公开(公告)号：US20240260865A1

公开(公告)日：2024-08-08

申请号：US18623971

申请日：2024-04-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Dvin I. ADALIAN ,  Peter PETILLO ,  Muhammad Musab JILANI ,  Xiomara L. MADERO ,  Deepan KISHORE KUMAR

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1459 ,  C12N9/02 ,  C12N11/02 ,  C12N11/14 ,  G01N27/327

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1459 ,  C12N9/0004 ,  C12N11/02 ,  C12N11/14 ,  G01N27/3272 ,  C12Y101/01001 ,  C12Y101/03003 ,  C12Y101/03005 ,  C12Y101/03007 ,  C12Y101/03008 ,  C12Y101/0301 ,  C12Y101/03011 ,  C12Y101/03012 ,  C12Y101/03015 ,  C12Y101/03016 ,  C12Y101/03018 ,  C12Y101/03019 ,  C12Y101/0302 ,  C12Y101/03023 ,  C12Y101/03027 ,  C12Y101/03029 ,  C12Y101/0303 ,  C12Y101/03037 ,  C12Y101/03038 ,  C12Y101/0304 ,  C12Y101/03041

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US20230121718A1

公开(公告)日：2023-04-20

申请号：US18046737

申请日：2022-10-14

Applicant: California Institute of Technology ,  Gottfried Wilhelm Leibniz Universität Hannover ,  Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Inventor： Oliver PLETTENBURG ,  Christin AHLBRECHT ,  Dvin ADALIAN ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Samson CHEN ,  Muhammad Musab JILANI

IPC: G01N27/327

Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.

公开(公告)号：US20220071529A1

公开(公告)日：2022-03-10

申请号：US17405943

申请日：2021-08-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dvin ADALIAN ,  Samson CHEN ,  Muhammad M. JILANI ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Richard SMITH

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：US20190307378A1

公开(公告)日：2019-10-10

申请号：US16191357

申请日：2018-11-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dvin ADALIAN ,  Samson CHEN ,  Muhammad M. JILANI ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Richard SMITH

IPC: A61B5/1486 ,  A61B5/145

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：US20240148248A1

公开(公告)日：2024-05-09

申请号：US18307361

申请日：2023-04-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Peter A PETILLO ,  Samson CHEN ,  Azita EMAMI

IPC: A61B5/00 ,  A01K1/03 ,  A01K11/00 ,  A01K29/00 ,  A61B5/11 ,  H04B5/24

CPC classification number: A61B5/002 ,  A01K1/031 ,  A01K11/006 ,  A01K29/00 ,  A61B5/1113 ,  H04B5/24 ,  A61B5/01

Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.

公开(公告)号：US20240125819A1

公开(公告)日：2024-04-18

申请号：US18377547

申请日：2023-10-06

Applicant: California Institute of Technology ,  TotalEnergies OneTech

Inventor： Axel Scherer ,  John Richard Ordonez-Varela ,  Samson CHEN ,  Pasha RESHETIKHIN

IPC: G01R15/20 ,  G01R21/06

CPC classification number: G01R15/20 ,  G01R21/06

Abstract: The present disclosure is directed toward systems and methods for measuring electric current in a multi-wire cable, as well as the apparent and real power associated with an electrical load connected to the cable. A probe comprising an array of small form-factor, high-speed magnetometers is operatively coupled with the cable such that the magnetometers partially surround the cable. Each magnetometer detects the composite magnetic field at its location, and this plurality of measurements is used to generate a magnetic-field map. The contributions of the current flow in each wire are identified by deconvolving the magnetic-field map, enabling their locations to be determined and monitoring of the current and power flow. A sensor included in the probe is used to determine the phase of the applied voltage. The phase difference between the voltage and current is then used to determine the real power dissipation of the load.

公开(公告)号：US20210322300A1

公开(公告)日：2021-10-21

申请号：US17321296

申请日：2021-05-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Richard Daniel SMITH, JR.

IPC: A61K9/00 ,  A61B5/145 ,  A61B5/00 ,  A61J1/14

Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

公开(公告)号：US20190090797A1

公开(公告)日：2019-03-28

申请号：US16144174

申请日：2018-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER

IPC: A61B5/1486 ,  G01N27/30 ,  G01N27/419 ,  A61B5/1459

Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.

公开(公告)号：US20140100102A1

公开(公告)日：2014-04-10

申请号：US14048735

申请日：2013-10-08

Applicant: California Institute Of Technology

Inventor： Aditya RAJAGOPAL ,  Emil P. KARTALOV ,  Carl J. ALLENDORPH ,  Axel SCHERER ,  Samson CHEN

IPC: C12M1/00

CPC classification number: C12M47/06

Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.

Abstract translation: 公开了基于离心的分子分析方法和装置。 离心机装置包括离心管和元件条，以产生磁场。 施加到具有生物分子的溶液中的珠的磁剪切力允许执行不同的分析技术，例如用于PCR的裂解和样品制备。