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21.发明授权Substituted phenylalkenoylguanidines, process for their preparation, and their use in medicaments and in diagnostics 有权取代的苯基烯酰基胍，其制备方法及其在药物和诊断中的应用
公开(公告)号：US6166002A
公开(公告)日：2000-12-26
申请号：US422146
申请日：1999-10-20
Applicant: Andreas Weichert , Alfons Enhsen , Eugene Falk , Hans-Willi Jansen , Werner Kramer , Jan-Robert Schwark , Hans Jochen Lang
Inventor： Andreas Weichert , Alfons Enhsen , Eugene Falk , Hans-Willi Jansen , Werner Kramer , Jan-Robert Schwark , Hans Jochen Lang
CPC classification number: C07J41/0055 , C07J9/005 , C07J41/0061
Abstract: Substituted phenylalkenoylguanidines, processes for their preparation, uses as medicaments or diagnostics, and medicaments containing them are described.The invention relates to substituted phenylalkenoylguanidines and their pharmaceutically tolerable salts and physiologically functional derivatives of the formula ##STR1## in which the radicals have the meanings indicated, and their physiologically tolerable salts and processes for their preparation. The compounds are suitable as medicaments for the prophylaxis or treatment of gallstones.
Abstract translation: 描述了取代的苯基烯酰基胍，其制备方法，用作药物或诊断剂，以及含有它们的药物。 本发明涉及取代的苯基烯酰基胍及其药学上可耐受的盐和具有所述含义的基团的生理功能衍生物及其生理上可耐受的盐及其制备方法。 该化合物适用于预防或治疗胆结石的药物。
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22.发明授权Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments 失效单体胆汁酸衍生物，其制备方法和这些化合物作为药物的用途
公开(公告)号：US5610151A
公开(公告)日：1997-03-11
申请号：US238749
申请日：1994-05-05
Applicant: Heiner Glombik , Alfons Enhsen , Werner Kramer , G unther Wess
Inventor： Heiner Glombik , Alfons Enhsen , Werner Kramer , G unther Wess
IPC: A61K31/575 , A61K31/58 , A61P3/06 , A61P9/10 , C07J9/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J51/00 , A61K31/585 , C07J17/00
CPC classification number: C07J51/00 , C07J31/006 , C07J41/0055 , C07J41/0088 , C07J43/003 , C07J9/005
Abstract: Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicamentsMonomeric bile acid derivatives of the formula IZ--X--GS I,in which GS, X and Z have the meanings given, and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
Abstract translation: 单体胆汁酸衍生物，其制备方法和这些化合物作为药物的用途描述了式IZ-X-GSI的单体胆汁酸衍生物，其中GS，X和Z具有给定的含义及其制备方法。 这些化合物具有有用的药理学性质，因此可以用作药物。
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公开(公告)号：US07786103B2
公开(公告)日：2010-08-31
申请号：US11872855
申请日：2007-10-16
Applicant: Werner Kramer , Wendelin Frick
Inventor： Werner Kramer , Wendelin Frick
IPC: A61K31/397 , C07K14/435 , C07D205/04 , C07D235/02
Abstract: The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors.
Abstract translation: 本发明描述了一种分离能够结合胆固醇和/或胆固醇摄取抑制剂的肠蛋白的方法。
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24.发明授权Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07674773B2
公开(公告)日：2010-03-09
申请号：US11155109
申请日：2005-06-17
Applicant: Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
Inventor： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
CPC classification number: C07D205/08 , C07F7/1804
Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
Abstract translation: 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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25.发明申请NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH CYCLOHEXYL GROUPS, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF 有权与环烯基组合取代的新的1,4-苯并四氢吡喃-1,1-二氧化物衍生物，其生产方法，含有化合物的药物及其用途公开(公告)号：US20100035962A1
公开(公告)日：2010-02-11
申请号：US12465920
申请日：2009-05-14
Applicant: Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
Inventor： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC: A61K31/38 , C07D409/12 , A61P3/10 , A61P25/28 , A61P25/18
CPC classification number: C07D337/08
Abstract: This Invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof.
Abstract translation: 本发明涉及用环己基取代的新的1,4-苯并噻吩-1-,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。
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Patent Agency Ranking
26.发明申请Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof 有权由苄基取代的新的1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20100035961A1
公开(公告)日：2010-02-11
申请号：US12465911
申请日：2009-05-14
Applicant: Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
Inventor： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC: A61K31/38 , C07D409/12 , A61P3/10 , A61P25/28 , A61P25/18
CPC classification number: C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
Abstract: This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
Abstract translation: 本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。
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27.发明申请NOVEL DIPHENYLAZETIDINONE SUBSTITUTED BY PIPERAZINE-1-SULFONIC ACID AND HAVING IMPROVED PHARMACOLOGICAL PROPERTIES 审中-公开由哌嗪-1-磺酸取代的新型二氢吡啶酮，具有改善的药理性质公开(公告)号：US20090264402A1
公开(公告)日：2009-10-22
申请号：US12432997
申请日：2009-04-30
Applicant: Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Claus-Dieter Graf , Wolfgang Schmider
Inventor： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Claus-Dieter Graf , Wolfgang Schmider
IPC: A61K31/496 , C07D403/12 , A61P3/06 , C07D413/12
CPC classification number: C07D295/205 , C07D205/08 , C07D263/22
Abstract: The invention therefore relates to the compound of the formula I or a pharmaceutically acceptable salt thereof, its pharmaceutically composition and uses.
Abstract translation: 因此，本发明涉及式I化合物或其药学上可接受的盐，其药物组合物和用途。
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公开(公告)号：US07435727B2
公开(公告)日：2008-10-14
申请号：US10635008
申请日：2003-08-06
Applicant: Werner Kramer , Wendelin Frick
Inventor： Werner Kramer , Wendelin Frick
IPC: A61K31/397 , C07K14/435 , C07D205/08 , C07D235/02
Abstract: The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors. Methods of identifying inhibitors of cholesterol uptake and related pharmaceuticals and methods of treatment also are described.
Abstract translation: 本发明描述了一种分离能够结合胆固醇和/或胆固醇摄取抑制剂的肠蛋白的方法。 还描述了鉴定胆固醇摄取抑制剂和相关药物的方法以及治疗方法。
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29.发明授权Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权酸基取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07388004B2
公开(公告)日：2008-06-17
申请号：US11643890
申请日：2006-12-22
Applicant: Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
Inventor： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC: C07D205/08 , C07F9/568 , A61K31/397 , A61P9/10 , A61P3/06
CPC classification number: C07D205/08
Abstract: One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
Abstract translation: 本发明的一个实施方案涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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30.发明申请Novel Thiophene Glycoside Derivatives, Processes for The Preparation, Medicaments Comprising These Compounds, and The Use Thereof 有权新型噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US20060293252A1
公开(公告)日：2006-12-28
申请号：US11464338
申请日：2006-08-14
Applicant: Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
Inventor： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
IPC: A61K31/7052 , C07H17/02
CPC classification number: A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
Abstract: Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
Abstract translation: 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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