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![Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors](/abs-image/US/2017/08/29/US09745311B2/abs.jpg.150x150.jpg)
公开(公告)号：US09745311B2
公开(公告)日：2017-08-29
申请号：US15181903
申请日：2016-06-14
发明人： Liang Lu , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , C07D495/04 , C07D519/00
CPC分类号： C07D487/04 , C07D495/04 , C07D519/00
摘要： The present invention relates to pyrazine derivatives of Formula I, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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12.发明授权Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors 有权可用作Pim激酶抑制剂的噻唑甲酰胺和吡啶甲酰胺化合物公开(公告)号：US09550765B2
公开(公告)日：2017-01-24
申请号：US14811038
申请日：2015-07-28
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Ke Zhang , Wenqing Yao
IPC分类号： A61K31/444 , C07D471/04 , C07D495/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D491/048
CPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
摘要翻译： 本公开描述了噻唑和吡啶甲酰胺衍生物，其组合物和使用方法。 所述化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶的活性相关的疾病，包括例如癌症和其它疾病。
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![Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors](/abs-image/US/2016/07/12/US09388185B2/abs.jpg.150x150.jpg)
公开(公告)号：US09388185B2
公开(公告)日：2016-07-12
申请号：US13963569
申请日：2013-08-09
发明人： Liang Lu , Chunhong He , Wenqing Yao
IPC分类号： A61K31/4985 , C07D241/38 , C07D487/04 , C07D495/04
CPC分类号： C07D487/04 , C07D495/04 , C07D519/00
摘要： The present invention relates to pyrazine derivatives of Formula I, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
摘要翻译： 本发明涉及式I的吡嗪衍生物和包含其的药物组合物，其是一种或多种FGFR酶的抑制剂，并且可用于治疗FGFR相关疾病如癌症。
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公开(公告)号：US09371323B2
公开(公告)日：2016-06-21
申请号：US14680745
申请日：2015-04-07
发明人： Wenqing Yao , Jincong Zhuo , Colin Zhang
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
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15.发明申请THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS 有权作为PIM激酶抑制剂有用的噻唑并恶唑和吡啶甲酰胺化合物公开(公告)号：US20150329534A1
公开(公告)日：2015-11-19
申请号：US14811038
申请日：2015-07-28
发明人： Chu-Biao Xue , Yun-Long Li , Hao Feng , Jun Pan , Anlai Wang , Ke Zhang , Wenqing Yao , Fenglei Zhang , Jincong Zhuo
IPC分类号： C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
CPC分类号： A61K31/444 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
摘要翻译： 本公开描述了噻唑和吡啶甲酰胺衍生物，其组合物和使用方法。 所述化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶的活性相关的疾病，包括例如癌症和其它疾病。
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公开(公告)号：US11530214B2
公开(公告)日：2022-12-20
申请号：US17160628
申请日：2021-01-28
发明人： Liang Lu , Wenqing Yao , Chunhong He , Fenglei Zhang
IPC分类号： A61P35/00 , A61K31/4375 , C07D471/04
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US10947230B2
公开(公告)日：2021-03-16
申请号：US16566509
申请日：2019-09-10
发明人： Yaping Sun , Wenqing Yao , Liangxing Wu , Meizhong Xu , Ding-Quan Qian , Fenglei Zhang
IPC分类号： C07D471/04 , A61P35/00 , A61K31/4375
摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
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公开(公告)号：US20200323858A1
公开(公告)日：2020-10-15
申请号：US16828315
申请日：2020-03-24
发明人： Yun-Long Li , Wenqing Yao , Andrew P. Combs , Eddy W. Yue , Song Mei , Joseph Glenn , Thomas P. Maduskuie, Jr. , Richard B. Sparks , Brent Douty , Chunhong He
IPC分类号： A61K31/519 , A61P29/00 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
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公开(公告)号：US20200317680A1
公开(公告)日：2020-10-08
申请号：US16909686
申请日：2020-06-23
发明人： Jincong Zhuo , Meizhong Xu , Chunhong He , Colin Zhang , Ding-Quan Qian , David M. Burns , Yun-Long Li , Brian Metcalf , Wenqing Yao
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4709 , C07D403/06 , A61P35/00
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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![IMIDAZO[1,2-B][1,2,4]TRIAZINES AS C-MET INHIBITORS](/abs-image/US/2020/08/06/US20200247811A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200247811A1
公开(公告)日：2020-08-06
申请号：US16593588
申请日：2019-10-04
发明人： Jincong Zhuo , Chunhong He , Wenqing Yao
IPC分类号： C07D487/04 , A61K31/53 , C07D403/04 , A61P35/00
摘要： The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
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