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1.发明授权Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation 有权格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节公开(公告)号：US08017350B2
公开(公告)日：2011-09-13
申请号：US11464245
申请日：2006-08-14
CPC分类号： C07F9/657181 , G01N33/5041 , G01N33/566
摘要： The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC whereina] a mammalian cell is incubated with glimepiride;b] hcDIGs of the cells of a] are prepared;c] the hcDIGs from b] are incubated with a chemical compound;d] the activity of the GPI-PLC from the hcDIGs of c] is determined.
摘要翻译： 本发明涉及一种用于鉴定调节哺乳动物GPI-PLC的活性的化合物的方法，其中哺乳动物细胞与格列美脲一起孵育; b] a]的细胞的hcDIGs被制备; c]来自b]的hcDIGs与化合物一起温育; d]确定GPI-PLC从c]的hcDIGs的活动。
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2.发明授权Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途公开(公告)号：US07772429B2
公开(公告)日：2010-08-10
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： C07C229/08 , C07C229/12
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译： 本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。
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3.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07666848B2
公开(公告)日：2010-02-23
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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4.发明申请NOVEL 1,4-BENZOTHIEPIN-1, 1-DIOXIDE DERIVATIVES WITH IMPROVED PROPERTIES METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF 有权具有改进性质的新颖的1,4-苯并二氢吡喃-1,1-二氧化物衍生物，其制备方法，含有化合物的药物及其用途公开(公告)号：US20100035834A1
公开(公告)日：2010-02-11
申请号：US12465883
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
CPC分类号： C07H5/06 , C07D409/12
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译： 本发明涉及具有改进性质的新型1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。
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公开(公告)号：US07563888B2
公开(公告)日：2009-07-21
申请号：US11557310
申请日：2006-11-07
申请人： Joachim-Heiner Jendralla , Guenter Billen , Wendelin Frick , Bernd Junker , Theodor Andreas Wollman
发明人： Joachim-Heiner Jendralla , Guenter Billen , Wendelin Frick , Bernd Junker , Theodor Andreas Wollman
IPC分类号： C07D205/08 , C07D307/20 , C07F7/18 , C07C237/20 , C07C235/38
CPC分类号： C07D205/08 , Y02P20/55
摘要： The present invention is a process for the preparation of diphenylazetidinone derivatives of the formula (I) or forms thereof comprising the substituents X, R1 and/or R2 as defined herein. More specifically, the invention comprises methods for the preparation of these compounds by cyclization of certain β-amino carboxamides or β-amino carboxylic esters. These diphenylazetidinone compounds are useful in the treatment of high blood serum cholesterol levels and the maintenance of the reduced cholesterol levels achieved thereby.
摘要翻译： 本发明是制备式（I）的二苯并氮杂环丁酮衍生物或其形式的方法，其包含如本文所定义的取代基X，R 1和/或R 2。 更具体地，本发明包括通过环化某些β-氨基甲酰胺或β-氨基羧酸酯来制备这些化合物的方法。 这些二苯基氮杂环丁酮化合物可用于治疗高血清胆固醇水平和维持由此实现的降低的胆固醇水平。
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6.发明申请Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof 审中-公开具有改进性能的新型1,4-苯并硫氮杂-1,1-二氧化物衍生物，其制备方法，含有该化合物的药物及其用途公开(公告)号：US20080207592A1
公开(公告)日：2008-08-28
申请号：US11970293
申请日：2008-01-07
IPC分类号： A61K31/554 , C07D281/10 , A61P3/00
CPC分类号： C07D281/10
摘要： The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.
摘要翻译： 本发明涉及式（A）的化合物以及其生理上可接受的盐。 该化合物适合作为例如降血脂药。
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7.发明授权Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药剂学的用途公开(公告)号：US07399777B2
公开(公告)日：2008-07-15
申请号：US11097345
申请日：2005-04-04
申请人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
发明人： Heiner Glombik , Eugen Falk , Wendelin Frick , Stefanie Keil , Hans-Ludwig Schäfer , Lothar Schwink , Wolfgang Wendler
IPC分类号： C07D263/32 , A61K31/421
CPC分类号： C07D263/32 , C07D413/12
摘要： Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.
摘要翻译： 公开了二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 化合物包括其中基团如所定义的式I化合物及其生理上可接受的盐及其制备方法。 化合物通常具有降低脂质和/或甘油三酯的性质，并且适合于例如用于治疗脂质代谢紊乱，II型糖尿病和X综合症。
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8.发明授权Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权环取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07176194B2
公开(公告)日：2007-02-13
申请号：US10463807
申请日：2003-06-18
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07D227/00 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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9.发明授权Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权酸基取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07176193B2
公开(公告)日：2007-02-13
申请号：US10463388
申请日：2003-06-18
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07D227/00 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D205/08
摘要： One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula 1, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物：其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义。 本发明的其它实施方案涉及式1化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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10.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07101856B2
公开(公告)日：2006-09-05
申请号：US10616945
申请日：2003-07-11
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I: in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理上耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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