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![Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones](/abs-image/US/2019/10/15/US10442809B2/abs.jpg.150x150.jpg)
11.发明授权公开(公告)号：US10442809B2
公开(公告)日：2019-10-15
申请号：US15956835
申请日：2018-04-19
申请人： IMMUNOGEN, INC.
IPC分类号： C07D243/10 , C07D487/04 , C07D209/12
摘要： The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors. In an embodiment, the method discloses preparation of a compound represented by formula (III):
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公开(公告)号：US10392407B2
公开(公告)日：2019-08-27
申请号：US15860864
申请日：2018-01-03
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , C07D519/00 , C07K5/083
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US20180339989A1
公开(公告)日：2018-11-29
申请号：US15956835
申请日：2018-04-19
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , C07D209/12
CPC分类号： C07D487/04 , C07D209/12
摘要： The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
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公开(公告)号：US10081640B2
公开(公告)日：2018-09-25
申请号：US15216548
申请日：2016-07-21
申请人： ImmunoGen, Inc.
IPC分类号： C07K17/00 , A61K38/06 , C07K5/00 , C07K7/00 , C07K16/00 , C07D519/00 , C07D487/04 , C07K5/083
CPC分类号： C07D519/00 , C07D487/04 , C07K5/0804
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US11981687B2
公开(公告)日：2024-05-14
申请号：US17841026
申请日：2022-06-15
申请人： IMMUNOGEN, INC.
IPC分类号： C07D207/452 , C07C205/19 , C07D487/04 , C07D519/00 , C07D519/04
CPC分类号： C07D519/00 , C07C205/19 , C07D207/452 , C07D487/04 , C07D519/04
摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US20230233697A1
公开(公告)日：2023-07-27
申请号：US17973209
申请日：2022-10-25
申请人： IMMUNOGEN, INC.
IPC分类号： A61K47/64 , C07K5/02 , C07K16/28 , C07K5/113 , C07D519/00 , C07D487/04 , C07K5/093 , A61K39/00
CPC分类号： A61K47/64 , C07K5/0202 , C07K16/2866 , C07K16/2863 , C07K5/1021 , C07D519/00 , C07K16/28 , C07D487/04 , C07K5/0819 , C07K2317/24 , A61K2039/505 , C07K2317/92
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20210171546A1
公开(公告)日：2021-06-10
申请号：US16991700
申请日：2020-08-12
申请人： IMMUNOGEN, INC.
IPC分类号： C07D519/00 , C07K5/083 , C07D487/04
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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![Methods of preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indoles](/abs-image/US/2021/04/06/US10968228B2/abs.jpg.150x150.jpg)
18.发明授权公开(公告)号：US10968228B2
公开(公告)日：2021-04-06
申请号：US16560379
申请日：2019-09-04
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/22 , C07D487/04 , C07D209/12
摘要： The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds of formula (I) below and their synthetic precursors:
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公开(公告)号：US20200017526A1
公开(公告)日：2020-01-16
申请号：US16448261
申请日：2019-06-21
申请人： IMMUNOGEN, INC.
IPC分类号： C07D519/00 , C07D487/04 , C07K5/083
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US20190269786A1
公开(公告)日：2019-09-05
申请号：US16274665
申请日：2019-02-13
申请人： IMMUNOGEN, INC.
IPC分类号： A61K47/64 , C07K16/28 , C07D519/00 , C07K5/02 , C07K5/113 , C07K5/093 , C07D487/04
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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