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292 条记录 (耗时 0.029 秒)

    Silicon carbide fiber reinforced silicon carbide composite material
    22.
    发明授权
    Silicon carbide fiber reinforced silicon carbide composite material 有权

    公开(公告)号：US11142483B2

    公开(公告)日：2021-10-12

    申请号：US15534236

    申请日：2015-12-11

    申请人： Kyoto University

    发明人： Tatsuya Hinoki ,  Kazuya Shimoda

    IPC分类号： C04B35/80 ,  C04B35/565 ,  C04B35/628 ,  B32B18/00 ,  C04B35/573

    摘要： The present invention provides a silicon carbide fiber reinforced silicon carbide composite material, which is a composite material of SiC fibers and SiC ceramics with improved toughness and can be produced with high yield by relatively simple steps without complex steps such as a step of oxidation-resistant coating or an advanced interface control step. The silicon carbide composite material comprises a multiphase matrix and silicon carbide fibers disposed in the matrix, the matrix containing a silicon carbide phase and a phase that includes a substance of low reactivity with respect to silicon carbide. It can be obtained by steps suitable for mass production and ensures greatly improved fracture toughness while maintaining the excellent properties of SiC ceramics.

    Chimeric antigen receptors that bind to SSEA4 and uses thereof
    25.
    发明授权
    Chimeric antigen receptors that bind to SSEA4 and uses thereof 有权

    公开(公告)号：US10751399B2

    公开(公告)日：2020-08-25

    申请号：US15926382

    申请日：2018-03-20

    申请人： CHO Pharma USA, Inc.

    发明人： Lan Bo Chen

    IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K16/18 ,  C07K14/725 ,  C07K14/71 ,  A61P35/00

    摘要： An isolated nucleic acid that contains a nucleotide sequence that encodes the polypeptide of SEQ ID NO: 3. The polypeptide of SEQ ID NO: 3 specifically binds to stage-specific embryonic antigen 4 (SSEA4). Also disclosed is a recombinant cell comprising the isolated nucleic acid described above, a viral vector containing the above isolated nucleic acid, and an isolated polypeptide including the sequence of SEQ ID NO: 3. Provided as well is a chimeric antigen receptor (CAR) that includes a single chain Fv having the sequence of SEQ ID NO: 3 and specifically binding to SSEA4. Moreover, a method is disclosed for treating a tumor by transducing in vitro the T cells of a subject having a tumor expressing SSEA4 with a vector that encodes the CAR, expanding the transduced T cells, and infusing the expanded transduced T cells into the subject, whereby an anti-tumor T cell response is raised.

    Method for treating or enhancing muscle tissue
    28.
    发明授权
    Method for treating or enhancing muscle tissue 有权

    公开(公告)号：US10265365B2

    公开(公告)日：2019-04-23

    申请号：US15126870

    申请日：2015-03-19

    申请人： Stellenbosch University

    发明人： Barbara Huisamen ,  Cindy George

    IPC分类号： A61K36/48

    摘要： The use of plant material from the Prosopis glandulosa tree (commonly known as Honey mesquite) is described for aiding sporting ability, and in particular for preventing and/or treating muscle injury and enhancing muscle strength. The plant material is typically the dried and ground pods from the tree, but could also be from other parts of the tree, such as the leaves, bark or roots.

    Light therapy device
    29.
    发明授权
    Light therapy device 有权

    公开(公告)号：US10213616B1

    公开(公告)日：2019-02-26

    申请号：US14509358

    申请日：2014-10-08

    申请人： Sun LifeLight, Inc.

    发明人： Gary D. Grimard ,  Alison C. Todd

    IPC分类号： A61N5/06

    摘要： A light therapy device is provided that emits both blue spectrum wavelength light and cyan spectrum wavelength light stimulate intrinsically photosensitive Retinal Ganglion Cell (ipRGC) receptors located in a human eye. The light therapy device may be attached or secured in an area of or directly to a consumer device, such as a computer, or laptop, etc., so that a user operating the consumer device may utilize the consumer device and the light therapy device at the same time. Further, settings of the light therapy device may be controlled utilizing an application that may be executing on a computing device.