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11.发明授权Transformant for enhancing bioethanol production, and method for producing ethanol by using said strain 有权用于增强生物乙醇生产的转化体，以及使用所述菌株生产乙醇的方法公开(公告)号：US08772000B2
公开(公告)日：2014-07-08
申请号：US13641946
申请日：2011-04-15
申请人： Sung Ok Han , Kyung Ok Yu , Seung Wook Kim
发明人： Sung Ok Han , Kyung Ok Yu , Seung Wook Kim
CPC分类号： C12N15/81 , C07K14/39 , C07K14/395 , C12N9/0006 , C12N9/1085 , C12N9/1205 , C12N9/88 , C12P7/06 , C12Y101/01001 , C12Y101/01006 , C12Y101/05003 , C12Y205/0101 , C12Y207/01027 , C12Y207/01029 , C12Y401/01001 , Y02E50/17
摘要： The present invention relates to a transformant for inhibiting glycerol production through deletion of glycerol producing genes of Saccharomyces cerevisiae modified so as to use glycerol as a fermentation source, or enhancing bioethanol production through overexpression of TATA-binding proteins, SPT3 and SPT15, and a method for producing ethanol by using the transformant.
摘要翻译： 本发明涉及通过缺失酿酒酵母的甘油产生基因来修饰甘油作为发酵源，或通过TATA结合蛋白SPT3和SPT15的过表达增强生物乙醇生产来抑制甘油产生的转化体，以及方法 用于通过使用转化体生产乙醇。
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公开(公告)号：US08455239B2
公开(公告)日：2013-06-04
申请号：US12820505
申请日：2010-06-22
申请人： Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano , Peter Meinhold , Aristos Aristidou , Catherine Asleson Dundon , Christopher Smith
发明人： Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano , Peter Meinhold , Aristos Aristidou , Catherine Asleson Dundon , Christopher Smith
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/88 , C12N9/90 , C12N15/81 , C12Y101/01001 , C12Y101/01008 , C12Y101/01086 , C12Y101/05003 , C12Y202/01006 , C12Y401/01001 , C12Y401/01074 , C12Y402/01009 , Y02E50/10
摘要： The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译： 本发明提供包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可以包含导致丙酮酸脱羧酶和/或甘油-3-磷酸脱氢酶活性降低的修饰。 在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。
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公开(公告)号：US09944954B2
公开(公告)日：2018-04-17
申请号：US15228770
申请日：2016-08-04
发明人： Ritu Bhalla , Gopal K. Chotani , Michael Dauner , Mark J. Nelson , Daniel P. O'Keefe , Caroline M. Peres , Jahnavi Chandra Prasad , Jean-Francois Tomb
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N15/52 , C12Y101/01008 , C12Y101/01094 , C12Y101/05003 , C12Y102/01012 , Y02E50/10 , Y02P20/52
摘要： Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.
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公开(公告)号：US20140234923A1
公开(公告)日：2014-08-21
申请号：US14233830
申请日：2011-07-22
申请人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
发明人： R. Rogers Yocum , Theron Hermann , Xiaohui Hu
CPC分类号： C12P7/46 , C07K14/245 , C12N1/20 , C12N9/0006 , C12N9/1205 , C12N15/52 , C12P7/56 , C12Y101/01008 , C12Y101/05003
摘要： The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.
摘要翻译： 本发明是通过使用甘油作为碳源的生物发酵来生产有机酸和其它有用的化学品的领域。 描述了能够以高产率和高纯度将甘油转化成有机有机酸的新型微生物和发酵方法。
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公开(公告)号：US20130252298A1
公开(公告)日：2013-09-26
申请号：US13907394
申请日：2013-05-31
申请人： GEVO, INC.
发明人： Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano , Peter Meinhold , Aristos Aristidou , Catherine Asleson Dundon , Christopher Smith
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/88 , C12N9/90 , C12N15/81 , C12Y101/01001 , C12Y101/01008 , C12Y101/01086 , C12Y101/05003 , C12Y202/01006 , C12Y401/01001 , C12Y401/01074 , C12Y402/01009 , Y02E50/10
摘要： The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
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公开(公告)号：US20120295319A1
公开(公告)日：2012-11-22
申请号：US12740295
申请日：2008-10-29
CPC分类号： C12P7/06 , C12N9/0006 , C12Y101/01008 , C12Y101/05003 , Y02E50/17
摘要： The invention relates to a method of modifying a yeast cell for the production of ethanol. According to the invention, the activity of the Gpd1 protein and/or the Gpd2 protein is reduced.
摘要翻译： 本发明涉及一种修饰用于生产乙醇的酵母细胞的方法。 根据本发明，Gpd1蛋白和/或Gpd2蛋白的活性降低。
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17.发明申请Process for Producing Fermentation Product from Carbon Sources Containing Glycerol using Corynebacteria 有权使用棒杆菌从含有甘油的碳源生产发酵产物的方法公开(公告)号：US20100129884A1
公开(公告)日：2010-05-27
申请号：US12522304
申请日：2008-01-22
申请人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
发明人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
CPC分类号： C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
摘要： The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
摘要翻译： 本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。 更具体地说，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并累积工业上有用的氨基，从含有甘油或一部分甘油的甘油或一部分甘油产生发酵产物的方法 培养基中的酸。
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公开(公告)号：US09994877B2
公开(公告)日：2018-06-12
申请号：US15153492
申请日：2016-05-12
发明人： Soonchun Chung , Jinha Kim , Kwangmyung Cho
CPC分类号： C12P7/42 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N15/52 , C12N15/81 , C12P7/56 , C12Y101/01001 , C12Y101/01008 , C12Y101/01027 , C12Y101/01028 , C12Y101/01094 , C12Y101/02003 , C12Y101/02004 , C12Y101/05003 , C12Y102/01004 , C12Y102/0101 , C12Y401/01001
摘要： Provided are a genetically engineered yeast cell having increased activity of SUL1, STR3, HXT7, ERR1, GRX8, MXR1, GRE1, MRK1, AAD10 or a combination thereof, compared to a parent cell, and also having acid tolerance, a method of preparing the same, and a method of producing lactate using the same.
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公开(公告)号：US09441250B2
公开(公告)日：2016-09-13
申请号：US14208474
申请日：2014-03-13
发明人： Ritu Bhalla , Gopal K Chotani , Michael Dauner , Mark J Nelson , Daniel P O'Keefe , Caroline M Peres , Jahnavi Chandra Prasad , Jean-Francois Tomb
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N15/52 , C12Y101/01008 , C12Y101/01094 , C12Y101/05003 , C12Y102/01012 , Y02E50/10 , Y02P20/52
摘要： Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.
摘要翻译： 本文提供了对NADH和GPD酶具有增加的KM的甘油-3-磷酸脱氢酶（GPD）酶，对NADH和NADPH具有基本上相同的亲和力和/或被甘油-3-磷酸抑制的反馈。 本文还提供了包含编码GPD的异源基因和编码GPD的内源基因中的缺失或破坏的重组微生物。 还提供了包含编码GPD的异源基因和丁醇生物合成途径的重组微生物。 还提供了生产丁醇的方法，包括提供本文所述的重组微生物，并且在产生丁醇的条件下使重组微生物与至少一种可发酵碳底物接触。
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公开(公告)号：US20160153009A1
公开(公告)日：2016-06-02
申请号：US14856308
申请日：2015-09-16
申请人： DANISCO US INC.
CPC分类号： C12P7/06 , C12N9/0006 , C12Y101/01008 , C12Y101/05003 , Y02E50/17
摘要： The invention relates to a method of modifying a yeast cell for the production of ethanol. According to some embodiments of the invention, the activity of the Gpd1 protein and/or the Gpd2 protein is reduced.
摘要翻译： 本发明涉及一种修饰用于生产乙醇的酵母细胞的方法。 根据本发明的一些实施方案，Gpd1蛋白和/或Gpd2蛋白的活性降低。
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