公开(公告)号：US20220000990A1

公开(公告)日：2022-01-06

申请号：US17189653

申请日：2021-03-02

Applicant: OPKO BIOLOGICS LTD.

Inventor： Udi Eyal FIMA ,  Gili Hart

IPC: A61K38/48 ,  C12N9/64 ,  A61P7/04 ,  A61K9/00

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

公开(公告)号：US09828417B2

公开(公告)日：2017-11-28

申请号：US14555258

申请日：2014-11-26

Applicant: OPKO Biologics Ltd.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K38/18 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K14/555

CPC classification number: C07K14/59 ,  C07K14/505 ,  C07K14/555 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35

Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US10538755B2

公开(公告)日：2020-01-21

申请号：US15484776

申请日：2017-04-11

Applicant: Opko Biologics Ltd.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K38/36 ,  C07K14/745 ,  C07K1/107 ,  C12N9/00 ,  C12N9/96 ,  C12N9/64 ,  C07K14/59 ,  C07K14/505 ,  A61K38/00

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US09249407B2

公开(公告)日：2016-02-02

申请号：US13932839

申请日：2013-07-01

Applicant: Opko Biologics Ltd.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K38/36 ,  C07K14/745 ,  C12N9/96 ,  C07K14/505 ,  C07K14/59 ,  C12N9/64 ,  A61K38/00 ,  A61K38/48

CPC classification number: C12N9/6437 ,  A61K38/00 ,  A61K38/4846 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/31 ,  C12N9/644 ,  C12N9/96 ,  C12Y304/21021

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US10960058B2

公开(公告)日：2021-03-30

申请号：US15737979

申请日：2016-06-19

Applicant: OPKO BIOLOGICS LTD.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K38/00 ,  C12Q1/56 ,  A61K9/19 ,  A61K9/64 ,  A61P7/04 ,  C07K14/59 ,  A61K38/48 ,  C12N9/64 ,  A61K9/00

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

公开(公告)号：US20150368630A9

公开(公告)日：2015-12-24

申请号：US13759860

申请日：2013-02-05

Applicant: Opko Biologics Ltd.

Inventor： Udi Eyal FIMA ,  Gili Hart

IPC: C12N9/50

CPC classification number: C12N9/50 ,  A61K38/00 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/02 ,  C07K2319/31 ,  C07K2319/91 ,  C12N9/6437 ,  C12N9/644 ,  C12Y304/21021

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

Abstract translation: 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码该羧基末端肽的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。

公开(公告)号：US20150079063A1

公开(公告)日：2015-03-19

申请号：US14274061

申请日：2014-05-09

Applicant: OPKO Biologics Ltd.

Inventor： Udi Eyal FIMA ,  Gili Hart

IPC: C12N9/96 ,  C07K14/59 ,  C12N9/64

CPC classification number: C12N9/96 ,  A61K38/00 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/31 ,  C12N9/6437 ,  C12N9/644

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

Abstract translation: 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码其的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。

公开(公告)号：US12203113B2

公开(公告)日：2025-01-21

申请号：US17379504

申请日：2021-07-19

Applicant: OPKO BIOLOGICS LTD.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K39/395 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K16/46 ,  C07K19/00 ,  C12N9/64 ,  C12N9/96 ,  A61K38/00 ,  A61K38/48

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US10144921B2

公开(公告)日：2018-12-04

申请号：US15159641

申请日：2016-05-19

Applicant: OPKO Biologics Ltd.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: C07K14/00 ,  C07K16/00 ,  A61K38/00 ,  C12N9/50 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C12N9/64 ,  A61K47/64

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US10119132B2

公开(公告)日：2018-11-06

申请号：US14948890

申请日：2015-11-23

Applicant: OPKO Biologics Ltd.

Inventor： Udi Eyal Fima ,  Gili Hart

IPC: A61K38/36 ,  C07K14/745 ,  C12N9/64 ,  C12N9/96 ,  C07K14/505 ,  C07K14/59 ,  A61K38/00 ,  A61K38/48

Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.