公开(公告)号：US20180186852A1

公开(公告)日：2018-07-05

申请号：US15898384

申请日：2018-02-16

申请人： Opko Biologics Ltd.

发明人： Fuad FARES ,  Udi Eyal Fima

IPC分类号： C07K14/555 ,  C07K14/61 ,  C07K14/505 ,  C07K14/59 ,  A61K47/64 ,  A61K38/19

CPC分类号： C07K14/555 ,  A61K38/19 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35 ,  C07K2319/91

摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

公开(公告)号：US20180050113A1

公开(公告)日：2018-02-22

申请号：US15801554

申请日：2017-11-02

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： A61K47/60 ,  A61K38/26 ,  A61K38/22

CPC分类号： A61K47/60 ,  A61K38/22 ,  A61K38/26

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US09663778B2

公开(公告)日：2017-05-30

申请号：US14274061

申请日：2014-05-09

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： C12N15/09 ,  C12N5/00 ,  C07K14/745 ,  C12N9/96 ,  C12N9/64 ,  C07K14/59 ,  C07K14/505 ,  A61K38/00

CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/31 ,  C12N9/6437 ,  C12N9/644

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US09458444B2

公开(公告)日：2016-10-04

申请号：US13759860

申请日：2013-02-05

申请人： Opko Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： C07K14/745 ,  C07K1/00 ,  A61K38/36 ,  C12N9/50 ,  C07K14/505 ,  C07K14/59 ,  C12N9/64

CPC分类号： C12N9/50 ,  A61K38/00 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/02 ,  C07K2319/31 ,  C07K2319/91 ,  C12N9/6437 ,  C12N9/644 ,  C12Y304/21021

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

摘要翻译： 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码该羧基末端肽的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。

公开(公告)号：US12029780B2

公开(公告)日：2024-07-09

申请号：US17549017

申请日：2021-12-13

申请人： OPKO BIOLOGICS LTD.

发明人： Fuad Fares ,  Udi Eyal Fima

IPC分类号： A61K38/27 ,  A61K38/24 ,  A61K47/00 ,  A61K47/02 ,  A61K47/12 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K19/00 ,  G01N33/74

CPC分类号： A61K38/27 ,  A61K38/24 ,  A61K47/02 ,  A61K47/12 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  G01N33/74 ,  C07K2319/00 ,  C07K2319/31 ,  G01N2333/65 ,  G01N2800/52

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US10166295B2

公开(公告)日：2019-01-01

申请号：US14725883

申请日：2015-05-29

申请人： Opko Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： A61K38/26 ,  A61K47/48 ,  A61K38/22

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US09821070B2

公开(公告)日：2017-11-21

申请号：US14592641

申请日：2015-01-08

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： A61K38/26 ,  A61K47/48 ,  A61K38/22

CPC分类号： A61K47/60 ,  A61K38/22 ,  A61K38/26

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US08999670B2

公开(公告)日：2015-04-07

申请号：US13867728

申请日：2013-04-22

申请人： OPKO Biologics Ltd.

发明人： Fuad Fares ,  Udi Eyal Fima

IPC分类号： C12N15/19 ,  A61K38/19 ,  A61K38/22 ,  C07K14/52 ,  C07K14/575 ,  C07K14/59 ,  C07K14/505 ,  A61K47/48 ,  C07K14/61

CPC分类号： C07K14/555 ,  A61K38/19 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35 ,  C07K2319/91

摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

摘要翻译： 公开了编码相同的多肽和多核苷酸，其包含连接于细胞因子的氨基末端的绒毛膜促性腺激素的一个羧基末端肽（CTP）和与细胞因子的羧基末端连接的绒毛膜促性腺激素的两个羧基末端肽（CTP）。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用方法。

公开(公告)号：US10538755B2

公开(公告)日：2020-01-21

申请号：US15484776

申请日：2017-04-11

申请人： Opko Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/36 ,  C07K14/745 ,  C07K1/107 ,  C12N9/00 ,  C12N9/96 ,  C12N9/64 ,  C07K14/59 ,  C07K14/505 ,  A61K38/00

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US10221228B2

公开(公告)日：2019-03-05

申请号：US14555353

申请日：2014-11-26

申请人： OPKO Biologics Ltd.

发明人： Fuad Fares ,  Udi Eyal Fima

IPC分类号： C07K14/605 ,  C12N15/62 ,  C07K14/59 ,  C07K14/505 ,  C07K14/555 ,  C07K14/61 ,  A61K38/00

CPC分类号： C07K14/59 ,  A61K38/00 ,  C07K14/505 ,  C07K14/555 ,  C07K14/605 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.