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公开(公告)号：US11214789B2
公开(公告)日：2022-01-04
申请号：US16124184
申请日：2018-09-06
发明人： Bart Lipkens , Walter M. Presz, Jr. , Brian Dutra , Jason Dionne , Goutam Ghoshal , Kedar C. Chitale
摘要： Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
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公开(公告)号：US10724029B2
公开(公告)日：2020-07-28
申请号：US15647223
申请日：2017-07-11
IPC分类号： C12N13/00 , B01D21/28 , H01L41/053 , B01D17/04 , C12M1/00 , B06B1/06 , H01L41/09 , H01L41/187
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：US10322949B2
公开(公告)日：2019-06-18
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, Jr. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
IPC分类号： C02F1/36 , B06B1/06 , B01D17/04 , C02F1/40 , B01D19/00 , B01D21/28 , C12M1/42 , G10K11/28 , C12N1/02 , C12N13/00 , C12M1/00 , H01L41/09
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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14.发明授权公开(公告)号：US09533241B2
公开(公告)日：2017-01-03
申请号：US15080354
申请日：2016-03-24
CPC分类号： B01D21/283 , C02F1/36 , C12M47/02
摘要： Devices for separating materials from a host fluid are disclosed. The devices include an acoustic chamber having an inlet and an outlet. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps the materials and permits a continuous separation of the materials from the host fluid. The materials and the host fluid can thus be separately collected. Multiple sets of trapping lines are generated by the acoustic standing wave, and the transducer is oriented to minimize cross-sectional area for straight vertical channels between the trapping lines.
摘要翻译： 公开了用于从主体流体分离材料的装置。 这些装置包括具有入口和出口的声学室。 超声波换能器和反射器在声学室中产生多维声驻波，捕获材料并允许材料与主体流体的连续分离。 因此，可以分别收集材料和主体流体。 通过声驻波产生多组捕获线，并且换能器被定向成使捕获线之间的直立垂直通道的横截面面积最小化。
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公开(公告)号：US11377651B2
公开(公告)日：2022-07-05
申请号：US15916270
申请日：2018-03-08
发明人： Bart Lipkens , Rui Tostoes , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Walter M. Presz, Jr. , Benjamin Ross-Johnsrud , Goutam Ghoshal , Kedar Chitale
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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公开(公告)号：US10814253B2
公开(公告)日：2020-10-27
申请号：US15690263
申请日：2017-08-29
发明人： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US10662404B2
公开(公告)日：2020-05-26
申请号：US15475469
申请日：2017-03-31
发明人： Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC分类号： B01D17/06 , C12M1/00 , C12M1/42 , C12M1/26 , C12M1/02 , B06B1/06 , B01D17/04 , B01D21/28 , C12M1/06 , C12P21/02
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号：US10350514B2
公开(公告)日：2019-07-16
申请号：US15621691
申请日：2017-06-13
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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公开(公告)号：US09745548B2
公开(公告)日：2017-08-29
申请号：US15420073
申请日：2017-01-30
发明人： Bart Lipkens , Rudolf Gilmanshin , Louis Masi , Benjamin Ross-Johnsrud , Erik Miller , Walter M. Presz, Jr. , Thomas J. Kennedy, III
IPC分类号： B01D37/00 , C12M1/00 , B01D21/28 , C12M1/34 , G10K15/04 , G10K9/122 , C12M1/26 , C12N13/00 , C07K1/14
CPC分类号： C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C07K1/14 , C12M29/10 , C12M29/18 , C12M33/08 , C12M35/04 , C12M41/12 , C12M47/10 , C12N13/00 , G10K9/122 , G10K15/00 , G10K15/043
摘要： Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.
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公开(公告)号：US09744483B2
公开(公告)日：2017-08-29
申请号：US15249129
申请日：2016-08-26
发明人： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
CPC分类号： B01D21/283 , B01D21/0042 , B01D21/0045 , B01D21/0087 , B01D21/2422 , B06B1/06 , C02F1/36 , C12M47/02
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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