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公开(公告)号：US07139666B2
公开(公告)日：2006-11-21
申请号：US10356349
申请日：2003-01-31
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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公开(公告)号：US20060177910A1
公开(公告)日：2006-08-10
申请号：US11402542
申请日：2006-04-11
IPC分类号： C12P19/28
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US06947849B2
公开(公告)日：2005-09-20
申请号：US10356349
申请日：2003-01-31
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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公开(公告)号：US08609632B2
公开(公告)日：2013-12-17
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , A61K31/715 , A01N43/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US08470603B2
公开(公告)日：2013-06-25
申请号：US12298591
申请日：2007-04-30
CPC分类号： G01N33/9493 , A61K38/02 , G01N33/15 , G01N33/68 , G01N33/6806 , G01N33/6821 , G01N33/6848 , Y10T436/24 , Y10T436/25125
摘要： The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
摘要翻译： 目前公开的主题提供了用于评估和表征肽，肽混合物和多肽混合物的方法。 更具体地，本发明公开的主题提供了用于评估或表征包含谷氨酸，丙氨酸，酪氨酸和赖氨酸的复合肽或多肽混合物的方法，例如共聚物-1或乙酸格拉默，包括但不限于鉴定， 分离，定量和纯化具有二乙基酰胺基团而不是C末端存在的羧基的氨基酸，肽，多肽及其组合。 目前公开的方法可以用于确定在C末端具有二乙酰胺基团的多肽的摩尔百分比，并且可以用于评估一种多肽混合物的样品的一种或多种性质，与一种或多种性质的 不同样品的多肽混合物。
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公开(公告)号：US08435799B2
公开(公告)日：2013-05-07
申请号：US12203574
申请日：2008-09-03
申请人： David Schrier , Nur Sibel Gunay , Megan Sucato , Stephen Smith , Zachary Shriver
发明人： David Schrier , Nur Sibel Gunay , Megan Sucato , Stephen Smith , Zachary Shriver
IPC分类号： G01N30/02
CPC分类号： G01N30/02 , A61K31/727 , G01N2030/8836 , G06Q10/0635 , B01D15/363
摘要： The disclosure features methods of analyzing preparations of heparin, and materials derived from heparin using strong anion exchange high performance liquid chromatography (SAX-HPLC).
摘要翻译： 本公开的特征是使用强阴离子交换高效液相色谱（SAX-HPLC）分析肝素制剂和肝素衍生物质的方法。
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公开(公告)号：US20130017565A1
公开(公告)日：2013-01-17
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US08329391B2
公开(公告)日：2012-12-11
申请号：US12408058
申请日：2009-03-20
申请人： Xiangping Zhu , Zachary Shriver , Yanjie Jiang , Corinne Bauer , James Eric Anderson , Peter James Ahern
发明人： Xiangping Zhu , Zachary Shriver , Yanjie Jiang , Corinne Bauer , James Eric Anderson , Peter James Ahern
CPC分类号： C12Q1/37 , A61K31/785 , A61K38/02 , C07K14/001 , C08G69/10 , C12Y304/19003 , G01N33/6812
摘要： Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.
摘要翻译： 描述了分析，选择，表征或分类共聚物（例如醋酸格拉默）的组合物的方法。 该方法需要对组合物中的焦谷氨酸进行分析，并且在一些方法中，将组合物中存在的焦谷氨酸的量与参考标准进行比较。 在一些情况下，该方法需要用焦谷氨酸氨基肽酶处理共聚物以切割N-末端的热 - 谷氨酸残基。
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公开(公告)号：US20110288046A1
公开(公告)日：2011-11-24
申请号：US13086054
申请日：2011-04-13
IPC分类号： A61K31/727 , A61P7/02 , G01N30/02 , C08B37/10
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译： 本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。 特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法进行了描述。
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公开(公告)号：US20110257032A1
公开(公告)日：2011-10-20
申请号：US13087332
申请日：2011-04-14
申请人： Ram Sasisekharan , Karthik Viswanathan , Udayanath Aich , Rahul Raman , Zachary Shriver , Ido Bachelet
发明人： Ram Sasisekharan , Karthik Viswanathan , Udayanath Aich , Rahul Raman , Zachary Shriver , Ido Bachelet
CPC分类号： G01N33/56983 , C07B2200/11 , C40B40/12 , G01N2333/11 , G01N2400/12 , Y02A50/59
摘要： The present invention provides methods and systems for functionally analyzing glycans and their interaction partners. Among other things, the invention provides modular glycan arrays in which different glycan populations are associated with different discrete solid phase particles. Provided arrays offer many advantages over available systems for assessing glycan binding interactions.
摘要翻译： 本发明提供用于功能分析聚糖及其相互作用配偶体的方法和系统。 除此之外，本发明提供了模块化聚糖阵列，其中不同的聚糖群体与不同的离散固相颗粒相关联。 提供的阵列比用于评估聚糖结合相互作用的可用系统提供了许多优点。
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