Invention Application
- Patent Title: NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS
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Application No.: US17254914Application Date: 2019-06-26
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Publication No.: US20210277004A1Publication Date: 2021-09-09
- Inventor: Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- International Application: PCT/US2019/039131 WO 20190626
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61P35/00

Abstract:
Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
Public/Granted literature
- US11866430B2 Naphthyridinone compounds useful as T cell activators Public/Granted day:2024-01-09
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