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公开(公告)号：US08669078B2
公开(公告)日：2014-03-11
申请号：US12097104
申请日：2006-12-14
申请人： Jae-Gu Pan , Heung-Chae Jung , Eui-Joong Kim , Han-Seung Lee , Young Hoon Park , Hyoung Suk Kim , Jong-Kwon Han , Jin Nam Lee , Ki-Hoon Oh , Jeong Hwan Kim , Yoon-Suk Oh , Jae Ick Sim , Kuk-Ki Hong , Kyung Oh Choi , Hyun Soo Kim , Min-Ji Baek , Tae Sun Kang
发明人： Jae-Gu Pan , Heung-Chae Jung , Eui-Joong Kim , Han-Seung Lee , Young Hoon Park , Hyoung Suk Kim , Jong-Kwon Han , Jin Nam Lee , Ki-Hoon Oh , Jeong Hwan Kim , Yoon-Suk Oh , Jae Ick Sim , Kuk-Ki Hong , Kyung Oh Choi , Hyun Soo Kim , Min-Ji Baek , Tae Sun Kang
摘要： Disclosed herein are ammonia-specific 5′-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5′-XMP aminase. The resulting 5′-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5′-XMP into 5′-GMP. Thus, the ammonia-specific 5′-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5′-XMP into 5′-GMP.
摘要翻译： 本文公开了氨特异性5'-XMP氨基酶突变体及其制备方法。 在5'-XMP氨基酶中引入谷氨酰胺依赖性催化活性位点的突变。 所得到的5'-XMP氨基酶突变体缺乏谷氨酰胺依赖性活性，并特异性地与外部氨反应将5'-XMP转化为5'-GMP。 因此，与野生型相比，氨特异性5'-XMP氨基酶突变体在细胞内更稳定，可用于将5'-XMP工业转化为5'-GMP。
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公开(公告)号：US20080318278A1
公开(公告)日：2008-12-25
申请号：US12097104
申请日：2006-12-14
申请人： Jae-Gu Pan , Heung-Chae Jung , Eui-Joong Kim , Han-Seung Lee , Young Hoon Park , Hyoung Suk Kim , Jong-Kwon Han , Jin Nam Lee , Ki-Hoon Oh , Jeong Hwan Kim , Yoon-Suk Oh , Jae Ick Sim , Kuk-Ki Hong , Kyung Oh Choi , Hyun Soo Kim , Min-Ji Baek , Tae Sun Kang
发明人： Jae-Gu Pan , Heung-Chae Jung , Eui-Joong Kim , Han-Seung Lee , Young Hoon Park , Hyoung Suk Kim , Jong-Kwon Han , Jin Nam Lee , Ki-Hoon Oh , Jeong Hwan Kim , Yoon-Suk Oh , Jae Ick Sim , Kuk-Ki Hong , Kyung Oh Choi , Hyun Soo Kim , Min-Ji Baek , Tae Sun Kang
摘要： Disclosed herein are ammonia-specific 5′-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5′-XMP aminase. The resulting 5′-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5′-XMP into 5′-GMP. Thus, the ammonia-specific 5′-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5′-XMP into 5′-GMP.
摘要翻译： 本文公开了氨特异性5'-XMP氨基酶突变体及其制备方法。 在5'-XMP氨基酶中引入谷氨酰胺依赖性催化活性位点的突变。 所得到的5'-XMP氨基酶突变体缺乏谷氨酰胺依赖性活性，并特异性地与外部氨反应将5'-XMP转化为5'-GMP。 因此，与野生型相比，氨特异性5'-XMP氨基酶突变体在细胞内更稳定，可用于将5'-XMP工业转化为5'-GMP。
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3.发明申请Microorganism Producing L-Methionine Precursor And Method Of Producing L-Methionine And Organic Acid From The L-Methionine Precursor 有权生产L-甲硫氨酸前体的微生物和L-甲硫氨酸前体产生L-甲硫氨酸和有机酸的方法公开(公告)号：US20100184164A1
公开(公告)日：2010-07-22
申请号：US12066111
申请日：2007-07-30
申请人： So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
发明人： So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
CPC分类号： C12P13/12 , C07C323/58 , C12N9/1029 , C12N9/1085 , C12P7/46 , C12P13/06
摘要： The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine precursor as a substrate, and microorganism strains used in each step.
摘要翻译： 本发明涉及L-甲硫氨酸和有机酸的制造方法，其特征在于，包括以下工序：工序1）制备生产L-甲硫氨酸前体的菌株，通过菌株的发酵生产L-甲硫氨酸前体; 步骤2）通过与L-甲硫氨酸前体作为底物的酶反应方法生产L-甲硫氨酸和有机酸，以及每个步骤中使用的微生物菌株。
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4.发明申请Process for Producing Fermentation Product from Carbon Sources Containing Glycerol using Corynebacteria 有权使用棒杆菌从含有甘油的碳源生产发酵产物的方法公开(公告)号：US20100129884A1
公开(公告)日：2010-05-27
申请号：US12522304
申请日：2008-01-22
申请人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
发明人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
CPC分类号： C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
摘要： The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
摘要翻译： 本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。 更具体地说，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并累积工业上有用的氨基，从含有甘油或一部分甘油的甘油或一部分甘油产生发酵产物的方法 培养基中的酸。
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5.发明申请Escherichia Strain Capable of Converting Xmp to Gmp and Maintaining the Inactivated State of Gene(s) Associated with Gmp Degradation and Methods of Using the Same 有权能够将Xmp转化为Gmp并维持与Gmp降解有关的基因失活状态的大肠杆菌菌株及其使用方法公开(公告)号：US20080299620A1
公开(公告)日：2008-12-04
申请号：US11814417
申请日：2006-01-20
申请人： Young-hoon Park , Hyoung-suk Kim , Jin-nam Lee , Ki-hoon Oh , Jeong-hwan Kim , Yoon-suk Oh , Jae-ick Sim , Kyung-oh Choi
发明人： Young-hoon Park , Hyoung-suk Kim , Jin-nam Lee , Ki-hoon Oh , Jeong-hwan Kim , Yoon-suk Oh , Jae-ick Sim , Kyung-oh Choi
CPC分类号： C12N9/16 , C12N9/1077 , C12P19/32 , C12R1/19
摘要： Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same.
摘要翻译： 提供源自大肠杆菌属的突变菌株。 具有deoD，aphA，appA和hprt基因的累积失活的GPU1114（登录号KCCM-10536）及其使用方法。
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6.发明授权Microorganism producing L-methionine precursor and method of producing L-methionine and organic acid from the L-methionine precursor 有权生产L-甲硫氨酸前体的微生物和L-甲硫氨酸前体产生L-甲硫氨酸和有机酸的方法公开(公告)号：US08426171B2
公开(公告)日：2013-04-23
申请号：US12066111
申请日：2007-07-30
申请人： So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
发明人： So-young Kim , Kwang-myung Cho , Yong-uk Shin , Hye-won Um , Kyung-oh Choi , Jin-sook Chang , Young-wook Cho , Young-hoon Park
CPC分类号： C12P13/12 , C07C323/58 , C12N9/1029 , C12N9/1085 , C12P7/46 , C12P13/06
摘要： The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine precursor as a substrate, and microorganism strains used in each step.
摘要翻译： 本发明涉及L-甲硫氨酸和有机酸的制造方法，其特征在于，包括以下工序：工序1）制备生产L-甲硫氨酸前体的菌株，通过菌株的发酵生产L-甲硫氨酸前体; 步骤2）通过与L-甲硫氨酸前体作为底物的酶反应方法生产L-甲硫氨酸和有机酸，以及每个步骤中使用的微生物菌株。
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7.发明授权Process for producing fermentation product from carbon sources containing glycerol using Corynebacteria 有权使用棒杆菌从含有甘油的碳源生产发酵产物的方法公开(公告)号：US08426165B2
公开(公告)日：2013-04-23
申请号：US12522304
申请日：2008-01-22
申请人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
发明人： Kwang-myung Cho , Kyung-oh Choi , Hyun-ae Bae
IPC分类号： C12N15/00
CPC分类号： C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
摘要： The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
摘要翻译： 本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。 更具体地说，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并累积工业上有用的氨基，从含有甘油或一部分甘油的甘油或一部分甘油产生发酵产物的方法 培养基中的酸。
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8.发明授权Escherichia strain capable of converting XMP to GMP and maintaining the inactivated state of gene(s) associated with GMP degradation and methods of using the same 有权能够将XMP转化为GMP并保持与GMP降解相关的基因的失活状态的大肠杆菌菌株及其使用方法公开(公告)号：US07741101B2
公开(公告)日：2010-06-22
申请号：US11814417
申请日：2006-01-20
申请人： Young-hoon Park , Hyoung-suk Kim , Jin-nam Lee , Ko-hoon Oh , Jeong-hwan Kim , Yoon-suk Oh , Jae-ick Sim , Kyung-oh Choi
发明人： Young-hoon Park , Hyoung-suk Kim , Jin-nam Lee , Ko-hoon Oh , Jeong-hwan Kim , Yoon-suk Oh , Jae-ick Sim , Kyung-oh Choi
CPC分类号： C12N9/16 , C12N9/1077 , C12P19/32 , C12R1/19
摘要： Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same.
摘要翻译： 提供源自大肠杆菌属的突变菌株。 具有deoD，aphA，appA和hprt基因的累积失活的GPU1114（登录号KCCM-10536）及其使用方法。
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