45/06 , C07K16/28
CPC classification number: A61K39/3955 , A61K45/06 , C07K16/2863 , C07K2317/24
Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.
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公开(公告)号：US09717715B2
公开(公告)日：2017-08-01
申请号：US14081886
申请日：2013-11-15
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Geun Woong Kim , Kyung Ah Kim , Hye Won Park , Ho Yeong Song , Young Mi Oh , Saet Byoul Lee , Ji Min Lee , Kwang Ho Cheong , Yun Ju Jeong , Mi Young Cho , Jae Hyun Choi , Yun Jeong Song , Yoon Aa Choi
IPC: A61K39/395 , A61K31/437 , A61K31/517 , A61K31/44 , C07K16/28 , C12N5/16
CPC classification number: A61K31/437 , A61K31/44 , A61K31/517 , A61K39/3955 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30 , C12N5/163 , A61K2300/00
Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.
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公开(公告)号：US09650443B2
公开(公告)日：2017-05-16
申请号：US14228521
申请日：2014-03-28
Applicant: Samsung Electronics Co., Ltd.
Inventor： Yun Jeong Song , Ho Yeong Song , Seung Hyun Lee , Kyung Ah Kim , Yun Ju Jeong
CPC classification number: C07K16/2863 , A61K2039/505 , C07K14/71 , C07K2317/10 , C07K2317/24 , C07K2317/515 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.
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公开(公告)号：US20140154251A1
公开(公告)日：2014-06-05
申请号：US14081917
申请日：2013-11-15
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun LEE , Geun Woong Kim , Kyung Ah Kim , Hye Won Park , Ho Yeong Song , Young Mi Oh , Saet Byoul Lee , Ji Min Lee , Kwang Ho Cheong , Yun Ju Jeong , Mi Young Cho , Jae Hyun Choi , Yun Jeong Song , Yoon Aa Choi
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92
Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.
Abstract translation: 提供了抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。
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