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公开(公告)号：US08512636B2
公开(公告)日：2013-08-20
申请号：US12152201
申请日：2008-05-12
申请人： Ross Blanton , Michael James Justin , James Clement Bishop , Jacky S. Yam , Robert J. Polster , Mark Joseph Fanning
发明人： Ross Blanton , Michael James Justin , James Clement Bishop , Jacky S. Yam , Robert J. Polster , Mark Joseph Fanning
IPC分类号： G01N31/00
CPC分类号： G01N35/00029 , G01N2035/00148 , G01N2035/0465 , Y10T436/115831 , Y10T436/12
摘要： An integrated instrument processes fluid test samples using disposable test devices. The test devices are carried in a carrier. The instrument includes a vacuum station receiving the carrier for batch loading of the test devices with fluid samples to be tested. The user removes the carrier from the vacuum station and inserts it into a loading station of a separate carrier and test device processing subsystem. This subsystem includes a transport system moving the carrier through the instrument where various modules perform operations on the test devices, including sealing the test devices, loading the test devices into an incubation station, incubation of the test devices, test device reading, and test device disposal.
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公开(公告)号：US07556770B2
公开(公告)日：2009-07-07
申请号：US12074998
申请日：2008-03-06
IPC分类号： G01N21/13
CPC分类号： G01N21/13 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , G01N2035/0491 , Y10T436/11 , Y10T436/113332
摘要： A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
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公开(公告)号：US07510681B2
公开(公告)日：2009-03-31
申请号：US10695550
申请日：2003-10-28
IPC分类号： G01N21/13
CPC分类号： G01N21/13 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , G01N2035/0491 , Y10T436/11 , Y10T436/113332
摘要： A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
摘要翻译： 为样品测试机提供运输系统。 运输系统包括一个承载一组测试样品装置的托架和用于使载体移动通过样品测试机的驱动子系统。 驱动子系统包括一个往复运动的马达驱动的块，其与载体相接合，并以沿着纵向轴线从入口站到样品测试机中的多个处理站的预定纵向路径来回移动载体。 当载体沿着路径移动时，处理站被访问。 载体包括通过策略放置的光中断传感器检测到的槽形式的特征。 当载体移动时，通过传感器检测槽，从而在载体和测试装置移动通过仪器时连续跟踪载体和测试装置的位置。
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公开(公告)号：US20080175756A1
公开(公告)日：2008-07-24
申请号：US12074998
申请日：2008-03-06
IPC分类号： G01N35/10
CPC分类号： G01N21/13 , G01N35/00029 , G01N2035/00148 , G01N2035/0465 , G01N2035/0491 , Y10T436/11 , Y10T436/113332
摘要： A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.
摘要翻译： 为样品测试机提供运输系统。 运输系统包括一个承载一组测试样品装置的托架和用于使载体移动通过样品测试机的驱动子系统。 驱动子系统包括一个往复运动的马达驱动的块，其与载体相接合，并以沿着纵向轴线从入口站到样品测试机中的多个处理站的预定纵向路径来回移动载体。 当载体沿着路径移动时，处理站被访问。 载体包括通过策略放置的光中断传感器检测到的槽形式的特征。 当载体移动时，通过传感器检测槽，从而在载体和测试装置移动通过仪器时连续跟踪载体和测试装置的位置。
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公开(公告)号：USD437797S1
公开(公告)日：2001-02-20
申请号：US29123901
申请日：2000-05-25
申请人： James Clement Bishop
设计人： James Clement Bishop
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26.发明授权Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use 失效用于扩增反应的双室一次性反应容器，其反应处理站及其使用方法
公开(公告)号：US5786182A
公开(公告)日：1998-07-28
申请号：US850207
申请日：1997-05-02
申请人： Luigi Catanzariti , Bryan W. Kluttz , Geoff A. McKinley , Arthur L. Garland , Louis Graziano , James G. Moe , Marcela Vera-Garcia , James Clement Bishop , David Chastain , Fabio Gennari
发明人： Luigi Catanzariti , Bryan W. Kluttz , Geoff A. McKinley , Arthur L. Garland , Louis Graziano , James G. Moe , Marcela Vera-Garcia , James Clement Bishop , David Chastain , Fabio Gennari
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/026 , B01L2300/0825 , B01L2300/0861 , B01L2400/049 , B01L2400/0655
摘要： A reaction vessel for a nucleic acid amplification reaction has a first chamber containing an amplification reagent mix, a second chamber containing an amplification enzyme, and a fluid channel or chamber connecting the first and second chambers together. A fluid sample is introduced into the first chamber. After a denaturation and primer annealing process has occurred in the first chamber, the fluid channel is opened to allow the solution of the reagent and fluid sample to flow into the second chamber. The second chamber is maintained at an optimal temperature for the amplification reaction. A station is described for processing test strips incorporating the reaction vessels. The station includes temperature and vacuum control subsystems to maintain proper temperatures in the reaction vessel and effectuate the transfer of the fluid from one chamber to the other in an automated fashion without human intervention.
摘要翻译： 用于核酸扩增反应的反应容器具有包含扩增试剂混合物的第一室，含有扩增酶的第二室和将第一和第二室连接在一起的流体通道或室。 将流体样品引入第一室。 在第一室中发生变性和引物退火过程之后，打开流体通道以允许试剂和流体样品的溶液流入第二室。 第二个室保持在扩增反应的最佳温度。 描述了一个工位，用于处理加入反应容器的试片。 该站包括温度和真空控制子系统，以在反应容器中保持适当的温度，并且以无需人为干预的方式实现流体从一个室到另一个室的转移。
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