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公开(公告)号：US07923055B2
公开(公告)日：2011-04-12
申请号：US11550069
申请日：2006-10-17
IPC分类号： A61L33/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： A method of manufacturing a drug delivery system uses gas cluster ion beam irradiation on an outer surface of a member to determine one or more characteristics of the drug delivery system.
摘要翻译： 制备药物递送系统的方法使用气体团簇离子束照射在构件的外表面上以确定药物递送系统的一个或多个特征。
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公开(公告)号：US20160114083A1
公开(公告)日：2016-04-28
申请号：US14985825
申请日：2015-12-31
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
摘要翻译： 在一个实施方案中，药物递送系统和方法提供包括药物和聚合物或其它材料的组合的构件，以及通过气体团离子束照射外部表面的外部表面形成在构件的外表面中的包封层 该成员，该封装层适于确定药物递送系统的一个或多个特征。
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公开(公告)号：US20120321707A1
公开(公告)日：2012-12-20
申请号：US13596236
申请日：2012-08-28
IPC分类号： A61K9/52
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
摘要翻译： 在一个实施方案中，药物递送系统和方法提供包括药物物质和聚合物或其他材料的组合的构件，以及通过气体团离子束照射外壳的外表面形成在构件的外表面中的封装层 该成员，该封装层适于确定药物递送系统的一个或多个特征。
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14.发明授权Method of manufacturing a drug delivery system using gas cluster ion beam irradiation 有权使用气体簇离子束照射制造药物递送系统的方法公开(公告)号：US09226998B2
公开(公告)日：2016-01-05
申请号：US13596236
申请日：2012-08-28
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： A method for producing a drug delivery system provides a member including a combination of a drug substance and a polymer or other material; and forms a layer on a surface of the combination using gas cluster ion beam irradiation, which layer determines a release rate for the drug substance, wherein the layer is an encapsulating layer formed by densifying or carbonizing components of the drug or of the polymer or of the other material by the gas cluster ion beam irradiation.
摘要翻译： 制备药物递送系统的方法提供包括药物和聚合物或其它材料的组合的成员; 并且使用气体簇离子束照射在组合物的表面上形成层，该层确定药物的释放速率，其中该层是通过使药物或聚合物的组分致密化或碳化而形成的包封层，或者是 其他材料通过气体簇离子束照射。
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公开(公告)号：US08252418B2
公开(公告)日：2012-08-28
申请号：US13041525
申请日：2011-03-07
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
摘要翻译： 在一个实施方案中，药物递送系统和方法提供包括药物和聚合物或其它材料的组合的构件，以及通过气体团离子束照射外部表面的外部表面形成在构件的外表面中的包封层 该成员，该封装层适于确定药物递送系统的一个或多个特征。
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公开(公告)号：US20110160845A1
公开(公告)日：2011-06-30
申请号：US13041525
申请日：2011-03-07
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
摘要： In one embodiment, a drug delivery system and method provide a member including a combination of a drug substance and a polymer or other material, and an encapsulating layer formed in an outer surface of the member by gas cluster ion beam irradiation of the outer surface of the member, which encapsulating layer is adapted to determine one or more characteristics of the drug delivery system.
摘要翻译： 在一个实施方案中，药物递送系统和方法提供包括药物物质和聚合物或其他材料的组合的构件，以及通过气体团离子束照射外壳的外表面形成在构件的外表面中的封装层 该成员，该封装层适于确定药物递送系统的一个或多个特征。
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公开(公告)号：US08187662B2
公开(公告)日：2012-05-29
申请号：US12643047
申请日：2009-12-21
申请人： Stephen M. Blinn , Barry M. Zide
发明人： Stephen M. Blinn , Barry M. Zide
CPC分类号： C23C14/022 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61L31/14 , A61L31/16 , A61L2300/00 , B05D1/02 , B05D3/0493 , B05D3/06 , C23C14/221 , C23C14/24 , C23C14/505 , C23C14/5833
摘要： A method of controlling the drug release rate of a drug coated endovascular stent by depositing a drug material layer on the stent and then modifying the drug material using gas cluster ion beam irradiation to create a carbon matrix with interstices containing the original drug. The rate at which the drug elutes through the interstices can be controlled by processing parameters. Multiple layers may be employed to create time varying release rates.
摘要翻译： 一种通过在支架上沉积药物材料层，然后使用气体簇离子束照射来改变药物材料来控制药物包被的血管内支架的药物释放速率的方法，以产生含有原始药物的间隙的碳基质。 药物通过间隙洗脱的速率可以通过加工参数来控制。 可以采用多层来产生时变释放速率。
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18.发明授权Methods of adhering drugs to the surface of medical devices through ion beam surface modification 有权通过离子束表面改性将药物粘附到医疗器械表面的方法公开(公告)号：US07105199B2
公开(公告)日：2006-09-12
申请号：US10144919
申请日：2002-05-13
CPC分类号： C23C14/022 , A61F2/86 , A61L31/14 , A61L31/16 , A61L2300/00 , C23C14/221 , C23C14/505
摘要： Methods of implanting, applying, or adhering various drug molecules directly into or onto the surface of medical devices through gas cluster ion beam (GCIB) and/or monomer ion beam surface modification of the medical devices before or after depositing the various drug molecules onto the medical devices.
摘要翻译： 在将各种药物分子沉积到所述药物分子之前或之后，通过气体团簇离子束（GCIB）和/或医疗装置的单体离子束表面改性将各种药物分子直接注入，施加或粘附到医疗装置的表面或其上的方法 医疗设备。
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公开(公告)号：US20100098833A1
公开(公告)日：2010-04-22
申请号：US12643047
申请日：2009-12-21
申请人： Stephen M. Blinn , Barry M. Zide
发明人： Stephen M. Blinn , Barry M. Zide
IPC分类号： B05D3/06
CPC分类号： C23C14/022 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61L31/14 , A61L31/16 , A61L2300/00 , B05D1/02 , B05D3/0493 , B05D3/06 , C23C14/221 , C23C14/24 , C23C14/505 , C23C14/5833
摘要： A method of controlling the drug release rate of a drug coated endovascular stent by depositing a drug material layer on the stent and then modifying the drug material using gas cluster ion beam irradiation to create a carbon matrix with interstices containing the original drug. The rate at which the drug elutes through the interstices can be controlled by processing parameters. Multiple layers may be employed to create time varying release rates.
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公开(公告)号：US07666462B2
公开(公告)日：2010-02-23
申请号：US11349483
申请日：2006-02-07
申请人： Stephen M. Blinn , Barry M. Zide
发明人： Stephen M. Blinn , Barry M. Zide
CPC分类号： C23C14/022 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61L31/14 , A61L31/16 , A61L2300/00 , B05D1/02 , B05D3/0493 , B05D3/06 , C23C14/221 , C23C14/24 , C23C14/505 , C23C14/5833
摘要： A method of controlling the drug release rate of a drug coated endovascular stent by depositing a drug material layer on the stent and then modifying the drug material using gas cluster ion beam irradiation to create a carbon matrix with interstices containing the original drug. The rate at which the drug elutes through the interstices can be controlled by processing parameters. Multiple layers may be employed to create time varying release rates.
摘要翻译： 一种通过在支架上沉积药物材料层，然后使用气体簇离子束照射来改变药物材料来控制药物包被的血管内支架的药物释放速率的方法，以产生含有原始药物的间隙的碳基质。 药物通过间隙洗脱的速率可以通过加工参数来控制。 可以采用多层来产生时变释放速率。
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