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1.发明授权公开(公告)号：US11918728B2
公开(公告)日：2024-03-05
申请号：US17091214
申请日：2020-11-06
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller , Jose A. Diaz-Aunon
CPC分类号： A61M1/3679 , B01J20/20 , B01J47/02 , A61M5/165 , A61M2202/0021 , A61M2202/0042 , A61M2202/0413 , A61M2202/206
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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2.发明授权公开(公告)号：US09669151B2
公开(公告)日：2017-06-06
申请号：US14642538
申请日：2015-03-09
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , A61M5/165 , A61M2202/0021 , A61M2202/0042 , A61M2202/0413 , A61M2202/206 , B01J20/20 , B01J47/02
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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3.发明公开公开(公告)号：US20230372596A1
公开(公告)日：2023-11-23
申请号：US18230040
申请日：2023-08-03
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , B01J20/20 , B01J47/02 , A61M2202/206 , A61M5/165
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a third filtrate.
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公开(公告)号：US11253794B2
公开(公告)日：2022-02-22
申请号：US15545233
申请日：2016-05-27
发明人： Carol A. Rae , Jan S. Simoni , John F. Moeller
IPC分类号： B01D15/20 , B01D15/38 , B01J20/04 , B01J20/28 , A61K35/14 , B01D15/34 , B01J20/20 , A61K35/00
摘要： A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; and recovering the cleansed product. A method of preparing a universal blood product comprising obtaining a blood product; contacting the blood product with (i) hydroxyapatite; (ii) a carbonaceous material comprising at least a mixture of a first carbon particle having macroporous size α and a second carbon particle having macroporous size β; and (iii) at least one support matrix chemically associated with an antigenic determinant. to form a cleansed product; wherein at least one of the hydroxyapatite, carbonaceous material and support matrix is functionalized.
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公开(公告)号：US10960022B2
公开(公告)日：2021-03-30
申请号：US16161546
申请日：2018-10-16
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61M1/36 , B01J47/026 , A61K9/14
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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6.发明申请公开(公告)号：US20170304524A1
公开(公告)日：2017-10-26
申请号：US15513221
申请日：2015-11-18
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , A61M1/0281 , A61M1/14 , A61M1/3687 , B01J20/20 , B01J47/02
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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7.发明授权公开(公告)号：US11896753B2
公开(公告)日：2024-02-13
申请号：US16807858
申请日：2020-03-03
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , A61M1/0281 , A61M1/14 , A61M1/3687 , B01J20/20 , B01J47/02
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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公开(公告)号：US11839628B2
公开(公告)日：2023-12-12
申请号：US17213561
申请日：2021-03-26
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61M1/36 , B01J47/026 , A61K9/14
CPC分类号： A61K33/44 , A61K9/14 , A61M1/3679 , B01J47/026
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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9.发明授权公开(公告)号：US11759561B2
公开(公告)日：2023-09-19
申请号：US17008783
申请日：2020-09-01
发明人： Carol A. Rae , Jan Simoni , Grace Simoni , John F. Moeller
CPC分类号： A61M1/3679 , B01J20/20 , B01J47/02 , A61M5/165 , A61M2202/0021 , A61M2202/0042 , A61M2202/0413 , A61M2202/206
摘要： A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
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公开(公告)号：US20190046567A1
公开(公告)日：2019-02-14
申请号：US16161546
申请日：2018-10-16
发明人： Carol A Rae , Jan Simoni , Grace Simoni , John F. Moeller
IPC分类号： A61K33/44 , A61K9/14 , A61M1/36 , B01J47/026
摘要： A three component composition for use in the treatment of an autoimmune disease where the first component comprises a bimodal synthetic carbon particle mixture; the second component comprises a bimodal synthetic carbon particle mixture and an anion exchange resin and the third component comprises a bimodal synthetic carbon particle mixture and a cation exchange resin.
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