公开(公告)号：US20210311146A1

公开(公告)日：2021-10-07

申请号：US17301509

申请日：2021-04-05

Applicant: Case Western Reserve University ,  Government of the United States, as represented by the Secretary of Commerce ,  The Regents of the University of Colorado, a body corporate

Inventor： Kathryn Keenan ,  Megan Poorman ,  Rasim Boyacioglu ,  Mark A. Griswold

IPC: G01R33/50 ,  G01R33/56 ,  G01R33/385 ,  A61B5/00 ,  A61B5/055

Abstract: A method for temperature quantification using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a region of interest in a subject using an MRF pulse sequence with smoothly varying RF phase for MR resonant frequencies that is played out continuously. For each of a plurality of time intervals during acquisition of the MRF data the method further includes comparing a set of the MRF data associated with the time interval to an MRF dictionary to determine at least one quantitative parameter of the acquired MRF data, determining a temperature change based on the at least one quantitative parameter and generating a quantitative map of the temperature change in the region of interest. The region of interest can include aqueous and adipose tissue.

公开(公告)号：US20210123997A1

公开(公告)日：2021-04-29

申请号：US16603312

申请日：2018-04-06

Applicant: Case Western Reserve University

Inventor： Bhairav Bipin Mehta ,  Simone Coppo ,  Michael Twieg ,  Mark A. Griswold

IPC: G01R33/483 ,  G01R33/561 ,  G01R33/56

Abstract: Systems and methods are provided for acquiring imaging data from one or more resonance species that simultaneously produce individual magnetic resonance signals in a plurality of different slices. The data is acquired by simultaneously exciting, using a pTX RF coil array, a plurality of different slices such that at least some of the plurality of different slices are excited by transmitting RF energy from a subset of transmit channels in the pTX RF coil array. The method also includes comparing the data to a dictionary of signal evolutions to determine quantitative values for two or more parameters of the resonant species based, at least in part, on matching the data to a set of known signal evolutions stored in the dictionary. The method includes producing an image for each of the plurality of different slice locations, at least in part, on the quantitative values.

公开(公告)号：US10859654B2

公开(公告)日：2020-12-08

申请号：US16351404

申请日：2019-03-12

Applicant: Case Western Reserve University

Inventor： Vikas Gulani ,  Satyam Ghodasara ,  Katherine Wright ,  Nicole Seiberlich ,  Mark A. Griswold

IPC: G01R33/56 ,  G01R33/563 ,  A61B5/055 ,  G01R33/28 ,  G01R33/44

Abstract: A method for determining quantitative parameters for dynamic contrast-enhanced MR data includes acquiring a set of contrast-enhanced MR data for a region of interest using a T1-weighted pulse sequence, generating at least one contrast concentration curve based on the set of contrast-enhanced MR data, accessing a comprehensive dictionary of contrast concentration curves and generating a grouped dictionary that has a plurality of groups based on the comprehensive dictionary. Each group includes a plurality of correlated contrast concentration curves and a group representative signal for the group. The method also includes comparing a contrast concentration curve with the group representative signal of each group to select a group, comparing the contrast concentration curve to the plurality of correlated contrast concentration curves in the selected group to identify a set of quantitative parameters for the concentration curve and generating a report including the set of quantitative parameter.

公开(公告)号：USD888073S1

公开(公告)日：2020-06-23

申请号：US29671580

申请日：2018-11-28

Applicant: Case Western Reserve University

Designer： Mark A. Griswold

公开(公告)号：US20200158805A1

公开(公告)日：2020-05-21

申请号：US16686828

申请日：2019-11-18

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Cameron McIntyre

IPC: G01R33/56 ,  G01R33/48 ,  G01R33/50

Abstract: A method for target identification for a deep brain stimulation procedure includes acquiring a set of magnetic resonance fingerprinting (MRF) data for a region of interest in a subject using a MRI system, comparing the set of MRF data to an MRF dictionary to determine at least one parameter for the MRF data for the region of interest, generating a quantitative map of the at least one parameter, segmenting a target area of the region of interest based on the MRF data, generating at least one trajectory for placement of at least one electrode in the target area of the region of interest based on the segmentation of the target area and displaying the quantitative map and the at least one trajectory on a display.

公开(公告)号：US20190353731A1

公开(公告)日：2019-11-21

申请号：US16415474

申请日：2019-05-17

Applicant: Case Western Reserve University

Inventor： Yuchi Liu ,  Jesse Hamilton ,  Nicole Seiberlich ,  Mark A. Griswold

IPC: G01R33/50 ,  G01R33/54

Abstract: A method for quantifying T1, T2 and resonance frequency simultaneously using magnetic resonance fingerprinting (MRF) includes accessing an MRF dictionary using a magnetic resonance imaging (MRI) system. The MRF dictionary is generated by simulating signal evolutions that include associated off-resonance effects for each signal evolution. The method further includes acquiring MRF data from a region of interest in a subject using the MRI system and a MRF pulse sequence having a plurality of radio frequency (RF) excitations and a readout associated with each RF excitation. Each readout includes a plurality of segments and each segment is used to generate a time frame. The method also include comparing the MRF data to the MRF dictionary to identify a plurality of parameters including T1, T2 and resonance frequency for the MRF data and generating a report indicating the at least one of the plurality of parameters of the MRF data.

公开(公告)号：US20190046052A1

公开(公告)日：2019-02-14

申请号：US16159888

申请日：2018-10-15

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Anagha Deshmane ,  Jeffrey Sunshine

IPC: A61B5/026 ,  G01R33/48 ,  A61B5/055 ,  A61B5/00 ,  G01R33/44 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563 ,  G01R33/565 ,  A61B1/00 ,  G01R33/50 ,  A61B17/00 ,  G01R1/00 ,  G06T1/00

Abstract: Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing diseased tissue from healthy tissue based on tissue component fractions identified using the NMR fingerprinting.

公开(公告)号：USD838727S1

公开(公告)日：2019-01-22

申请号：US29601332

申请日：2017-04-21

Applicant: Case Western Reserve University

Designer： Mark A. Griswold

公开(公告)号：US20180292493A1

公开(公告)日：2018-10-11

申请号：US15945594

申请日：2018-04-04

Applicant: Case Western Reserve University

Inventor： Mark A. Griswold ,  Yun Jiang

IPC: G01R33/561 ,  G01R33/56 ,  G01R33/54 ,  G01R33/50 ,  G06T7/00

CPC classification number: G01R33/561 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/543 ,  G01R33/56 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of excitation volumes within a subject, wherein at least two of the plurality of excitation volumes differ in location within the subject, and wherein each of the excitation volumes partially overlap to form an overlap volume. The method also includes comparing the plurality of MRF signals acquired from the overlap volume with a dictionary of signal evolutions, determining one or more physical parameters of the overlap volume within the subject, and generating a report at least indicating the one or more physical parameters of the overlap volume within the subject.

公开(公告)号：US20180292483A1

公开(公告)日：2018-10-11

申请号：US15945714

申请日：2018-04-04

Applicant: Case Western Reserve University

Inventor： Vikas Gulani ,  Mark A. Griswold ,  Alice Yang ,  Yun Jiang

IPC: G01R33/48 ,  G01R33/561 ,  G01R33/565

Abstract: A system and method for performing magnetic resonance fingerprinting (MRF) is provided that includes performing a pulse sequence that is sensitive to field inhomogeneities to acquire a series of signal evolutions form a region of interest (ROI) of the subject to form MRF data. The method also includes varying field inhomogeneities across the ROI to acquire the series of signal evolutions, comparing the MRF data with an MRF dictionary to determine at least one tissue property of the subject in the ROI, and producing at least one map of the at least one tissue property.