- 专利标题： Long-acting coagulation factors and methods of producing same
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申请号： US14274061申请日： 2014-05-09
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公开(公告)号： US09663778B2公开(公告)日： 2017-05-30
- 发明人: Udi Eyal Fima , Gili Hart
- 申请人： OPKO Biologics Ltd.
- 申请人地址： IL Nes Ziona
- 专利权人： OPKO Biologies Ltd.
- 当前专利权人： OPKO Biologies Ltd.
- 当前专利权人地址： IL Nes Ziona
- 代理机构： Pearl Cohen Zedek Latzer Baratz LLP
- 代理商 Mark S. Cohen
- 优先权： WOPCT/IL2013/050107 20120205
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N5/00 ; C07K14/745 ; C12N9/96 ; C12N9/64 ; C07K14/59 ; C07K14/505 ; A61K38/00
摘要：
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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