公开(公告)号：US20210277004A1

公开(公告)日：2021-09-09

申请号：US17254914

申请日：2019-06-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Scott W. Martin ,  Ivar M. Mcdonald ,  Stephen E. Mercer ,  Richard E. Olson ,  Upender Velaparthi ,  Michael Wichroski ,  Xiaofan Zheng

IPC: C07D471/04 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US10517870B2

公开(公告)日：2019-12-31

申请号：US15747218

申请日：2016-07-28

Applicant: Bristol-Myers Squibb Company

Inventor： Xiaojun Zhang ,  Xiaofan Zheng ,  Louis S. Chupak

IPC: A61K31/498 ,  C07D241/44 ,  A61P7/02 ,  A61P9/10 ,  A61P31/20

Abstract: Disclosed is a compound of Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein one R3 is H and the other R3 is an aryl group substituted with zero to 3 R3a; and R1, R2, and R3a are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors for the inhibition or prevention of platelet aggregation, and the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder. Also disclosed are methods of using such compounds for the treatment of human papillomavirus. Additionally, pharmaceutical compositions comprising at least one compound of Formula (I) are disclosed.

公开(公告)号：US11964973B2

公开(公告)日：2024-04-23

申请号：US17130022

申请日：2020-12-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Robert G. Gentles ,  Upender Velaparthi ,  Min Ding ,  Richard E. Olson ,  Scott W. Martin ,  Saumya Roy ,  Prasada Rao Jalagam ,  Jayakumar Sankara Warrier ,  Louis S. Chupak ,  Denise Christine Grunenfelder

IPC: C07D471/04 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D401/04

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US10954238B1

公开(公告)日：2021-03-23

申请号：US16843024

申请日：2020-04-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Upender Velaparthi ,  Louis S. Chupak ,  Chetan Padmakar Darne ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Manjunatha Narayana Rao Kamble ,  Scott W. Martin ,  Raju Mannoori ,  Ivar M. McDonald ,  Richard E. Olson ,  Hasibur Rahaman ,  Prasada Rao Jalagam ,  Saumya Roy ,  Gopikishan Tonukunuru ,  Sivasudar Velaiah ,  Jayakumar Sankara Warrier ,  Xiaofan Zheng ,  John S. Tokarski ,  Bireshwar Dasgupta ,  Kotha Rathnakar Reddy ,  Thiruvenkadam Raja

IPC: C07D403/04 ,  C07D487/04 ,  A61K31/196 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US09850225B2

公开(公告)日：2017-12-26

申请号：US14681772

申请日：2015-04-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Min Ding ,  Scott W. Martin ,  Xiaofan Zheng ,  Piyasena Hewawasam ,  Timothy P. Connolly ,  Ningning Xu ,  Kap-Sun Yeung ,  Juliang Zhu ,  David R. Langley ,  Paul Michael Scola

IPC: C07D319/18 ,  A61K31/357 ,  C07D405/12 ,  A61K31/453 ,  C07D405/14 ,  A61K31/4545 ,  C07D217/16 ,  A61K31/472 ,  C07D413/12 ,  A61K31/5377 ,  C07D417/12 ,  A61K31/541 ,  A61K31/496 ,  A61K45/06 ,  C07C255/54 ,  C07D215/14 ,  C07D215/18 ,  C07D231/56 ,  C07D405/04 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07C271/28 ,  C07C317/22 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  A61K31/165 ,  A61K31/277 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/505

CPC classification number: C07D319/18 ,  A61K31/165 ,  A61K31/277 ,  A61K31/357 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D217/16 ,  C07D231/56 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20150291549A1

公开(公告)日：2015-10-15

申请号：US14681772

申请日：2015-04-08

Applicant: Bristol-Myers Squibb Company

Inventor： Louis S. Chupak ,  Min Ding ,  Scott W. Martin ,  Xiaofan Zheng ,  Piyasena Hewawasam ,  Timothy P. Connolly ,  Ningning Xu ,  Kap-Sun Yeung ,  Juliang Zhu ,  David R. Langley ,  Daniel J. Tenney ,  Paul Michael Scola

IPC: C07D319/18 ,  C07D405/12 ,  A61K31/453 ,  C07D405/14 ,  A61K31/4545 ,  A61K45/06 ,  A61K31/472 ,  C07D413/12 ,  A61K31/5377 ,  C07D417/12 ,  A61K31/541 ,  A61K31/496 ,  A61K31/357 ,  C07D217/16

CPC classification number: C07D319/18 ,  A61K31/165 ,  A61K31/277 ,  A61K31/357 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D217/16 ,  C07D231/56 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract translation: 本公开一般涉及可用作免疫调节剂的化合物。 本文提供的化合物，包含这些化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。