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    Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol
    1.
    发明申请
    Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol 审中-公开
    用于生产异丁醇的胞质异丁醇途径定位

    公开(公告)号：US20140308721A1

    公开(公告)日：2014-10-16

    申请号：US14157799

    申请日：2014-01-17

    申请人： Gevo, Inc.

    发明人： Jun Urano ,  Catherine Asleson Dundon ,  Peter Meinhold ,  Reid M. Renny Feldman ,  Aristos A. Aristidou ,  Andrew Hawkins ,  Thomas Buelter ,  Matthew Peters ,  Doug Lies ,  Stephanie Porter-Scheinman ,  Christopher Smith ,  Ruth Berry ,  Ishmeet Kalra

    IPC分类号： C12N15/81 ,  C12P7/16

    CPC分类号： C12N15/81 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/88 ,  C12P7/16 ,  Y02E50/10

    摘要： The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

    摘要翻译： 本发明提供重组微生物，其包含产生异丁醇的代谢途径与位于细胞溶质中的至少一种异丁醇途径酶，其中所述重组微生物被选择以从碳源产生异丁醇。 还提供了使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可以包含胞质活性异丁醇途径酶。 在一些实施方案中，本发明提供具有胞质活性的突变，修饰和/或嵌合异丁醇途径酶。 在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。

    YEAST MICROORGANISMS WITH REDUCED 2,3-BUTANEDIOL ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS
    4.
    发明申请
    YEAST MICROORGANISMS WITH REDUCED 2,3-BUTANEDIOL ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开
    YEAST微生物与减少的2,3-丁二醇积累用于改进燃料，化学和氨基酸的生产

    公开(公告)号：US20140080188A1

    公开(公告)日：2014-03-20

    申请号：US14003534

    申请日：2012-03-09

    申请人： GEVO, Inc.

    发明人： Christopher Smith ,  Thomas Buelter ,  Peter Meinhold ,  Aristos Aristidou ,  Stephanie Porter-Scheinman

    IPC分类号： C12P7/16 ,  C12N15/81

    CPC分类号： C12N15/81 ,  C12N15/52 ,  C12P7/16 ,  C12P7/18 ,  C12P7/26 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y101/01303 ,  Y02E50/10

    摘要： The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of an acetolactate-derived by-product such as 2,3-butanediol. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

    摘要翻译： 本发明涉及包含生物合成途径的重组微生物和使用所述重组微生物产生各种有益代谢物的方法。 在本发明的各个方面，重组微生物可以进一步包含一种或多种修饰，导致还原或消除乙酰乳酸衍生的副产物如2,3-丁二醇。 在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。