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公开(公告)号：US20180065062A1
公开(公告)日：2018-03-08
申请号：US15545233
申请日：2016-05-27
发明人： Carol A. Rae , Jan S. Simoni , John F. Moeller
CPC分类号： B01D15/20 , A61K35/00 , A61K35/14 , B01D15/34 , B01D15/3804 , B01D15/3847 , B01J20/048 , B01J20/20 , B01J20/28004 , B01J20/28038 , B01J20/28057
摘要： A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant.to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized.
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12.发明公开公开(公告)号：US20240165314A1
公开(公告)日：2024-05-23
申请号：US18396143
申请日：2023-12-26
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , A61M1/0281 , A61M1/14 , A61M1/3687 , B01J20/20 , B01J47/02
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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13.发明授权公开(公告)号：US10773011B2
公开(公告)日：2020-09-15
申请号：US15584796
申请日：2017-05-02
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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公开(公告)号：US10137151B2
公开(公告)日：2018-11-27
申请号：US15500893
申请日：2015-04-17
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61M1/36 , B01J47/026 , A61K9/14
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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15.发明申请公开(公告)号：US20170232183A1
公开(公告)日：2017-08-17
申请号：US15584796
申请日：2017-05-02
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , A61M5/165 , A61M2202/0021 , A61M2202/0042 , A61M2202/0413 , A61M2202/206 , B01J20/20 , B01J47/02
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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公开(公告)号：US20240100090A1
公开(公告)日：2024-03-28
申请号：US18385027
申请日：2023-10-30
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61K9/14 , A61M1/36 , B01J47/026
CPC分类号： A61K33/44 , A61K9/14 , A61M1/3679 , B01J47/026
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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公开(公告)号：US20210236543A1
公开(公告)日：2021-08-05
申请号：US17213561
申请日：2021-03-26
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61M1/36 , B01J47/026 , A61K9/14
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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18.发明申请公开(公告)号：US20210052803A1
公开(公告)日：2021-02-25
申请号：US17091214
申请日：2020-11-06
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller , Jose A. Diaz-Aunon
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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公开(公告)号：US20190105631A1
公开(公告)日：2019-04-11
申请号：US16088785
申请日：2017-03-31
发明人： Carol A. Rae , Jan Simoni , John F. Moeller
摘要： A three-component composition for use in the treatment of preeclampsia and related disorders wherein a first component comprises a bimodal synthetic carbon particle mixture; a second component comprises a resin bead with at least one affinity ligand directed toward syncytiotrophoblast-derived factor sEndoglin and a third component comprises a resin bead with at least one affinity ligand directed toward syncytiotrophoblast-derived factor soluble Fms-like tyrosine kinase-1.
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公开(公告)号：US20170258832A1
公开(公告)日：2017-09-14
申请号：US15500893
申请日：2015-04-17
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , B01J47/026 , A61M1/36
CPC分类号： A61K33/44 , A61K9/14 , A61M1/3679 , B01J47/026
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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