知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

806 条记录 (耗时 0.052 秒)

    Compounds for treating prostate cancer
    12.
    发明授权
    Compounds for treating prostate cancer 有权

    公开(公告)号：US10882834B2

    公开(公告)日：2021-01-05

    申请号：US15023349

    申请日：2014-09-18

    申请人： University of Pittsburgh—of the Commonwealth System of Higher Education

    发明人： Peter Wipf ,  Erin M. Skoda ,  Zhou Wang

    IPC分类号： A61K31/495 ,  C07D295/185 ,  C07D295/192 ,  A61K45/06 ,  C07D295/26 ,  C07D213/70 ,  C07D333/16 ,  C07D261/08 ,  C07D317/54 ,  C07D413/12 ,  A61K31/4525 ,  A61K31/551 ,  A61K31/58 ,  A61K31/496

    摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R20—(Z)b—(Y)c—(R21)a—X—R22—R23 wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(=0)- or —S(=0)(=0)-; R22 is a moiety that includes at least one divalent amino radical; R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; a is 0 or 1; b is 0 or 1; and c is 0 or 1; provided that if X is —C(=0)- then Y is not S.