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13 条记录 (耗时 0.02 秒)

    Nucleotides for prevention and treatment of bacterial and fungal pathologies
    12.
    发明申请
    Nucleotides for prevention and treatment of bacterial and fungal pathologies 有权
    用于预防和治疗细菌和真菌病理学的核苷酸

    公开(公告)号：US20070020635A1

    公开(公告)日：2007-01-25

    申请号：US10574254

    申请日：2004-06-03

    申请人： Yin Chen ,  Xin Tan

    发明人： Yin Chen ,  Xin Tan

    IPC分类号： C12Q1/68 ,  C40B40/02 ,  C40B40/08 ,  C07H21/04 ,  A61K48/00 ,  C12N15/74

    CPC分类号： C12N15/113 ,  C07H21/04 ,  C12N15/1034 ,  C12N15/111 ,  C12N15/74 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/127 ,  C12N2320/11 ,  C12N2330/31 ,  C12Q1/6837 ,  C12Q2565/531

    摘要： A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping cell growth, killing bacteria or fungi, or preventing bacteria and/or fungi from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic agents for, for instance, providing a method for treatment of bacterial infections such as sepsis.

    摘要翻译： 选择性诱导型单链DNA（ssDNA）表达文库，构建ssDNA表达文库的方法，使用表达文库筛选ssDNA的方法以及鉴定改变细菌和真菌基因表达的ssDNA分子的方法 ）与细胞生长和毒素生成和分泌有关。 除了别的以外，筛选文库用于鉴别有效阻止细胞生长，杀死细菌或真菌，或阻止细菌和/或真菌合成和分泌其毒素的ODN，和/或发现在真核生物中有效的ODN（例如， 哺乳动物）细胞用于靶向改变基因功能。 该文库也可用于鉴定用作治疗剂的ssDNA或ODN，例如提供治疗细菌感染如败血症的方法。

    Oligodoxynucleotide (ODN) libraries, their use in screening for antibacterial agents, and catalytic ODN sequence for use as an antibacterial agent
    13.
    发明申请
    Oligodoxynucleotide (ODN) libraries, their use in screening for antibacterial agents, and catalytic ODN sequence for use as an antibacterial agent 审中-公开
    寡核苷酸（ODN）文库，它们在抗菌剂筛选中的应用，以及用作抗菌剂的催化ODN序列

    公开(公告)号：US20050136393A1

    公开(公告)日：2005-06-23

    申请号：US10743956

    申请日：2003-12-23

    申请人： Yin Chen ,  Xin Tan

    发明人： Yin Chen ,  Xin Tan

    IPC分类号： C12N9/22 ,  C12N15/85 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： C12Q1/18

    摘要： A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping bacterial growth, killing bacteria or preventing bacteria from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic antibacterial reagents, for identifying essential bacterial genes that can serve as targets for antibiotic discovery, and for providing a method for treatment of bacterial infections.

    摘要翻译： 选择性诱导型单链DNA（ssDNA）表达文库，构建ssDNA表达文库的方法，使用表达文库筛选ssDNA的方法以及鉴定改变细菌基因表达的ssDNA分子的方法 细胞生长和毒素生成和分泌。 除了别的以外，筛选文库用于鉴别有效阻止细菌生长，杀死细菌或防止细菌合成和分泌其毒素的ODN，和/或发现在真核（例如哺乳动物）细胞中有效的ODN，用于靶向改变 基因功能。 该文库还可用于鉴定用作治疗性抗菌试剂的ssDNA或ODN，用于鉴定可用作抗生素发现靶标的重要细菌基因，以及提供治疗细菌感染的方法。