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公开(公告)号：US20170146515A1
公开(公告)日：2017-05-25
申请号：US15425253
申请日：2017-02-06
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
IPC: G01N33/493 , C12Q1/04 , G01N35/04 , G01N21/03 , G01N35/02
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US09506866B2
公开(公告)日：2016-11-29
申请号：US13960387
申请日：2013-08-06
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
CPC classification number: G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US11073450B2
公开(公告)日：2021-07-27
申请号：US15955163
申请日：2018-04-17
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.
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14.发明申请公开(公告)号：US20210187417A1
公开(公告)日：2021-06-24
申请号：US17141322
申请日：2021-01-05
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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公开(公告)号：US20200240977A1
公开(公告)日：2020-07-30
申请号：US16842061
申请日：2020-04-07
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
IPC: G01N33/493 , C12Q1/04 , G01N21/03 , G01N35/02 , G01N35/04
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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Patent Agency Ranking
公开(公告)号：US10656140B2
公开(公告)日：2020-05-19
申请号：US15425253
申请日：2017-02-06
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US10130902B2
公开(公告)日：2018-11-20
申请号：US14560363
申请日：2014-12-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: B01D29/00 , B01D37/00 , B01L3/00 , C12Q1/24 , G01N1/40 , G01G17/06 , G01N33/493 , G01N33/49 , G01N5/02 , G01N15/00 , G01F15/12
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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公开(公告)号：US10018564B2
公开(公告)日：2018-07-10
申请号：US15060703
申请日：2016-03-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: G01N21/64 , C12Q1/04 , G01N33/483
CPC classification number: G01N21/6486 , C12Q1/04 , G01N33/4833 , G01N2021/6417 , G01N2201/062 , G01N2201/129
Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.
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19.发明申请公开(公告)号：US20170023480A1
公开(公告)日：2017-01-26
申请号：US15060703
申请日：2016-03-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: G01N21/64 , C12Q1/04 , G01N33/483
CPC classification number: G01N21/6486 , C12Q1/04 , G01N33/4833 , G01N2021/6417 , G01N2201/062 , G01N2201/129
Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.
Abstract translation: 本发明涉及允许从不含有该基因的类似分离物中分离含有特定抗生素抗性基因的常见细菌的分离物的方法。 更具体地，本发明涉及利用采用固有荧光，光学数据分析和人工智能方法来分析细菌菌株的多维光学特性的自动化快速平台系统的方法。
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公开(公告)号：US20150010993A1
公开(公告)日：2015-01-08
申请号：US14330450
申请日：2014-07-14
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico , John S. Laudo
IPC: G01N33/493 , G01N35/02 , G01N21/03
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
Abstract translation: 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于保持四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。
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