公开(公告)号：US20200239827A1

公开(公告)日：2020-07-30

申请号：US16745530

申请日：2020-01-17

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI ,  Tatsuya MINAMI ,  Yusuke MATSUMOTO

IPC: C12M1/00 ,  C12M1/34

Abstract: The present invention provides an erythrocyte-culture monitoring device including a light source that radiates monochromatic light onto a culture solution culturing erythrocytes accommodated in a culture container, a first photodetector that detects a light intensity of the monochromatic light transmitted through the culture solution, and a controller that evaluates an amount of hemoglobin in the culture solution based on a temporal change in the light intensity detected by the photodetector.

公开(公告)号：US20160270643A1

公开(公告)日：2016-09-22

申请号：US15169934

申请日：2016-06-01

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI

IPC: A61B1/06 ,  A61B1/015 ,  A61B1/018 ,  A61B1/005 ,  A61B1/05 ,  A61B1/00

CPC classification number: A61B1/0646 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00163 ,  A61B1/00186 ,  A61B1/0052 ,  A61B1/015 ,  A61B1/018 ,  A61B1/043 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0661 ,  G02B23/2469 ,  G06T3/4015 ,  H04N9/045 ,  H04N2209/046

Abstract: An endoscope apparatus includes: a light source unit that emits white illumination light or narrow band illumination light; an image sensor having pixels; a filter unit arranged corresponding to the pixels and including filters having a filter for passing blue light, and a filter for passing the blue light and one of green light and red light, the number of the filters for passing the green light being not less than half of the number of all the filters of the filter unit, and the number of the filters for passing the blue light being not less than the number of the filters for passing the green light; a selecting unit that selects, from the pixels, a luminance component pixel depending on types of illumination light; and a demosaicing processing unit that generates a color image signal having color components based on the luminance component pixel.

Abstract translation: 一种内窥镜装置，包括：发射白色照明光或窄带照明光的光源单元; 具有像素的图像传感器; 对应于像素布置的滤光器单元，包括具有用于通过蓝光的滤光器的滤光器，以及用于使蓝光和绿光和红光之一通过的滤光器，用于使绿光通过的滤光器数不小于 过滤器单元的所有滤光器的数量的一半，并且用于使蓝色光通过的滤光器的数量不小于用于通过绿色光的滤光器的数量; 选择单元，其从所述像素中选择取决于照明光的类型的亮度分量像素; 以及去马赛克处理单元，其基于所述亮度分量像素生成具有颜色分量的彩色图像信号。

公开(公告)号：US20200299630A1

公开(公告)日：2020-09-24

申请号：US16802665

申请日：2020-02-27

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI

IPC: C12M1/00 ,  C12M1/36 ,  C12M1/06 ,  C12M1/12 ,  C12M1/34 ,  G06T7/194 ,  H04N9/04 ,  H04N5/225 ,  G06T7/90

Abstract: Provided is a culture-medium-monitoring apparatus including: an optical measurement unit that includes an illumination light source and a collecting lens that radiate an illumination light onto a culturing liquid, a retroreflective member that has an array in which micro-reflective elements are arrayed, that is disposed so as to sandwich the vessel between the retroreflective member, and the illuminating light source and the collecting lens, and that reflects the illumination light passed through the culturing liquid in the vessel, and a light detector that detects an intensity of the illumination light passed through the culturing liquid in the vessel after being reflected by the retroreflective member; and a control portion that causes the intensity of the illumination light to be repeatedly detected at a prescribed timing, and that determines a state of the culturing liquid on the basis of a change over time in the intensity of the illumination light.

公开(公告)号：US20170296034A1

公开(公告)日：2017-10-19

申请号：US15637422

申请日：2017-06-29

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI

IPC: A61B1/00 ,  G02B23/24 ,  G06T7/00 ,  G06T7/11

CPC classification number: A61B1/00013 ,  A61B1/00009 ,  A61B1/2733 ,  G02B23/2461 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/20036

Abstract: An image processing apparatus interpolates a signal of a missing color component based on first, second, and third color signals respectively generated by first, second, and third pixels of an image sensor, to generate color signals. These pixels are arranged in a matrix. The first pixels generate the first color signal of a first luminance component of white light. The second pixels generate the second color signal of a second luminance component of narrow band light. Density of the first pixels being higher than density of the second pixels and density of the third pixels. The apparatus extracts a specific frequency component signal from a color signal of the first luminance component among the color signals generated by interpolation, and adds the specific frequency component signal to a color signal of a color component different from the first luminance component depending on white light imaging or narrow band imaging.

公开(公告)号：US20170243325A1

公开(公告)日：2017-08-24

申请号：US15587921

申请日：2017-05-05

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI

IPC: G06T3/40 ,  H04N9/07 ,  H04N5/225 ,  A61B1/04 ,  A61B1/06

CPC classification number: G06T3/4007 ,  A61B1/00009 ,  A61B1/04 ,  A61B1/0638 ,  G02B23/2484 ,  G02B26/008 ,  H04N5/2256 ,  H04N9/07 ,  H04N2005/2255 ,  H04N2209/044 ,  H04N2209/046

Abstract: An image sensor includes first and second pixels to generate a first electric signal from white illumination light and second electric signals from narrow band illumination light, respectively. Density of the first pixels is higher than density of each color components of the second pixels. An image processing apparatus is configured to: interpolate the first electric signal based on the first pixels surrounding the second pixels to generate an interpolated electric signal; calculate a difference between the interpolated electric signal and the second electric signals to generate a color difference signal; discriminate an interpolation direction based on the color difference signal to interpolate a missing color difference signal at each pixel position, thereby generating an interpolated color difference signal; and generate the second electric signals to be generated by the second pixels, based on the interpolated color difference signal and the interpolated electric signal.

公开(公告)号：US20130286172A1

公开(公告)日：2013-10-31

申请号：US13925197

申请日：2013-06-24

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi SASAKI

IPC: A61B1/00

CPC classification number: A61B1/00009 ,  A61B1/00188 ,  A61B1/045 ,  G02B23/2476 ,  G06T5/003 ,  G06T5/50 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/10068 ,  G06T2207/10148 ,  G06T2207/20221 ,  H04N5/23212 ,  H04N5/23232 ,  H04N5/23296 ,  H04N2005/2255

Abstract: The endoscope apparatus includes an image acquisition section (image composition processing section) that acquires a captured image in a zoom observation state in time series, the zoom observation state being an observation state in which a magnification of an optical system is higher than that in a normal observation state, a defocus amount information extraction section (texture extraction section) that extracts defocus amount information from the captured image in the zoom observation state, and a defocus amount correction section (texture correction amount calculation section, texture correction section, and blending section) that corrects the captured image based on the extracted defocus amount information.

Abstract translation: 所述内窥镜装置包括以时间序列取得变焦观察状态的拍摄图像的图像获取部（图像构图处理部），所述变焦观察状态为光学系统的倍率高于 正常观察状态，在变焦观察状态下从拍摄图像提取散焦量信息的散焦量信息提取部（纹理提取部）和散焦量校正部（纹理校正量计算部，纹理校正部，混合部 ），其基于提取的散焦量信息来校正所捕获的图像。

公开(公告)号：US20130250391A1

公开(公告)日：2013-09-26

申请号：US13801899

申请日：2013-03-13

Applicant: OLYMPUS CORPORATION

Inventor： Jun KATO ,  Hiroshi SASAKI ,  Yujin ARAI

IPC: G02B21/06 ,  G02B21/36

CPC classification number: G02B21/06 ,  G02B21/082 ,  G02B21/16 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367

Abstract: A laser microscope includes an objective lens that radiates a laser beam onto a specimen; a stimulation optical system having an LCOS-SLM located at a position optically conjugate with the pupil position of the objective lens and which modulates the phase of the laser beam; and an observation optical system having a galvanometer mirror that scans the laser beam across the specimen, as observation illuminating light, and a PMT that detects the observation light coming from the specimen and collected by the objective lens. A control unit forms a three-dimensional image of the specimen and sets, in that image, stimulation sites in the specimen to be irradiated with a laser beam serving as a stimulation beam by the stimulation optical system at a plurality of different positions in the optical axis direction. The LCOS-SLM modulates the laser beam such that the stimulation sites are irradiated with the laser beam.

Abstract translation: 激光显微镜包括将激光束照射到样品上的物镜; 刺激光学系统，其具有位于与物镜的光瞳位置光学共轭的位置并且调制激光束的相位的LCOS-SLM; 以及具有扫描横跨试样的激光束作为观察照明光的检流计镜的观察光学系统，以及检测来自样本并由物镜收集的观察光的PMT。 控制单元形成样本的三维图像，并且在该图像中，通过刺激光学系统在光学器件中的多个不同位置处设置用于作为刺激光束的激光束照射的样本中的刺激部位 轴方向。 LCOS-SLM调制激光束，使激光位置用激光束照射。