公开(公告)号：US4628046A

公开(公告)日：1986-12-09

申请号：US506170

申请日：1983-06-20

Applicant: David P. Labeda ,  Joseph J. Goodman ,  John H. E. J. Martin, deceased

Inventor： David P. Labeda ,  Joseph J. Goodman ,  John H. E. J. Martin, deceased

IPC: C07H19/01 ,  C12P19/44 ,  A61K31/71

CPC classification number: C07H19/01 ,  C12P19/44 ,  C12P19/445 ,  C12R1/465

Abstract: This disclosure describes a new antibacterial agent designated LL-C23201.delta., produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces olivaceo-griseus, sp. nov. and mutants thereof. This new antibacterial agent is active against a variety of microorganisms and thus is useful in inhibiting the growth of such bacteria wherever they may be found.

Abstract translation: 本公开描述了一种称为LL-C23201δ的新的抗菌剂，其在微生物发酵中在受控条件下使用新的菌株Streptomyces olivaceo-griseus，sp。 nov。 及其突变体。 这种新的抗菌剂对各种微生物具有活性，因此可用于抑制这些细菌的生长。

公开(公告)号：US4608343A

公开(公告)日：1986-08-26

申请号：US739334

申请日：1985-05-30

Applicant: David P. Labeda ,  Joseph J. Goodman ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

Inventor： David P. Labeda ,  Joseph J. Goodman ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

IPC: C12P1/06 ,  C12P21/00 ,  C12P13/00

CPC classification number: C12P1/06

Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.

Abstract translation: 本公开描述了在受控条件下使用新型链霉菌属的新菌株在微生物发酵中产生的四种新的抗菌剂，称为LL-C08078α1，LL-C08078α2，LL-C08078α3和LL-C08078ββ 称为Streptomyces majorciensis Labeda，sp。 nov。及其突变体。 这些新的抗菌剂对各种微生物具有活性，因此可用于抑制这些细菌的生长。 此外，这些试剂在温血动物中作为生长促进剂是有活性的。

公开(公告)号：US4534970A

公开(公告)日：1985-08-13

申请号：US507184

申请日：1983-06-23

Applicant: David P. Labeda ,  Joseph J. Goodman ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

Inventor： David P. Labeda ,  Joseph J. Goodman ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

IPC: C12P1/06 ,  A61K35/74

CPC classification number: C12P1/06

Abstract: This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.

Abstract translation: 本公开描述了在受控条件下使用新型链霉菌属的新菌株在微生物发酵中产生的四种新的抗菌剂，称为LL-CO8078α1，LL-CO8078α2，LL-CO8078α3和LL-CO8078β 称为Streptomyces majorciensis Labeda，sp。 nov。及其突变体。 这些新的抗菌剂对各种微生物具有活性，因此可用于抑制这些细菌的生长。 此外，这些试剂在温血动物中作为生长促进剂是有活性的。

公开(公告)号：US4650765A

公开(公告)日：1987-03-17

申请号：US760870

申请日：1985-07-30

Applicant: Jane P. Kirby ,  Amedeo A. Fantini ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

Inventor： Jane P. Kirby ,  Amedeo A. Fantini ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

IPC: C07K9/00 ,  C12P1/06 ,  C12P19/58 ,  C12P19/12 ,  C12P21/02

CPC classification number: C12R1/625 ,  C07K9/003 ,  C12P1/06 ,  C12P19/58

Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.

Abstract translation: 本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。