公开(公告)号：US11724265B2

公开(公告)日：2023-08-15

申请号：US17169030

申请日：2021-02-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kristopher Barbee ,  Rui Zheng ,  Sean McCusker

IPC: B04B7/08 ,  B04B5/04 ,  B01D21/26 ,  B04B11/04 ,  G01N35/00 ,  G01N35/04

CPC classification number: B04B7/08 ,  B01D21/262 ,  B04B5/0421 ,  B04B2011/046 ,  G01N2035/00158 ,  G01N2035/00495 ,  G01N2035/0449

Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.

公开(公告)号：US10401372B2

公开(公告)日：2019-09-03

申请号：US15392372

申请日：2016-12-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kristopher Barbee ,  Maximilian Carpino ,  Ray Wheeling ,  Nicholas Peter Bajka

IPC: G01N35/00 ,  G01N35/10

Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.

公开(公告)号：US20190219603A1

公开(公告)日：2019-07-18

申请号：US16194187

申请日：2018-11-16

Applicant: Life Technologies Corporation

Inventor： Kristopher Barbee ,  Maximilian Carpino ,  Ray Wheeling ,  Nicholas Bajka

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/0098 ,  G01N35/0099 ,  G01N35/10 ,  G01N35/1009 ,  Y10T436/255

Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.

公开(公告)号：US10144015B2

公开(公告)日：2018-12-04

申请号：US14536489

申请日：2014-11-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kristopher Barbee ,  Rui Zheng ,  Sean McCusker

IPC: B04B7/08 ,  B01D21/26 ,  B04B5/04 ,  B04B11/04 ,  G01N35/00 ,  G01N35/04

Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.

公开(公告)号：US09476854B2

公开(公告)日：2016-10-25

申请号：US15040815

申请日：2016-02-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kristopher Barbee ,  John F. Davidson ,  Wolfgang Hinz ,  Shifeng Li ,  James Bustillo

IPC: G01N27/414 ,  B01J19/00

CPC classification number: G01N27/4473 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00704 ,  B01J2219/00722 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N27/4148 ,  G01N27/44743

Abstract: An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.

Abstract translation: 一种装置包括包括传感器阵列的装置基板。 传感器阵列的每个传感器可以包括设置在器件基板的表面处的电极结构。 该装置还包括覆盖在装置基板的表面上的壁结构，并且限定至少部分对应于传感器阵列的一组阱阵列。 阱结构包括电极层和绝缘层。

公开(公告)号：US20150087025A1

公开(公告)日：2015-03-26

申请号：US14558948

申请日：2014-12-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kristopher Barbee ,  Maximilian Carpino ,  Ray Wheeling ,  Nicholas Peter Bajka

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/0098 ,  G01N35/0099 ,  G01N35/10 ,  G01N35/1009 ,  Y10T436/255

Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.

Abstract translation: 本教导提供了用于自动处理样品（例如生物或化学样品）的设备和方法。 本教导的装置和方法允许自动执行各种样品操作步骤而无需手动干预。 在优选的实施方案中，本发明提供了通过PCR产生的模板化珠的自动富集的装置和方法。