公开(公告)号：US06877102B2

公开(公告)日：2005-04-05

申请号：US10013983

申请日：2001-12-10

申请人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

发明人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

IPC分类号： G06F13/40 ,  G06F1/04

CPC分类号： G06F13/4068

摘要： A chipset to support multiple CPU's and a layout method thereof. Those independent signal lines for delivering high frequency clock signals of the chipset are isolated from using by other signals without being multiplexed. Trace length of the independent signal line is shorter than that of the others. The spaces between the independent signal line and others are also larger than that between other signal lines. Signal transmission quality is significantly upgraded because the high frequency clock signal is not multiplexed and isolated from others.

摘要翻译： 支持多CPU的芯片组及其布局方法。 用于传送芯片组的高频时钟信号的这些独立信号线与其他信号的使用隔离而不被复用。 独立信号线的跟踪长度短于其他信号线。 独立信号线与其他信号线之间的空间也大于其他信号线之间的间隔。 信号传输质量显着升高，因为高频时钟信号不被复用并与其隔离。

公开(公告)号：US06696763B2

公开(公告)日：2004-02-24

申请号：US09990920

申请日：2001-11-13

申请人： Shu-Hui Chen ,  Hsiu-Tzu Chen

发明人： Shu-Hui Chen ,  Hsiu-Tzu Chen

IPC分类号： H01L2348

CPC分类号： H01L23/49816 ,  H01L23/50 ,  H01L2924/0002 ,  H01L2924/00

摘要： A solder ball allocation on a chip, and a method of the same are provided. The chip has a substrate, first solder balls and second solder balls. The first solder balls are located on a periphery of the substrate and arranged outwardly. The second solder balls are located in a central part of the substrate and arranged with several first geometric patterns that construct a second geometric pattern. The first geometric patterns are also arranged to divide the chip into several power source blocks. The conflict between the second solder balls and the power source blocks are analyzed to remove the second solder balls with conflicts. The power line can go through the middle directly to avoid the power source bypass, or other reasons that cause the chip unable to work stable. The invention divides the chip into several power source blocks without increase the chip volume and cost.

摘要翻译： 提供了芯片上的焊球分配及其方法。 芯片具有基板，第一焊球和第二焊球。 第一焊球位于衬底的周边并且向外布置。 第二焊球位于基板的中心部分，并布置成构成第二几何图案的几个第一几何图案。 第一几何图案也被布置成将芯片分成几个电源块。 分析第二焊球和电源块之间的冲突，以冲出第二焊球。 电源线可以直接通过中间，避免电源旁路，或导致芯片工作不稳定的其他原因。 本发明将芯片分成几个电源块，而不增加芯片的体积和成本。

公开(公告)号：US06384346B1

公开(公告)日：2002-05-07

申请号：US09688037

申请日：2000-10-12

申请人： Nai-Shung Chang ,  Ching-Fu Chuang ,  Hsiu-Wen Ho ,  Chia-Hsing Yuo ,  Shu-Hui Chen

发明人： Nai-Shung Chang ,  Ching-Fu Chuang ,  Hsiu-Wen Ho ,  Chia-Hsing Yuo ,  Shu-Hui Chen

IPC分类号： H01R909

CPC分类号： H05K7/1459 ,  H05K1/0216 ,  H05K2201/044 ,  H05K2201/09236

摘要： A trace layout of a printed circuit board (PCB) is provided with a north bridge, at least a peripheral component interconnect (PCI) slot, and an accelerate graphics port (AGP) slot. The PCB includes at least a first trace layer and a second trace layer under the first trace layer. The AGP slot is mounted between the north bridge and the PCI slot. The PCB further includes a number of first traces, and a number of second traces. The first traces are used for connecting the north bridge to the PCI slot while the second traces are used to connect the north bridge to the AGP slot. Some of the first traces are on the second trace layer under the AGP slot, while the other of the first traces are on the first trace layer or the second trace layer and trace aside the AGP slot. Most of the second traces are on the first trace layer and the other of the second traces are on the second trace layer.

摘要翻译： 印刷电路板（PCB）的迹线布局提供有北桥，至少外围组件互连（PCI）插槽和加速图形端口（AGP）插槽。 PCB包括至少第一迹线层和第一迹线层下的第二迹线层。 AGP插槽安装在北桥和PCI插槽之间。 PCB还包括多个第一迹线和多个第二迹线。 第一条迹线用于将北桥连接到PCI插槽，而第二条路径用于将北桥连接到AGP插槽。 一些第一个迹线位于AGP插槽下的第二个跟踪层上，而第一个迹线中的另一个迹线位于第一个跟踪层或第二个跟踪层上，并跟踪AGP插槽。 大多数第二迹线位于第一迹线层上，而第二迹线中的另一条迹线位于第二迹线层上。

公开(公告)号：US06377510B2

公开(公告)日：2002-04-23

申请号：US09756586

申请日：2001-01-09

申请人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

发明人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

IPC分类号： G11C700

CPC分类号： G06F13/1694

摘要： A memory control system for controlling write-enable signals. The memory control system has a first memory slot having a write-enable pin thereon, a second memory slot having a first write-enable pin and a second write-enable pin thereon and a control chipset having a write-enable pin and a dual-purpose write-enable/memory-parity-data pin thereon. The write-enable pin of the control chipset is connected to the write-enable pin of the first memory slot and the first write-enable pin of the second memory slot. The write-enable/memory-parity-data pin of the control chipset is connected to the second write-enable pin of the second memory slot. In this invention, since the design of the write-enable system is more flexible, length of trace line on a computer board can be greatly reduced. In addition, the system permits the incorporation of one cycle (1T) timing into design of memory access commands.

摘要翻译： 一种用于控制写使能信号的存储器控​​制系统。 存储器控制系统具有在其上具有写使能引脚的第一存储器插槽，其上具有第一写使能引脚和第二写使能引脚的第二存储器插槽以及具有写使能引脚和双引脚引脚的控制芯片组， 目的写入/存储器奇偶校验数据引脚。 控制芯片组的写使能引脚连接到第一存储器插槽的写使能引脚和第二存储器插槽的第一写使能引脚。 控制芯片组的写使能/存储器奇偶校验数据引脚连接到第二存储器插槽的第二写使能引脚。 在本发明中，由于写使能系统的设计更灵活，所以可以大大减少计算机板上的迹线长度。 此外，该系统允许将一个周期（1T）定时并入到存储器访问命令的设计中。

公开(公告)号：US06063958A

公开(公告)日：2000-05-16

申请号：US218613

申请日：1998-12-22

申请人： Kuang-Ruei Chen ,  Jih-Dar Hwang ,  Shu-Hui Chen

发明人： Kuang-Ruei Chen ,  Jih-Dar Hwang ,  Shu-Hui Chen

IPC分类号： C07C51/215 ,  C07B61/00 ,  C07C51/31 ,  C07C51/44 ,  C07C51/48 ,  C07C55/14 ,  C07C59/105 ,  C07C51/42

CPC分类号： C07C51/44 ,  C07C51/313 ,  C07C51/48

摘要： A method of recovering adipic acid and 6-hydroxycaproic acid from the waste solution of alkali metal salts of organic acids coming from the process of cyclohexane oxidation, which comprises:(i) basifying the reaction mixture coming from cyclohexane oxidation with an aqueous solution of an alkali-metal base so that the organic acids essentially comprising adipic acid and 6-hydroxycaproic acid therein, are saponified, extracting the formed alkali metal salts of organic acids from the mixture with water, then acidifying the aqueous extract comprising the alkali metal salts of organic acids to a pH value of 3 or lower with an aqueous solution of a protic inorganic acid, as a result, said aqueous extract is separated into an oily layer and an aqueous layer;(ii) extracting the organic acid from said oily layer obtained from the step (i) with an aqueous solution of a protic inorganic acid, to obtain an aqueous extract;(iii) extracting the organic acid from the aqueous layer obtained from the step (i) with an organic solvent selected from alcohols, ketones, esters or the mixtures thereof, to obtain an oily extract;(iv) extracting the organic acid from the aqueous extract obtained from the step (ii) with an organic solvent selected from alcohols, ketones, esters or mixtures thereof, to obtain an oily extract; and(v) combining and distilling the oily extracts obtained from the steps (iii) and (iv), to recover the organic acid essentially comprising adipic acid and 6-hydroxycaproic acid.

摘要翻译： 从环己烷氧化方法的有机酸的碱金属盐的废溶液中回收己二酸和6-羟基己酸的方法，该方法包括：（i）将来自环己烷氧化的反应混合物用 碱金属碱，使得其中主要含有己二酸和6-羟基己酸的有机酸被皂化，从水中与混合物中提取形成的有机酸碱金属盐，然后酸化含有机碱的碱金属盐的含水提取物 酸与酸性无机酸的水溶液的pH值为3以下，结果将所述含水提取物分离成油层和水层; （ii）用质子性无机酸的水溶液从所述步骤（i）得到的所述油层中提取有机酸，得到水提取物; （iii）使用选自醇，酮，酯或其混合物的有机溶剂从由步骤（ⅰ）获得的水层萃取有机酸，得到油状提取物; （iv）用选自醇，酮，酯或其混合物的有机溶剂从步骤（ii）获得的水提取物中萃取有机酸，得到油状提取物; 和（v）合并并蒸馏由步骤（iii）和（iv）得到的油状提取物，以回收基本上包含己二酸和6-羟基己酸的有机酸。

公开(公告)号：US6005097A

公开(公告)日：1999-12-21

申请号：US663674

申请日：1996-06-14

申请人： Shu-Hui Chen ,  Xiuyan Li

发明人： Shu-Hui Chen ,  Xiuyan Li

IPC分类号： C07D307/33 ,  C07F7/18 ,  C07H19/00 ,  C07H19/048 ,  C07H19/06 ,  C07H19/16 ,  C07H19/22 ,  C07H19/04

CPC分类号： C07H19/06 ,  C07F7/1892 ,  C07H19/16

摘要： The present invention relates to methods for substantially enhancing the stereoselective synthesis of .beta.-anomeric nucleoside analogs. In methods according to the present invention, the introduction of a phenylseleno group onto a blocked lactone sugar precursor may be selected so that the desirable phenylseleno substituent is introduced on the side of the blocked lactone away from the blocking group. This stereospecific introduction of the phenylseleno group in sugar precursor allows the synthesis of nucleoside analogs and in particular, 2',3',-dideoxy- and 2',3'-dideoxy-2',3'-didehydronucleoside analogs in very high yield. In certain preferred embodiments, the preferred phenylseleno blocked lactone is obtained in an amount representing approximately 90% or more of the total amount of the stereoisomers obtained. In even more preferred embodiments, the amount of the preferred stereoisomer is at least 95%, even more preferably at least about 97% of the total amount of phenylseleno blocked lactone produced.

摘要翻译： 本发明涉及用于基本上增强β-异头核苷类似物的立体选择性合成的方法。 在根据本发明的方法中，可以选择在封端的内酯糖前体上引入苯基硒基团，使得所需的苯基硒取代基被引入封闭的内酯的远离阻断基团的一侧。 苯基硒基团在糖前体中的这种立体特异性引入允许以非常高的产率合成核苷类似物，特别是2'，3'， - 二脱氧-2'，3'-二脱氧-2'，3'-二脱氢核苷类似物 。 在某些优选的实施方案中，以所获得的立体异构体总量的约90％或更多的量获得优选的苯基硒封闭的内酯。 在甚至更优选的实施方案中，优选的立体异构体的量为所产生的苯基硒嵌段内酯的总量的至少95％，甚至更优选至少约97％。

公开(公告)号：US5478854A

公开(公告)日：1995-12-26

申请号：US212447

申请日：1994-03-10

申请人： Vittorio Farina ,  Shu-Hui Chen ,  David Langley ,  Mark D. Wittman ,  Joydeep Kant ,  Dolatrai M. Vyas

发明人： Vittorio Farina ,  Shu-Hui Chen ,  David Langley ,  Mark D. Wittman ,  Joydeep Kant ,  Dolatrai M. Vyas

IPC分类号： C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07F7/18 ,  C07F9/655 ,  C07F9/6558 ,  H01L21/48 ,  A61K31/33 ,  A61K31/34 ,  A61K31/38

CPC分类号： C07D407/12 ,  C07D305/14 ,  C07D409/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839

摘要： R.sup.g is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, phenyl, or heteroaryl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R.sup.2 is --OCOR, H, OH, --OR, --OSO.sub.2 R, --OCONR.sup.o R, --OCONHR, --OCOO(CH.sub.2).sub.t R, or --OCOOR; andR and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

摘要翻译： 其中R 1是-COR z，其中R z是RO-或R; R 8为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或W-Rx基团，W为键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，苯基或杂芳基，此外Rx可任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R2是-OCOR，H，OH，-OR，-OSO2R，-OCONRoR，-OCONHR，-OCOO（CH2）tR或-OCOOR; 并且R和R 4独立地是C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF3组。 本发明进一步提供了用于制备式I的脱氧紫杉醇的药物制剂和中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。

公开(公告)号：US5350866A

公开(公告)日：1994-09-27

申请号：US949449

申请日：1992-09-22

申请人： Robert A. Holton ,  Shu-Hui Chen ,  Vittorio Farina

发明人： Robert A. Holton ,  Shu-Hui Chen ,  Vittorio Farina

IPC分类号： C07C227/22 ,  C07C231/12 ,  C07C233/87 ,  C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07F7/18

CPC分类号： C07D407/12 ,  C07C227/22 ,  C07C231/12 ,  C07C233/87 ,  C07D305/14 ,  C07D409/12 ,  C07F7/1856 ,  C07F7/186 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2103/62

摘要： The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R.sub.10 is alkoxy, alkyl, alkenyl, alkynl, or aryl.

摘要翻译： 本发明涉及可用作抗肿瘤剂的10-脱乙酰氧基紫杉醇及其衍生物。 这些化合物具有式“IMAGE”，其中R 2是氢，羟基或被保护的羟基; R3和R4独立地是氢，羟基，被保护的羟基，甲基，-SH，-NH2或-NR8R9; R5为R10或-OR10; R6和R7独立地是氢，烷基或芳基; R8和R9独立地是氢，烷基，烯基，炔基或芳基; 和R 10是烷氧基，烷基，烯基，炔烃或芳基。

公开(公告)号：US20130263704A1

公开(公告)日：2013-10-10

申请号：US13441005

申请日：2012-04-06

申请人： Shu-Hui CHEN

发明人： Shu-Hui CHEN

IPC分类号： B25B13/48

CPC分类号： B25B27/00 ,  B25B27/0035 ,  F16D65/0043 ,  Y10T29/53683

摘要： A wheel cylinder adjuster includes plural actuating discs able to match different-sized wheel cylinders, and a driving wrench able to be jointed with the actuating disc. The driving wrench has two ends of its shank respectively provided with right-handed threads and left-handed threads on the surface, having a crosswise insert hole respectively bored at an outer side of the right-handed threads and of the left-handed threads, and the shank has two ends respectively protruding outward to form a positioning rod to be inserted in the insert hole of the actuating disc. Two positioning sleeves are respectively combined with the right-handed threads and the left-handed threads at the two ends of the shank. A holding rod is inserted in either one of the two insert holes at two ends of the driving wrench, and a positioning stop plate is provided to fix one of the two positioning sleeves.

摘要翻译： 轮缸调节器包括能够匹配不同大小的轮缸的多个致动盘，以及能够与致动盘连接的驱动扳手。 驱动扳手具有其柄部的两端，分别在表面上设有右旋螺纹和左旋螺纹，具有分别在右旋螺纹和左旋螺纹的外侧钻孔的横向插入孔， 并且柄部具有分别向外突出的两个端部，以形成插入致动盘的插入孔中的定位杆。 两个定位套筒分别与柄部两端的右旋螺纹和左旋螺纹结合。 把持杆插入驱动扳手的两端的两个插入孔的任一个中，并且设置有定位挡板来固定两个定位套筒中的一个。

公开(公告)号：US07670686B2

公开(公告)日：2010-03-02

申请号：US11436664

申请日：2006-05-19

申请人： Shu-Hui Chen ,  Makamba Honest ,  Ya-Yu Hsieh ,  Wang-Chou Sung

发明人： Shu-Hui Chen ,  Makamba Honest ,  Ya-Yu Hsieh ,  Wang-Chou Sung

IPC分类号： B32B25/20

CPC分类号： C08J7/04 ,  B32B27/00 ,  B32B27/08 ,  B32B27/16 ,  B32B27/18 ,  B32B27/283 ,  B32B27/302 ,  B32B27/308 ,  B32B27/34 ,  B32B27/42 ,  B32B2250/24 ,  B32B2307/552 ,  B32B2307/554 ,  B32B2307/714 ,  B32B2307/7145 ,  B32B2307/728 ,  B32B2535/00 ,  C08J2383/04 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31906

摘要： The present invention relates to a hydrophilic surface structure of the non-hydrophilic substrate and the manufacturing method for using the same. The hydrophilic substrate surface structure is fabricated by forming an amphiphilic polymer layer, a cross-linked stacking layer, and a hydrophilic layer in sequence on the surface of a non-hydrophilic substrate. For example, the hydrophobic surface of poly(dimethylsiloxane) (PDMS) can be made from hydrophobic to hydrophilic and the hydrophilicity can be retained for a long period of time and resist protein adsorption. The hydrophilic thin films give long term stability to the PDMS surface by resisting hydrophobicity recovery, which is the major problem with PDMS. The disclosed method can further be used in the immobilization of protein and other molecules. This method can also be used for modifying other substrates which suffer problems of surface instability.

摘要翻译： 本发明涉及非亲水性基材的亲水性表面结构体及其制造方法。 通过在非亲水性基材的表面上依次形成两亲性聚合物层，交联层叠层和亲水层来制造亲水性基材表面结构。 例如，聚（二甲基硅氧烷）（PDMS）的疏水表面可以由疏水性制成亲水性，并且亲水性可以长时间保留并抵抗蛋白质吸附。 亲水薄膜通过抵抗疏水性恢复对PDMS表面产生长期稳定性，这是PDMS的主要问题。 所公开的方法可以进一步用于固定蛋白质和其他分子。 该方法也可以用于改变其它具有表面不稳定性问题的基板。