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公开(公告)号：US3959254A
公开(公告)日：1976-05-25
申请号：US414010
申请日：1973-11-08
Applicant: Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
Inventor： Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
CPC classification number: C07G11/00 , C07H15/22 , Y10S435/863
Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
Abstract translation: 本文命名为小单孢菌（Rhodomonic）的新颖放线菌制备了具有显着抗菌活性的产品，所述活性主要是由于本文命名为抗生素G-418的新型抗生素。 本公开阐述了生产，分离和使用所述抗生素的方法。
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公开(公告)号：US4677071A
公开(公告)日：1987-06-30
申请号：US638189
申请日：1984-08-06
Applicant: May D. Lee , John H. Martin , Donald B. Borders , Raymond C. Yao , Raymond T. Testa
Inventor： May D. Lee , John H. Martin , Donald B. Borders , Raymond C. Yao , Raymond T. Testa
CPC classification number: C12P1/06 , Y10S435/886
Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
Abstract translation: 本发明涉及在微生物发酵过程中，在控制条件下，使用新的菌株Streptomyces coeruleorubidus subspecies rubidus，命名为LL-BO2964α，LL-BO2964β，LL-BO2964γ的新型多肽抗生素及其名称为LL-BO2964的混合物 或其突变体。 新的抗生素对各种微生物有活性，也可用于治疗结核病。
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23.发明授权Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega..sub.1, LL-D49194.omega..sub.2, and LL-D49194.omega..sub.3 失效抗肿瘤剂LL-D49194α1，LL-D49194β1，LL-D49194β2，LL-D49194β3，LL-D49194γ，LL-D49194δ，LL-D49194ε，LL-D49194 xi，LL-D49194 eta ，LL-D49194 omega1，LL-D49194 omega2和LL-D49194ω3
公开(公告)号：US4626503A
公开(公告)日：1986-12-02
申请号：US701831
申请日：1985-02-14
Applicant: May D. Lee , Amedeo A. Fantini , David P. Labeda , William M. Maiese , Raymond T. Testa , Donald B. Borders
Inventor： May D. Lee , Amedeo A. Fantini , David P. Labeda , William M. Maiese , Raymond T. Testa , Donald B. Borders
Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
Abstract translation: 抗肿瘤剂LL-D49194α1，LL-D49194β1，LL-D49194β2，LL-D49194β3，LL-D49194γ，LL-D49194δ，LL-D49194ε，LL-D49194 xi，LL-D49194 eta ，LL-D49194欧米加，LL-D49194 omega2和LL-D49194ω3。
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公开(公告)号：US4503044A
公开(公告)日：1985-03-05
申请号：US488496
申请日：1983-04-25
Applicant: May D. Lee , Donald B. Borders , David P. Labeda , Amedeo A. Fantini , Raymond T. Testa
Inventor： May D. Lee , Donald B. Borders , David P. Labeda , Amedeo A. Fantini , Raymond T. Testa
IPC: C07G11/00 , A61K35/74 , A61K38/00 , A61P31/04 , A61P35/00 , C07K5/06 , C12P1/04 , C12R1/01 , A61K37/00 , C07C103/52
CPC classification number: C07K5/06026 , C12R1/01 , A61K38/00
Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
Abstract translation: 本公开描述了一种名为LL-D05139β的新型抗细菌剂和抗肿瘤剂，其在微生物发酵下，在控制条件下使用新的Glycomyces harbinensis gen。 诺夫山脉 nov。及其突变体。
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公开(公告)号：US3997403A
公开(公告)日：1976-12-14
申请号：US621266
申请日：1975-10-10
Applicant: Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
Inventor： Marvin J. Weinstein , Gerald H. Wagman , Raymond T. Testa , Joseph A. Marquez
CPC classification number: C07G11/00 , C07H15/22 , Y10S435/863
Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
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Patent Agency Ranking26.发明授权Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian species 失效控制禽类物种慢性呼吸道疾病，禽霍乱和坏死性肠炎的方法
公开(公告)号：US4968493A
公开(公告)日：1990-11-06
申请号：US371666
申请日：1989-06-19
Applicant: Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
Inventor： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
IPC: A23K20/195 , C12P1/06
CPC classification number: C12P1/06 , A23K20/195
Abstract: This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.
Abstract translation: 本发明提供一种通过口服给药药用有效量的抗生素LL-E19020α，抗生素LL-E19020β或其生理上可接受的盐来治疗感染禽类的慢性呼吸道疾病，家禽霍乱和坏死性肠炎的方法。
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公开(公告)号：US4870019A
公开(公告)日：1989-09-26
申请号：US933651
申请日：1986-11-21
Applicant: Jane P. Kirby , Donald B. Borders , May D. Lee , William M. Maiese , Raymond T. Testa , David P. Labeda
Inventor： Jane P. Kirby , Donald B. Borders , May D. Lee , William M. Maiese , Raymond T. Testa , David P. Labeda
IPC: C12P1/06
CPC classification number: C12P1/06 , Y10S435/822
Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
Abstract translation: 描述了一种名为LL-C19004的新型抗菌剂，该抗菌剂通过微生物发酵，在控制条件下使用新品种的Saccharothrix，Saccharothrix espanaensis（NRRL 15764）产生。
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28.发明授权Biologically pure culture of Streptoverticillium stramineum sp. nov. 失效生物学纯培养Streptoverticillium stramineum sp。 nov。
公开(公告)号：US4650765A
公开(公告)日：1987-03-17
申请号：US760870
申请日：1985-07-30
Applicant: Jane P. Kirby , Amedeo A. Fantini , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
Inventor： Jane P. Kirby , Amedeo A. Fantini , Donald B. Borders , Raymond T. Testa , John H. E. J. Martin, deceased
Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
Abstract translation: 本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。
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29.发明授权Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp. nov. 失效从哈尔滨红豆from酵母的培养物制备抗生素LL-D05139β。 诺夫山脉 nov。
公开(公告)号：US4568646A
公开(公告)日：1986-02-04
申请号：US694567
申请日：1985-01-24
Applicant: May D. Lee , Donald B. Borders , David P. Labeda , Amedeo A. Fantini , Raymond T. Testa
Inventor： May D. Lee , Donald B. Borders , David P. Labeda , Amedeo A. Fantini , Raymond T. Testa
CPC classification number: C07K5/06026 , C12R1/01 , A61K38/00 , Y10S435/822 , Y10S435/826 , Y10S435/872
Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
Abstract translation: 本公开描述了一种名为LL-D05139β的新型抗细菌剂和抗肿瘤剂，其在微生物发酵下，在控制条件下使用新的Glycomyces harbinensis gen。 诺夫山脉 nov。及其突变体。
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30.发明授权Antibiotic LL-BO1208.alpha. and LL-BO1208.beta., process of preparation, pharmaceutical composition and method of use 失效抗生素LL-BO1208α和LL-BO1208β，制备方法，药物组合物和使用方法
公开(公告)号：US4552867A
公开(公告)日：1985-11-12
申请号：US510694
申请日：1983-07-05
Applicant: John H. E. J. Martin , Jane P. Kirby , Donald B. Borders , Amedeo A. Fantini , Raymond T. Testa
Inventor： John H. E. J. Martin , Jane P. Kirby , Donald B. Borders , Amedeo A. Fantini , Raymond T. Testa
IPC: C12N1/20 , A61K35/74 , A61P31/04 , A61P35/00 , C07G11/00 , C07K9/00 , C12P1/06 , C12P19/58 , C12R1/625 , A61K37/02 , A61K31/71 , C12P19/12 , C12P21/02
CPC classification number: C12R1/625 , C07K9/003 , C12P1/06 , C12P19/58 , Y10S930/19
Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
Abstract translation: 本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。
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