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公开(公告)号：US08796615B2
公开(公告)日：2014-08-05
申请号：US13848504
申请日：2013-03-21
Applicant: Micromass UK Limited
Inventor： Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
CPC classification number: H01J49/4205 , H01J49/02 , H01J49/4225
Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
Abstract translation: 公开了一种质谱仪，其包括四极杆组离子阱，其中在一个径向方向上随半径增加而在离子阱的出口产生电势场。 离子阱内的离子质量选择性地沿径向激发。 已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱轴向喷出。
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公开(公告)号：US20140131568A1
公开(公告)日：2014-05-15
申请号：US14158111
申请日：2014-01-17
Applicant: Micromass UK Limited
Inventor： Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
CPC classification number: H01J49/4205 , H01J49/02 , H01J49/4225
Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the on trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
Abstract translation: 公开了一种质谱仪，其包括四极杆组离子阱，其中在一个径向方向上随半径增加而在离子阱的出口产生电势场。 在阱内的离子质量选择性地沿径向激发。 已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱轴向喷出。
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公开(公告)号：US20240194471A1
公开(公告)日：2024-06-13
申请号：US18556409
申请日：2022-04-21
Applicant: Micromass UK Limited
Inventor： Ian Trivett , Mark Walford , Daniel James Kenny , Stevan Bajic , Suloke Mathai
CPC classification number: H01J49/167 , H01J49/045
Abstract: A nebuliser outlet (20) comprises one or more first channels (24), wherein the nebuliser outlet (20) is configured such that liquid received by the nebuliser outlet (20) can pass to one or more nebulisation regions via the one or more first channels (24), and one or more second channels (25), wherein the nebuliser outlet (20) is configured such that gas received by the nebuliser outlet (20) can pass to the one or more nebulisation regions via the one or more second channels (25). The one or more first channels (24) comprise a first portion (24a) and a second portion (24b), wherein the first portion (24a) comprises a tubular channel, and wherein the second portion (24b) comprises multiple channels, an annular channel, or a segmented annular channel. The one or more second channels (25) converge with the second portion (24b) at the one or more nebulisation regions.
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公开(公告)号：US20220163480A1
公开(公告)日：2022-05-26
申请号：US17599312
申请日：2020-03-27
Applicant: Micromass UK Limited
Inventor： Martin Palmer , Eleanor Riches , Jakub Ujma , Jason Lee Wildgoose , Martin Raymond Green , David J. Langridge , Kevin Giles , Steven Derek Pringle , Daniel James Kenny
IPC: G01N27/622 , H01J49/00 , H01J49/40
Abstract: A method of selecting ions comprises selecting ions corresponding to a target ion of interest by separating analyte ions according to their ion mobility, isolating first ions of the analyte ions, separating the first ions according to their ion mobility, and isolating second ions of the first ions. Preferably, the separation is accomplished by using a cyclic or closed-loop separator.
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公开(公告)号：US20190244800A1
公开(公告)日：2019-08-08
申请号：US16256687
申请日：2019-01-24
Applicant: Micromass UK Limited
Inventor： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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Patent Agency Ranking
公开(公告)号：US10354847B2
公开(公告)日：2019-07-16
申请号：US16020482
申请日：2018-06-27
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump 707 is arranged and adapted to maintain the first vacuum chamber at a pressure
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公开(公告)号：US10217623B2
公开(公告)日：2019-02-26
申请号：US15317731
申请日：2015-06-12
Applicant: Micromass UK Limited
Inventor： Jeffery Mark Brown , David Gordon , Daniel James Kenny , Paul Murray
Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analyzing the analyte ions with a mass analyzer and/or ion mobility analyzer. Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.
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公开(公告)号：US10199205B2
公开(公告)日：2019-02-05
申请号：US15852412
申请日：2017-12-22
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyzer, a 3D ion trap mass analyzer, a 2D or linear ion trap mass analyzer, a Time of Flight mass analyzer, a quadrupole-Time of Flight mass analyzer or an electrostatic mass analyzer arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.
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公开(公告)号：US10128092B2
公开(公告)日：2018-11-13
申请号：US14892374
申请日：2014-05-29
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
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公开(公告)号：US10090138B2
公开(公告)日：2018-10-02
申请号：US14892406
申请日：2014-05-29
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.
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