发明授权
US08017350B2 Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
有权
格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节
- 专利标题： Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
- 专利标题（中）： 格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节
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申请号： US11464245申请日： 2006-08-14
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公开(公告)号： US08017350B2公开(公告)日： 2011-09-13
- 发明人: Guenter Mueller , Wendelin Frick , Rudolf Schneider
- 申请人： Guenter Mueller , Wendelin Frick , Rudolf Schneider
- 申请人地址： DE Frankfurt am Main
- 专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址： DE Frankfurt am Main
- 代理商 J. Darrell Fontenot
- 优先权： EP04003897 20040220
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C12Q1/34
摘要：
The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC whereina] a mammalian cell is incubated with glimepiride;b] hcDIGs of the cells of a] are prepared;c] the hcDIGs from b] are incubated with a chemical compound;d] the activity of the GPI-PLC from the hcDIGs of c] is determined.
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