公开(公告)号：US20180255289A1

公开(公告)日：2018-09-06

申请号：US15973750

申请日：2018-05-08

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： Rafael Piestun

IPC: H04N13/204 ,  H04N13/254

CPC classification number: H04N13/204 ,  G06T2200/04 ,  H04N5/23212 ,  H04N13/254

Abstract: Imaging systems and imaging methods are disclosed to estimate a three-dimensional position of an object at a scene and/or generate a three-dimensional image of the scene. The imaging system may include, for example, one or many light sources; an optical system configured to direct light from the one or more light sources into a pattern onto the scene; a mask; a detector array disposed to receive light from the scene through the mask; and at least one processor communicatively coupled with the detector and configured to estimate a depth of a particle within the scene.

公开(公告)号：US10036735B2

公开(公告)日：2018-07-31

申请号：US14913958

申请日：2014-08-26

Applicant: The Regents of The University of Colorado, A Body Corporate

Inventor： Rafael Piestun ,  Hengyi Ju ,  Jacob Dove ,  Antonio Miguel Caravaca-Aguirre ,  Todd Murray ,  Donald Conkey

IPC: G01N29/44 ,  G01N21/00 ,  G01N29/24 ,  A61B5/00 ,  G01N21/17 ,  G01N29/06

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  G01N21/1702 ,  G01N29/0654 ,  G01N2021/1706 ,  G01N2201/0675

Abstract: Systems and methods are disclosed to enhance three-dimensional photoacoustic imaging behind, through, or inside a scattering material. Some embodiments can increase the optical fluence in an ultrasound transducer focus and/or enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium can serve as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, the object can be scanned in two dimensions and/or a spot can be scanned by re-optimizing the wavefront before post-processing of the data to reconstruct the image. The temporal photoacoustic signal provides information to reconstruct the third-dimensional information.

公开(公告)号：US20160231553A1

公开(公告)日：2016-08-11

申请号：US15018684

申请日：2016-02-08

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Wyatt Mohrman ,  Ginni Grover

IPC: G02B21/36 ,  G02B21/06

CPC classification number: G02B21/367 ,  G02B21/12 ,  G02B21/244 ,  G02B21/245

Abstract: Some embodiments of the invention include a system comprising a positioning device configured to a hold a sample and adjust a position of a sample in response to receiving a drift compensation signal; a first light source disposed to transilluminate the sample; a second light source disposed to epi-illuminate the sample; an optical system configured to receive light from the sample and generate a three-dimensional point spread function from the light from the sample; an image sensor disposed relative to the optical system that produces an image from the light collected from the sample via the optical system; and logic electrically coupled with the image detector and the positioning device, the logic configured to determine one or more drift compensation values from images imaged by the image detector, and configured to send one or more drift compensation signals to the positioning device.

Abstract translation: 本发明的一些实施例包括一种包括定位装置的系统，该定位装置被配置为保持样本并响应于接收漂移补偿信号而调整样本的位置; 设置成透过样品的第一光源; 第二光源，被设置为表面照射样品; 光学系统，被配置为从所述样品接收光，并从所述样品的光产生三维点扩散函数; 相对于所述光学系统设置的图像传感器，其从通过所述光学系统从所述样本收集的光产生图像; 以及与图像检测器和定位装置电耦合的逻辑，该逻辑被配置为从由图像检测器成像的图像中确定一个或多个漂移补偿值，并且被配置为向定位装置发送一个或多个漂移补偿信号。

公开(公告)号：US20240134179A1

公开(公告)日：2024-04-25

申请号：US18546996

申请日：2022-02-18

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Sakshi Singh ,  Simon Labouesse

IPC: G02B21/16 ,  A61B5/00 ,  G02B23/24 ,  G02B23/26

CPC classification number: G02B21/16 ,  A61B5/0068 ,  A61B5/0071 ,  G02B23/2469 ,  G02B23/26

Abstract: Technology is disclosed herein that enhances imaging, sensing, and property detection of objects. In an implementation, a wave radiation source transmits waves through a complex medium towards an object. The complex medium may be engineered or naturally occurring. Wave modulators modulate the waves transmitted through the complex medium. The wave modulators may comprise spatial or temporal modulators. Secondary waves propagate back though the complex medium in response interaction between the waves and the object. Detectors detect wave properties from the secondary waves. A digital processor reconstructs data based on the secondary wave properties.

公开(公告)号：US20210080484A1

公开(公告)日：2021-03-18

申请号：US17105475

申请日：2020-11-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Simon Labouesse ,  Markus B. Raschke ,  Eric Muller ,  Samuel Johnson

IPC: G01Q60/22 ,  G01Q60/06 ,  G01Q10/06 ,  G01Q30/04 ,  G01J3/44 ,  G01J3/45 ,  G01J3/10 ,  G01J3/02 ,  G01J3/28

Abstract: Infrared (IR) vibrational scattering scanning near-field optical microscopy (s-SNOM) has advanced to become a powerful nanoimaging and spectroscopy technique with applications ranging from biological to quantum materials. However, full spatiospectral s-SNOM continues to be challenged by long measurement times and drift during the acquisition of large associated datasets. Various embodiments provide for a novel approach of computational spatiospectral s-SNOM by transforming the basis from the stationary frame into the rotating frame of the IR carrier frequency. Some embodiments see acceleration of IR s-SNOM data collection by a factor of 10 or more in combination with prior knowledge of the electronic or vibrational resonances to be probed, the IR source excitation spectrum, and other general sample characteristics.

公开(公告)号：US10514586B2

公开(公告)日：2019-12-24

申请号：US16039156

申请日：2018-07-18

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Omer Tzang ,  Rafael Piestun ,  Antonio Miguel Caravaca-Aguirre ,  Kelvin Wagner

IPC: G02F1/365 ,  G02F1/35

Abstract: Recent remarkable progress in wave-front shaping has enabled control of light propagation inside linear media to focus and image through scattering objects. In particular, light propagation in multimode fibers comprises complex intermodal interactions and rich spatiotemporal dynamics. Control of physical phenomena in multimode fibers and its applications is in its infancy, opening opportunities to take advantage of complex mode interactions. Various embodiments of the present technology provide wave-front shaping for controlling nonlinear phenomena in multimode fibers. Using a spatial light modulator at the fiber's input and a genetic algorithm optimization, some embodiments control a highly nonlinear stimulated Raman scattering cascade and its interplay with four wave mixing via a flexible implicit control on the superposition of modes that are coupled into the fiber.

公开(公告)号：US09967541B2

公开(公告)日：2018-05-08

申请号：US14934031

申请日：2015-11-05

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun

IPC: H04N13/00 ,  H04N13/02

CPC classification number: H04N13/204 ,  G06T2200/04 ,  H04N5/23212 ,  H04N13/254

Abstract: Imaging systems and imaging methods are disclosed to estimate a three-dimensional position of an object at a scene and/or generate a three-dimensional image of the scene. The imaging system may include, for example, one or many light sources; an optical system configured to direct light from the one or more light sources into a pattern onto the scene; a mask; a detector array disposed to receive light from the scene through the mask; and at least one processor communicatively coupled with the detector and configured to estimate a depth of a particle within the scene.

公开(公告)号：US09538157B2

公开(公告)日：2017-01-03

申请号：US14465543

申请日：2014-08-21

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Sean Albert Quirin

IPC: G06K9/00 ,  H04N13/02 ,  G06T7/00

CPC classification number: H04N13/204 ,  G06T7/77 ,  G06T2207/10056 ,  G06T2207/10064

Abstract: Embodiments include methods, systems, and/or devices that may be used to image, obtain three-dimensional information from a scene, and/or locate multiple small particles and/or objects in three dimensions. A point spread function (PSF) with a predefined three dimensional shape may be implemented to obtain high Fisher information in 3D. The PSF may be generated via a phase mask, an amplitude mask, a hologram, or a diffractive optical element. The small particles may be imaged using the 3D PSF. The images may be used to find the precise location of the object using an estimation algorithm such as maximum likelihood estimation (MLE), expectation maximization, or Bayesian methods, for example. Calibration measurements can be used to improve the theoretical model of the optical system. Fiduciary particles/targets can also be used to compensate for drift and other type of movement of the sample relative to the detector.

Abstract translation: 实施例包括可以用于图像，从场景获取三维信息和/或定位三维中的多个小粒子和/或对象的方法，系统和/或设备。 可以实现具有预定三维形状的点扩散函数（PSF）以获得3D中的高Fisher信息。 PSF可以通过相位掩模，幅度掩模，全息图或衍射光学元件生成。 可以使用3D PSF对小颗粒进行成像。 例如，图像可以用于使用诸如最大似然估计（MLE），期望最大化或贝叶斯方法的估计算法来找到对象的精确位置。 校准测量可用于改善光学系统的理论模型。 受信颗粒/目标也可用于补偿样品相对于检测器的漂移和其他类型的运动。

公开(公告)号：US09509956B2

公开(公告)日：2016-11-29

申请号：US13670954

申请日：2012-11-07

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Donald Conkey

IPC: H04N7/18 ,  G02B26/06 ,  G01N21/47

CPC classification number: H04N7/18 ,  G01N21/4795 ,  G02B26/06

Abstract: A wavefront is optimized imaging a sample. A binary off-axis hologram is encoded by selective adoption of states for each mirror of a deformable mirror device, which is illuminated with an incident beam of light. A single diffraction order that has encoded phase-mask information is selected from light reflected from the deformable mirror device and focused onto the sample. Light scattered from the sample is directed to a photodetector. A transmission matrix through the sample is calculated from light received by the photodetector.

Abstract translation: 波前优化成像样本。 通过选择性地采用用入射光束照射的可变形反射镜装置的每个反射镜的状态来编码二进制离轴全息图。 已经编码相位掩模信息的单个衍射顺序是从可变形反射镜装置反射的光中选出并聚焦到样品上。 从样品散射的光被引导到光电检测器。 通过光电检测器接收的光计算通过样品的透射矩阵。

公开(公告)号：US11994533B2

公开(公告)日：2024-05-28

申请号：US17105475

申请日：2020-11-25

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Rafael Piestun ,  Simon Labouesse ,  Markus B. Raschke ,  Eric Muller ,  Samuel Johnson

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/44 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06 ,  G01Q60/22

CPC classification number: G01Q60/22 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/2846 ,  G01J3/4412 ,  G01J3/45 ,  G01Q10/06 ,  G01Q30/04 ,  G01Q60/06

Abstract: Infrared (IR) vibrational scattering scanning near-field optical microscopy (s-SNOM) has advanced to become a powerful nanoimaging and spectroscopy technique with applications ranging from biological to quantum materials. However, full spatiospectral s-SNOM continues to be challenged by long measurement times and drift during the acquisition of large associated datasets. Various embodiments provide for a novel approach of computational spatiospectral s-SNOM by transforming the basis from the stationary frame into the rotating frame of the IR carrier frequency. Some embodiments see acceleration of IR s-SNOM data collection by a factor of 10 or more in combination with prior knowledge of the electronic or vibrational resonances to be probed, the IR source excitation spectrum, and other general sample characteristics.