公开(公告)号：US07985196B2

公开(公告)日：2011-07-26

申请号：US12086593

申请日：2007-03-06

Applicant: Pascal Kopperschmidt ,  Joachim Noack

Inventor： Pascal Kopperschmidt ,  Joachim Noack

IPC: A61M37/00 ,  C02F1/44

CPC classification number: A61M1/3643 ,  A61M1/1682 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652

Abstract: A method and a hemodialysis machine provide for at least partial emptying of an extracorporeal blood circulation after patient blood in the circulation has been returned to the patient via an infusion liquid which displaces the blood. The method includes emptying at least a blood chamber of a hemodialyzer subdivided by a semipermeable membrane into the blood chamber and a dialysis fluid chamber without additionally connecting an arterial blood line and a venous blood line of the circulation to one another. The arterial blood line is actively or passively aerated at a first point and the venous blood line is actively or passively aerated at a second point. The infusion liquid is emptied through the membrane into the dialysis fluid chamber and then via a dialysis fluid discharge line. The method is operable by a control program that runs automatically without requiring any manual input after activation of the program.

Abstract translation: 一种方法和血液透析机在循环中的患者血液已经通过置换血液的输注液体返回给患者之后，至少部分排空体外血液循环。 所述方法包括将至少由半透膜细分的血液透析器的血液室排空到血液室中，以及透析液室，而不将动脉血管和循环的静脉血液线彼此连接。 动脉血液线在第一点被主动地或被动地通气，并且静脉血液线在第二点被主动或被动地充气。 将输液通过膜排空到透析液室中，然后通过透析液排出管。 该方法可通过自动运行的控制程序进行操作，而不需要在激活程序之后进行任何手动输入。

公开(公告)号：US20100204633A1

公开(公告)日：2010-08-12

申请号：US12733702

申请日：2008-08-26

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M1/14 ,  G06F15/00 ,  G08B21/00

CPC classification number: A61M1/342 ,  A61M1/3639 ,  A61M1/3672 ,  A61M5/1452 ,  A61M5/16859 ,  A61M2205/14 ,  A61M2205/3331

Abstract: The present invention relates to a method for checking and/or monitoring the correct operation of an adding device of a medical apparatus, wherein the medical apparatus includes an extracorporeal circuit with which the adding device is connected such that an agent can be introduced into the extracorporeal circuit by means of the adding device, the pressure loss in the extracorporeal circuit being measured and evaluated for checking and/or monitoring the correct operation of the adding device. In accordance with the invention, the adding device for this purpose generates an oscillating pressure course.

Abstract translation: 本发明涉及一种用于检查和/或监视医疗装置的添加装置的正确操作的方法，其中所述医疗装置包括与所述添加装置连接的体外电路，使得可以将药剂引入体外 通过加法装置对体外循环中的压力损失进行测量和评估，以检查和/或监视加法装置的正确操作。 根据本发明，用于该目的的添加装置产生振荡压力进程。

公开(公告)号：US09724455B2

公开(公告)日：2017-08-08

申请号：US13599028

申请日：2012-08-30

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/1615 ,  A61M1/36 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/50

Abstract: Method and apparatus for controlling the dialysate flow in a dialysis device. A change of the value of a control factor, caused by a variation of a property of the dialysate or of the blood or by a change of the dialysate flow, is determined in order to control the dialysate flow. The control factor is a measure for the exchange of substances via the dialyzer and thus the effectiveness of the dialyzer. If the change of the value of the control factor exceeds a limit, the dialysate flow is increased. On the other hand, the dialysate flow is reduced if the change of the value of the control factor falls short of the limit range.

公开(公告)号：US20110230812A1

公开(公告)日：2011-09-22

申请号：US13130116

申请日：2009-11-14

Applicant: Pascal Kopperschmidt ,  Gross Malte ,  Spickermann Reiner

Inventor： Pascal Kopperschmidt ,  Gross Malte ,  Spickermann Reiner

IPC: A61M37/00 ,  A61B5/02

CPC classification number: A61B5/02042 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/18 ,  A61M2205/3331

Abstract: A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line, particularly paravasal bleeding during extra-corporeal blood treatment, such as for hemodialysis, hemofiltration or hemodiafiltration is provided. A device for extra-corporeal blood treatment, particularly for hemodialysis, hemofiltration or hemodiafiltration, comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extra-corporeal blood treatment. If paravasal bleeding occurs during the blood treatment, the positive dynamic pressure on the line leading to the vascular access rises on the venous cannula during the extra-corporeal blood treatment, or the suction pressure on the line leaving the vascular access, such as the arterial cannula during extra-corporeal blood treatment, rises; that is, the suction pressure becomes more negative. The pressure rise begins moderately at first and then becomes increasingly greater. Decisive for the method and the device, therefore, is that pressure changes that come from a pressure level exhibiting a large difference from the reference value find stronger consideration than those that come from a pressure level that exhibits only a minor difference from the reference value.

Abstract translation: 一种方法和装置，用于在通过管线向血管通路供血时和/或通过管线从血管通路中取出血液，特别是在体外血液处理期间特别是paravasal出血，例如 用于血液透析，提供血液滤过或血液透析滤过。 还提供了一种用于体外血液处理的装置，特别是用于血液透析，血液滤过或血液透析滤过的装置，其包括用于识别旁路出血的装置。 该方法和装置基于在体外血液处理期间记录的动脉分支中的动脉压的变化或在体外循环的静脉分支中的静脉压。 如果在血液治疗期间发生paravasal渗血，则导致血管通路的线上的积极动态压力在体外血液处理期间在静脉插管上升，或者离开血管通路的线路上的吸入压力，例如动脉 套管在体外血液治疗中升高; 也就是说，吸入压力变得更负。 首先压力上升开始适度，然后变得越来越大。 因此，对于该方法和装置来说，与来自与参考值显示较大差异的压力水平的压力变化比从与参考值仅显示微小差异的压力水平的压力变化相比更强烈地考虑。

公开(公告)号：US20090306574A1

公开(公告)日：2009-12-10

申请号：US12282568

申请日：2006-12-08

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M39/12

CPC classification number: A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/1418 ,  A61M2205/18 ,  Y10T24/3439 ,  Y10T24/44 ,  Y10T24/44538 ,  Y10T403/22

Abstract: The invention relates to a device and to a method for monitoring access to vessels during extracorporeal blood treatment. The invention forms a loop in the arterial and/or venous line and provides device for fixing a section of the line in a loop. When the line is stressed under tension, the loop contracts and the line finally kinks. The modification of the diameter of the line and the formation of a kink in the line leads to a rise of pressure in the line, which is monitored by a pressure monitoring device. If the pressure exceeds a predetermined threshold value, the aspirating cannula is in danger of slipping out of the vessel access or has partially or completely slipped out, thus allowing the threshold value to be determined for alarms.

Abstract translation: 本发明涉及在体外血液处理期间监测血管通路的装置和方法。 本发明在动脉和/或静脉线中形成环，并提供用于将线的一部分固定在环中的装置。 当线路受到紧张的压力时，环路收缩，线路终于扭结。 线的直径的改变和线中的扭结的形成导致管线中的压力升高，这由压力监测装置监测。 如果压力超过预定的阈值，则抽吸插管有可能从容器进入或从部分或全部滑出，从而允许为报警确定阈值。

公开(公告)号：US09452252B2

公开(公告)日：2016-09-27

申请号：US12933466

申请日：2009-03-24

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M1/14 ,  A61B5/021 ,  A61M1/36

CPC classification number: A61M1/3656 ,  A61M1/3639 ,  A61M1/3653 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/52

Abstract: The invention relates to a method and a device for monitoring a vascular access during an extracorporeal blood treatment. The method and the device according to the invention are based on the monitoring of the difference between the venous pressure measured by a venous pressure sensor and the arterial pressure measured by an arterial pressure sensor (in the extracorporeal blood circuit. According to the method and the device according to the invention, a test function describing disturbances in the extracorporeal blood circuit is determined. Said test function is used to determine a noise-free differential pressure from the measured venous and arterial pressure, said differential pressure being evaluated in an arithmetic and evaluation unit to identify a defective vascular access.

Abstract translation: 本发明涉及用于在体外血液处理期间监测血管通路的方法和装置。 根据本发明的方法和装置是基于监测由静脉压力传感器测量的静脉压与由动脉压传感器测量的动脉压之间的差异（在体外血液回路中），根据该方法和 根据本发明的装置，确定描述体外血液循环中的紊乱的测试功能，所述测试功能用于根据测得的静脉和动脉压来确定无噪音压差，所述差压在算术和评估中进行评估 识别血管通路有缺陷的单位。

公开(公告)号：US08747663B2

公开(公告)日：2014-06-10

申请号：US11128088

申请日：2005-05-11

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: B01D21/24 ,  B01D24/38

CPC classification number: A61M1/342 ,  A61B5/02141 ,  A61B5/7225 ,  A61B5/7257 ,  A61M1/1601 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  A61M2205/3355 ,  A61M2205/702 ,  A61M2230/30

Abstract: The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyser or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyser or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyser or filter. In addition, the invention relates to an extracorporeal blood treatment device with a facility for detecting predilution or postdilution, which device operates according to the processes detailed above.

Abstract translation: 本发明涉及一种用于监测布置在体外血流中的透析器或过滤器上游或下游的置换液的供给的方法。 一个实施方案提供了用于检测预稀释或后稀释用于测量透析器或过滤器下游的血流中的压力，根据在关闭和/或启动后的压力变化来识别预稀释或后稀释 提供用于输送替代流体的替代泵。 另一个实施例提供了基于归因于替代泵的振荡压力信号与特征参考信号的比较来识别预稀释或后稀释。 比较替代泵的压力信号的特征参考信号优选是布置在用于输送透析器或过滤器上游的血液的血液中的血液泵的振荡压力信号。 此外，本发明涉及具有检测预稀释或后稀释的设备的体外血液处理装置，该装置根据上述方法进行操作。

公开(公告)号：US20120318739A1

公开(公告)日：2012-12-20

申请号：US13512133

申请日：2010-11-16

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: A61M1/16 ,  B01D61/32

CPC classification number: A61M1/342 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3635 ,  A61M2205/3334 ,  B01D61/243 ,  B01D61/28 ,  B01D61/32 ,  B01D2311/14 ,  B01D2311/16

Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

Abstract translation: 本发明涉及一种用体外血液处理装置调节供体取代物的方法，所述体外血液处理装置包括由半透膜分隔成血液室的透析器和透析液室以及用于供给取代基的装置。 此外，本发明涉及具有用于调节供体的装置的体外血液处理装置。 对体外血液治疗中取代基的供应调节作为透析器流变负荷的函数。 为了调节体外血液处理中取代基的供应，透析器的流变学载量由透析器上的跨膜压力和透析器的流动阻力确定，并且根据负载增加或降低取代率。 因此，不再需要选择透析器参数或血液参数，并且预稀释和稀释后的区别也被淘汰。

公开(公告)号：US20100168640A1

公开(公告)日：2010-07-01

申请号：US12086593

申请日：2007-03-06

Applicant: Pascal Kopperschmidt ,  Joachim Noack

Inventor： Pascal Kopperschmidt ,  Joachim Noack

IPC: A61M1/16

CPC classification number: A61M1/3643 ,  A61M1/1682 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652

Abstract: The invention relates to a method and a hemodialysis machine for at least partial emptying of an extracorporeal blood circulation after the blood of a patient in the extracorporeal blood circulation has been returned to the patient with the help of an infusion liquid which displaces the blood and after the patient has been separated from the extracorporeal blood circulation. The object of the invention is to empty at least the blood chamber of a hemodialyzer (1) that is subdivided by a semipermeable membrane (2) into a blood chamber (3) and a dialysis fluid chamber (4) without additionally connecting the arterial blood line (5) and the venous blood line (7) of the extracorporeal blood circulation to one another. To do so, the arterial blood line (5) is actively or passively aerated at a first point (50) and/or the venous blood line (7) is actively or passively aerated at a second point (40) and the liquid is emptied through the semipermeable membrane (2) into the dialysis fluid chamber (4) and a dialysis fluid discharge line (21) leaving this chamber. The inventive method can take place here through a control program that runs automatically in the control unit (30) of a hemodialysis machine without requiring special operating steps by the operating person after activation of the program.

Abstract translation: 本发明涉及一种方法和血液透析机，用于在体外血液循环中的患者的血液已经借助置换血液的输注液体返回给患者之后至少部分排空体外血液循环，并且之后 病人已经与体外血液循环分离。 本发明的目的是至少将由半透膜（2）细分的血液透析器（1）的血液室排空到血液室（3）和透析液室（4）中，而不需要额外连接动脉血 线（5）和体外血液循环的静脉血液线（7）。 为此，动脉血液管线（5）在第一点（50）处被主动地或被动地通气，和/或静脉血液管线（7）在第二点（40）被主动地或被动地充气并且液体被排空 通过半透膜（2）进入透析液室（4）和离开该室的透析液排出管（21）。 本发明的方法可以通过在血液透析机的控制单元（30）中自动运行的控制程序进行，而不需要操作者在程序激活之后的特殊操作步骤。

公开(公告)号：US20090152179A1

公开(公告)日：2009-06-18

申请号：US12085680

申请日：2006-07-14

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: B01D35/14 ,  B01D35/143

Abstract: This invention relates to a method for clearing a wetted hydrophobic filter, in which in a first step the air permeability of the hydrophobic filter is monitored and in which in a second step the hydrophobic filter is cleared by means of a connected air pump, if it is detected that the hydrophobic filter is clogged. Furthermore, the invention relates to an apparatus for performing this method.

Abstract translation: 本发明涉及一种清洗湿润疏水性过滤器的方法，其中在第一步骤中监测疏水性过滤器的透气性，并且在第二步骤中，通过连接的空气泵将疏水性过滤器清除，如果 检测到疏水性过滤器堵塞。 此外，本发明涉及一种用于执行该方法的装置。