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37 条记录 (耗时 0.033 秒)

    6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof
    12.
    发明授权
    6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof 失效
    6-取代的4-羟基噌啉-3-基 - 羧酸及其酯

    公开(公告)号：US4085103A

    公开(公告)日：1978-04-18

    申请号：US794114

    申请日：1977-05-05

    申请人： John Preston ,  Austin John Reeve

    发明人： John Preston ,  Austin John Reeve

    IPC分类号： C07D237/28

    CPC分类号： C07D237/28

    摘要： 6-Dimethylamino-4-hydroxycinnolin-3-yl carboxylic acid; ethyl 6-n-but-2-ylamino-4-hydroxycinnolin-3-yl carboxylate or the pharmaceutically-acceptable acid-addition salts thereof. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.

    摘要翻译： 6-二甲基氨基-4-羟基噌啉-3-基羧酸; 6-正丁基-2-基氨基-4-羟基噌啉-3-基甲酸乙酯或其药学上可接受的酸加成盐。 这些化合物作为抑制剂作为效应的抑制剂，与抗原样抗体及其抗原组合。

    Method and apparatus for organizing and scheduling multimedia data transfers over a wireless channel
    14.
    发明申请
    Method and apparatus for organizing and scheduling multimedia data transfers over a wireless channel 审中-公开

    公开(公告)号：US20060092910A1

    公开(公告)日：2006-05-04

    申请号：US11299136

    申请日：2005-12-08

    申请人： Gregory Dertz ,  Alan Conrad ,  Robert LoGalbo ,  John Preston ,  Tyrone Bekiares ,  Donald Newberg

    发明人： Gregory Dertz ,  Alan Conrad ,  Robert LoGalbo ,  John Preston ,  Tyrone Bekiares ,  Donald Newberg

    IPC分类号： H04B7/212

    CPC分类号： H04W72/1242

    摘要： A radio frequency communications system (100) includes wireless terminals (102) and base sites (104). The wireless terminals communicate with the base sites over a radio frequency channel (106). The base sites are interconnected to each other and other network elements via a packet network. The communication system has a radio frequency channel (400) with time slots (406, 408) for transmission of both delay-sensitive data, such as streaming audio and video, and non-delay-sensitive data. A method and apparatus are provided for determining whether a time slot in the radio frequency channel is to be allocated to delay-sensitive data or non-delay-sensitive data (704, 706, 708). Each packet of data transmitted over the wireless channel has a type of service field (900). The type of service field has a precedence or priority value (902) and a service type (904). The priority values are used to determine which packet should be transmitted across the radio frequency channel next and the service type determines the transmission protocol.

    (Hetero) aryl-sulfonamide derivatives, their preparation and their use as factor XA inhibitors
    15.
    发明授权
    (Hetero) aryl-sulfonamide derivatives, their preparation and their use as factor XA inhibitors 失效
    （杂芳基）磺酰胺衍生物，它们的制备及其作为因子XA抑制剂的用途

    公开(公告)号：US06486154B1

    公开(公告)日：2002-11-26

    申请号：US09463446

    申请日：2000-01-27

    申请人： Andrew Stocker ,  John Preston

    发明人： Andrew Stocker ,  John Preston

    IPC分类号： A61K3154

    CPC分类号： C07D401/04

    摘要： A compound of formula (I), or a pharmaceutically-acceptable salt thereof, wherein A is an optionally substituted 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms; B is optionally substituted phenylene or a 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen heteroatoms; R and R1 are hydrogen or (1-4C)alkyl; n is 1 or 2; R2 and R3 are hydrogen, (1-6C)alkyl, (4-7C)cycloalkyl, or (2-6C)alkenyl, or R2 and R3 may form along with the nitrogen to which they are attached a 5-, 6- or 7-membered heterocyclic ring, wherein each R2 or R3 group or any heterocyclic ring formed from R2 and R3 may be optionally substituted with various substituent groups, and wherein Q may be optionally substituted by various substituent groups, which posseses antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention relates to processes for the preparation of the compounds represented by formula (I), to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

    摘要翻译： 式（I）化合物或其药学上可接受的盐，其中A是含有1,2或3个环杂原子的任选取代的5元或6元单环芳环; B是任选取代的亚苯基或含有1,2或3个氮杂原子的6元杂环; R和R 1是氢或（1-4C）烷基; n为1或2; R2和R3是氢，（1-6C）烷基，（4-7C）环烷基或（2-6C）烯基，或R2和R3可以与它们所连接的氮一起形成5-，6-或 7元杂环，其中每个R 2或R 3基团或由R 2和R 3形成的任何杂环可以任选被各种取代基取代，并且其中Q可任选地被各种取代基取代，这些取代基具有抗血栓形成和抗凝血性质， 因此在治疗人或动物的方法中有用。 本发明涉及制备由式（I）表示的化合物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。

    Modular building construction using composite interconnected frame panels
    18.
    发明授权
    Modular building construction using composite interconnected frame panels 有权

    公开(公告)号：US10253465B2

    公开(公告)日：2019-04-09

    申请号：US15637418

    申请日：2017-06-29

    申请人： John Preston

    发明人： John Preston

    IPC分类号： E04B1/24 ,  E01D18/00 ,  E04F11/035 ,  E04B2/00 ,  E04C2/00 ,  E04G1/17 ,  E04G21/32 ,  E04B1/348

    摘要： A building module for use in construction of a structure incorporating a plurality of said modules which together form at least part of the structure. Each building module comprises a first peripheral frame of a first size defining a space which receives a layer of barrier material, a second peripheral frame of a second size defining a space which receives a layer of barrier material and which is joined at a first junction to the first peripheral frame of the first size in abutting end to end relationship to form a first auxiliary module. A third peripheral frame has the same size as the first peripheral frame and which defines a space which receives a layer of barrier material. A fourth peripheral frame has the same size as the second peripheral frame and which defines a space which receives a layer of barrier material and which is joined at a second junction to the third peripheral frame of the first size in abutting end to end relationship to form a second auxiliary module. The first and second auxiliary modules are attached side by side to form said building module; wherein the first and second auxiliary modules are attached to each other so that the first and second junctions are staggered along the length of the structure.

    Method and system for facilitating command of a group
    19.
    发明申请
    Method and system for facilitating command of a group 审中-公开
    促进组织指挥的方法和系统

    公开(公告)号：US20070183343A1

    公开(公告)日：2007-08-09

    申请号：US11347408

    申请日：2006-02-03

    申请人： Liliana Grajales ,  Mark Krizik ,  Ion Nicolaescu ,  John Preston ,  Francesca Schuler ,  Mansour Toloo

    发明人： Liliana Grajales ,  Mark Krizik ,  Ion Nicolaescu ,  John Preston ,  Francesca Schuler ,  Mansour Toloo

    IPC分类号： H04L12/28 ,  H04Q7/38

    CPC分类号： G06Q10/00 ,  H04W84/18

    摘要： A method and system for facilitating command of a group determines a present rank protocol associated with users of an ad hoc wireless communication network. The method includes identifying at a first wireless device a second wireless device in operative communication with the first wireless device (step 805). A physical parameter measured at the first wireless device is then compared with a physical parameter measured at the second wireless device and wirelessly received at the first wireless device (step 810). A base rank of a user of the first wireless device is then compared with a base rank of a user of the second wireless device (step 815). A present rank of the user of the first wireless device is then determined relative to a present rank of the user of the second wireless device based on comparisons of the physical parameters and the base ranks (step 820).

    摘要翻译： 用于促进组的命令的方法和系统确定与自组织无线通信网络的用户相关联的当前秩协议。 该方法包括在第一无线设备处识别与第一无线设备操作通信的第二无线设备（步骤805）。 然后将在第一无线设备处测量的物理参数与在第二无线设备处测量并在第一无线设备处无线地接收的物理参数进行比较（步骤810）。 然后将第一无线设备的用户的基本等级与第二无线设备的用户的基本级别进行比较（步骤815）。 然后基于物理参数和基本等级的比较，相对于第二无线设备的用户的当前等级来确定第一无线设备的用户的当前等级（步骤820）。

    Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
    20.
    发明授权
    Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents 失效
    氨基杂环衍生物作为抗血栓形成或抗凝血剂

    公开(公告)号：US07173025B1

    公开(公告)日：2007-02-06

    申请号：US09117436

    申请日：1997-01-31

    申请人： Andrew Stocker ,  John Preston ,  Michael James Smithers

    发明人： Andrew Stocker ,  John Preston ,  Michael James Smithers

    IPC分类号： A61K31/55 ,  A61K31/495 ,  C07D401/00 ,  C07D223/00

    CPC分类号： C07D401/14 ,  C07D213/74 ,  C07D237/20 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12

    摘要： Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents; L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X1 and X2 represent various linking groups; Ar is phenylene or certain heteroaryl rings and Q represents a variety of aromatic or heterocyclic rings systems, and pharmaceutically acceptable salts thereof are described as useful antithrombotic and anticoagulant agents, and are selective Factor Xa inhibitors. Processes for their preparation and pharmaceutical compositions containing them are also described.

    摘要翻译： 式（I）的化合物，其中G 1是CH或N; G 是CH或N; R 1是各种任选的取代基; L 1是（1-4C）亚烷基; T 1是CH或N; R 2和R 3独立地是氢或（1-4C）烷基或连接形成环; X 1和X 2代表各种连接基团; Ar是亚苯基或某些杂芳基环，Q表示各种芳族或杂环体系，其药学上可接受的盐被描述为有用的抗血栓形成和抗凝血剂，并且是选择性因子Xa抑制剂。 还描述了其制备方法和含有它们的药物组合物。