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公开(公告)号：US09528938B2
公开(公告)日：2016-12-27
申请号：US15049970
申请日：2016-02-22
申请人： LI-COR, Inc.
发明人： Han-Wei Wang
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6456 , G01N2021/1787 , G01N2021/6439 , G01N2201/06113 , G01N2201/12 , G02B21/367 , G06T7/0012 , G06T7/55 , G06T11/60 , G06T15/205 , G06T17/20 , G06T2207/10024 , G06T2207/10048 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , G06T2207/30096 , G06T2207/30196 , H04N5/2256 , H04N5/332 , H04N7/181
摘要： Biopsy imaging devices with an imaging stage configured to rotate and tilt a biological sample, as well as a method for using it, are described. The stage can use rotating bearings or extendible, telescoping arms. The device has a white light for taking normal pictures and a near-infrared laser light for causing a fluorescence-biomolecule probed sample to fluoresce for fluorescence images in a light-tight housing. A set of both types of pictures are taken from angles around, above, and below the biopsy sample with one or more cameras to generate a 3-D model in a computer of the biopsy with fluorescence markings. The 3-D model can then be rendered and viewed on a display by a surgeon to determine if sufficient margins were removed from the patient.
摘要翻译： 描述了具有被配置为旋转和倾斜生物样品的成像台的活组织检查成像装置，以及其使用方法。 舞台可以使用旋转轴承或可伸缩的伸缩臂。 该装置具有用于拍摄正常图像的白光和近红外激光，用于使荧光 - 生物分子探测的样品在无光外壳中的荧光图像发荧光。 使用一个或多个相机从活检样本周围，上方和下方的角度拍摄一组两种类型的图像，以在具有荧光标记的活检的计算机中产生3-D模型。 然后可以由外科医生在显示器上呈现和观看3-D模型，以确定是否从患者中移除了足够的边缘。
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公开(公告)号：US09482653B2
公开(公告)日：2016-11-01
申请号：US14542926
申请日：2014-11-17
申请人： LI-COR, Inc.
IPC分类号： G01N33/00 , A01G7/00 , G01F1/05 , G01N21/3504
CPC分类号： G01N33/0031 , A01G7/00 , G01F1/05 , G01N21/3504 , G01N33/004 , G01N33/0098 , G01N2021/3513
摘要： Active compensation designs to offset the impact of gas diffusion sources and sinks in a photosynthesis and transpiration measurement system are disclosed. A sensor head for use in a gas exchange analysis system includes an active, piezoelectric flow splitting device for splitting a flow between a sample chamber and bypass pathway. The active flow splitting device is controlled by feedback from a downstream flow meter. A continuous measurement system for rapidly and accurately surveying large numbers of samples is described.
摘要翻译： 公开了用于抵消气体扩散源和水槽在光合作用和蒸腾测量系统中的影响的主动补偿设计。 用于气体交换分析系统的传感器头包括用于分离样品室和旁路通路之间的流动的主动压电流分流装置。 主动分流装置由来自下游流量计的反馈控制。 描述了用于快速和准确地测量大量样品的连续测量系统。
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公开(公告)号：US20160266045A1
公开(公告)日：2016-09-15
申请号：US15068373
申请日：2016-03-11
申请人： LI-COR, Inc.
发明人： Ying Wang , Xinshe Xu , Nisha Padhye
CPC分类号： G01N21/78 , C12Q1/28 , G01N21/76 , G01N33/582
摘要： The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
摘要翻译： 本发明提供近红外荧光和/或显色制剂，方法，系统和试剂盒。 当将吖嗪与氧化剂和过氧化物酶接触时，吖嗪被转化成浑浊的吖嗪衍生物，它们都是明显的和荧光的。 本发明还提供了检测生物分子的高灵敏度方法，显示出比化学发光方法更好的灵敏度。 有利地，制剂和反应没有鲁米诺或鲁米诺衍生物。
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公开(公告)号：US20150374819A1
公开(公告)日：2015-12-31
申请号：US14728304
申请日：2015-06-02
申请人： LI-COR, INC.
发明人： Joy L. Kovar
摘要： The present invention relates to compositions and methods for destroying target cells in a patient using photodynamic therapy. In particular, the present invention provides a photosensitizing agent based on a small molecular weight (
摘要翻译： 本发明涉及使用光动力学治疗来破坏患者中靶细胞的组合物和方法。 特别地，本发明提供了一种基于小分子量（<50kDa）蛋白质或肽或与酞菁染料缀合的小分子如700DX的光敏剂。
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公开(公告)号：US09194742B2
公开(公告)日：2015-11-24
申请号：US13667995
申请日：2012-11-02
申请人： LI-COR, INC.
CPC分类号： G01J3/26 , G01J3/021 , G01J3/42 , G01N21/3504 , G01N21/39 , G01N2021/399
摘要： Cavity enhanced absorption spectroscopy systems and methods for detecting trace gases using a resonance optical cavity, which contains a gas mixture to be analyzed, and a laser coupled to the cavity by optical feedback. The cavity has any of a variety of configurations with two or more mirrors, including for example a linear cavity, a v-shaped cavity and a ring optical cavity. The cavity will have multiple cavity resonant modes, or a comb of frequencies spaced apart, as determined by the parameters of the cavity, including the length of the cavity, as is well known. Systems and methods herein also allow for optimization of the cavity modes excited during a scan and/or the repetition rate.
摘要翻译： 使用包含要分析的气体混合物的共振光腔检测痕量气体的腔增强吸收光谱系统和方法，以及通过光学反馈耦合到腔的激光。 空腔具有两种或更多种反射镜的各种结构中的任何一种，包括例如线性腔，V形空腔和环形光腔。 空腔将具有多个空腔谐振模式，或者由空腔的参数确定的频率间隔开的梳子，包括空腔的长度，如众所周知的那样。 这里的系统和方法还允许优化在扫描期间激发的腔模式和/或重复率。
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26.发明申请SYSTEMS AND METHODS FOR CONTROLLING THE OPTICAL PATH LENGTH BETWEEN A LASER AND AN OPTICAL CAVITY 有权用于控制激光和光学腔之间的光学路径长度的系统和方法公开(公告)号：US20150103353A1
公开(公告)日：2015-04-16
申请号：US14052618
申请日：2013-10-11
申请人： LI-COR, Inc.
发明人： Serguei Koulikov
IPC分类号： G01J3/45
CPC分类号： G01J3/027 , G01J3/42 , G01J3/45 , G01N21/41 , G01N2021/391 , G01N2021/399
摘要： Systems and methods for controlling the optical path length between a feedback enabled laser and a cavity, and hence the optical feedback phase. A phasor element, positioned along an optical path between the laser and the cavity coupling mirror, includes a gas medium within a volume defined by the phasor element. The phasor element is configured to adjust or control an optical path length of the laser light between the laser and the cavity coupling mirror by adjusting or controlling a density of the gas medium within the phasor volume.
摘要翻译： 用于控制反馈使能的激光器和空腔之间的光程长度的系统和方法，并因此控制光学反馈阶段。 沿着激光器和腔耦合镜之间的光路定位的相量元件包括由相量元件限定的体积内的气体介质。 相量元件被配置为通过调节或控制相量体积内的气体介质的密度来调节或控制激光和腔耦合反射镜之间的激光的光路长度。
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公开(公告)号：US20150090000A1
公开(公告)日：2015-04-02
申请号：US14039686
申请日：2013-09-27
申请人： LI-COR, Inc.
IPC分类号： G01N33/00
CPC分类号： G01N33/0075 , H04J3/0644 , H04J3/0658 , H04J3/0667 , H04L12/403
摘要： Systems and methods for measuring gas flux are disclosed. One method for calculating gas flux includes: receiving a master clock signal from a global positioning system (GPS) module; transmitting a clock synchronization signal that is based on the master clock signal to a measurement subsystem configured to measure environmental data, wherein the measurement subsystem comprises at least two clocks; receiving the environmental data from the measurement subsystem, wherein the environmental data is associated with the at least two clocks; and calculating gas flux based on the environmental data received from the measurement subsystem.
摘要翻译： 公开了用于测量气体通量的系统和方法。 用于计算气体通量的一种方法包括：从全球定位系统（GPS）模块接收主时钟信号; 将基于所述主时钟信号的时钟同步信号发送到被配置为测量环境数据的测量子系统，其中所述测量子系统包括至少两个时钟; 从所述测量子系统接收环境数据，其中所述环境数据与所述至少两个时钟相关联; 并根据从测量子系统接收的环境数据计算气体通量。
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公开(公告)号：US08885167B2
公开(公告)日：2014-11-11
申请号：US13668005
申请日：2012-11-02
申请人： Li-Cor, Inc.
CPC分类号： G01N21/39 , G01N21/17 , G01N33/0062 , G01N2201/06113 , H01S5/0028 , H01S5/0085 , H01S5/0656
摘要： Cavity enhanced absorption spectroscopy systems and methods for detecting trace gases using a resonance optical cavity, which contains a gas mixture to be analyzed, and a laser coupled to the cavity by optical feedback. The cavity has any of a variety of configurations with two or more mirrors, including for example a linear cavity, a v-shaped cavity and a ring optical cavity. The cavity will have multiple cavity resonant modes, or a comb of frequencies spaced apart, as determined by the parameters of the cavity, including the length of the cavity, as is well known. Systems and methods herein also allow for optimization of the cavity modes excited during a scan and/or the repetition rate.
摘要翻译： 使用包含要分析的气体混合物的共振光腔检测痕量气体的腔增强吸收光谱系统和方法，以及通过光学反馈耦合到腔的激光。 空腔具有两种或更多种反射镜的各种结构中的任何一种，包括例如线性腔，V形空腔和环形光腔。 空腔将具有多个空腔谐振模式，或者由空腔的参数确定的频率间隔开的梳子，包括空腔的长度，如众所周知的那样。 这里的系统和方法还允许优化在扫描期间激发的腔模式和/或重复率。
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公开(公告)号：US20140206568A1
公开(公告)日：2014-07-24
申请号：US14223672
申请日：2014-03-24
申请人： LI-COR, Inc.
发明人： Ahmed Bouzid , Chris Lesiak , Daniel W. Konz , David L. Franzen , William Biggs , Jon P. Anderson
IPC分类号： G01N21/76 , C12Q1/68 , G01N21/62 , G01N33/543
CPC分类号： C12Q1/6825 , G01J1/0403 , G01N21/62 , G01N21/6486 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/54373 , H04N1/1017 , H04N1/191 , H04N1/1933
摘要： Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.
摘要翻译： 公开了用于精确地成像化学发光和其它发光的系统，装置和方法。 一种紧凑的平板扫描器，具有不透光的外壳，一个或多个线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的检测棒，以及高工作数值孔径（NA）光学器件密切扫描 在一个方向上的样品上，然后是相反的方向。 将两个或更多遍之间的每个像素位置（x，y）的强度读数的平均值或其他组合平均在一起以便补偿随时间变化的发光。 可以使用片上像素分档和多个时钟频率来最大化基于CCD的扫描仪中的信噪比。
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公开(公告)号：US20030064400A1
公开(公告)日：2003-04-03
申请号：US10228729
申请日：2002-08-26
申请人： LI-COR, Inc.
发明人： John G.K. Williams
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： B01L3/502761 , B01L2200/0668 , C12Q1/6834 , C12Q2563/131
摘要： The present invention provides apparatus and methods for orientating a nucleic acid on a bead in a microchannel port. The microchannel system is designed to work with the transport and orientation characteristics of the bead to place the DNA into position for analysis. Preferably, orientation is achieved by a combination of flowcell architecture and energy fields.
摘要翻译： 本发明提供了用于将核酸定向在微通道端口中的珠粒上的装置和方法。 微通道系统设计用于处理珠粒的转运和取向特征，以将DNA置于适当位置进行分析。 优选地，取向通过流动池结构和能量场的组合来实现。
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