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公开(公告)号：US11511252B2
公开(公告)日：2022-11-29
申请号：US16590093
申请日：2019-10-01
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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公开(公告)号：US20240342424A1
公开(公告)日：2024-10-17
申请号：US18421265
申请日：2024-01-24
Applicant: VERO Biotech Inc.
Inventor： David H. FINE
IPC: A61M16/12 , A61K31/655 , A61K33/00 , A61K47/02 , A61M5/165 , A61M15/00 , A61M15/08 , A61M16/10 , A61M35/00 , A61K9/00 , A61K9/70 , A61M5/00
CPC classification number: A61M16/12 , A61K31/655 , A61K33/00 , A61K47/02 , A61M5/165 , A61M15/00 , A61M15/08 , A61M15/085 , A61M16/105 , A61M35/006 , A61K9/0043 , A61K9/0073 , A61K9/7023 , A61M2005/006 , A61M2202/0275 , A61M2205/75
Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.
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公开(公告)号：US20240131292A1
公开(公告)日：2024-04-25
申请号：US18491463
申请日：2023-10-19
Applicant: VERO BIOTECH INC.
Inventor： John MAYNARD , Jason MOLINARI , Lucas G. GAMERO
CPC classification number: A61M16/12 , A61M16/0003 , A61M16/024 , A61M2202/0275
Abstract: Disclosed herein is a system for delivering a nitric oxide to a subject, wherein the system comprises: (a) a nitric oxide injection line configured to inject a first gas at an injection point into a breathing conduit comprising a breathing gas, wherein the first gas comprises a first amount of nitric oxide; (b) a sampling line configured to sample a second gas comprising a second amount of nitric oxide and the breathing gas at a sampling location between the injection point of the first gas and a subject and (c) a feedback-loop controller that is in communication with: (i) a nitric oxide set-point controller configured to set a nitric oxide set-point amount; (ii) a source configured to provide a third gas having a third amount of nitric oxide; and (iii) at least one sensor configured to measure the second amount of nitric oxide in the sampling line.
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公开(公告)号：US11779725B2
公开(公告)日：2023-10-10
申请号：US16988185
申请日：2020-08-07
Applicant: VERO Biotech Inc.
Inventor： Barry N. Gellman , Eddie Tajudeen , Lucas Gamero , Joshua Hopkins , Edward E. A. Bromberg , Ryan Denton , Bryan J. Johnson , David Fine
CPC classification number: A61M16/12 , C01B21/24 , A61M16/107 , A61M2016/003 , A61M2016/0027 , A61M2202/0275 , A61M2205/12
Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4 activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.
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公开(公告)号：US11754538B1
公开(公告)日：2023-09-12
申请号：US16511928
申请日：2019-07-15
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , Edward Bromberg , Thorsten Schmidt , Ryan Denton , Lucas G. Gamero , Gregory Vasquez
IPC: G01N33/00 , G01N1/38 , G01N27/41 , A61M16/10 , A61M16/12 , A61M16/00 , C01B21/20 , C01B21/24 , G01N27/416
CPC classification number: G01N33/0006 , A61M16/024 , A61M16/109 , A61M16/125 , C01B21/20 , C01B21/24 , G01N1/38 , G01N27/4162 , G01N33/0037 , A61M2202/0275 , A61M2205/702 , G01N27/4163 , Y10T436/100833 , Y10T436/102499
Abstract: A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO2 to check and calibrate NO and NO2 sensors.
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Patent Agency Ranking
公开(公告)号：US20230077727A1
公开(公告)日：2023-03-16
申请号：US17727489
申请日：2022-04-22
Applicant: VERO Biotech Inc.
Inventor： David H. FINE , Gregory VASQUEZ , David P. ROUNBEHLER
IPC: C01B21/32 , A61K33/00 , C01B21/24 , A61D7/04 , A61M16/12 , A61M16/00 , A61M16/10 , A61M16/16 , G01N27/416
Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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公开(公告)号：US20220409843A1
公开(公告)日：2022-12-29
申请号：US17862026
申请日：2022-07-11
Applicant: VERO Biotech Inc.
Inventor： David P. ROUNBEHLER , David H. FINE
Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
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公开(公告)号：US12186486B2
公开(公告)日：2025-01-07
申请号：US17025298
申请日：2020-09-18
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , Gregory Vasquez , Bryan Johnson
IPC: A61M16/10 , A61K31/198 , A61K33/00 , A61M16/00 , A61M16/06
Abstract: A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.
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公开(公告)号：US12059661B2
公开(公告)日：2024-08-13
申请号：US18059309
申请日：2022-11-28
Applicant: VERO Biotech Inc.
Inventor： David Fine , David Rounbehler , Gregory Vasquez , Bryan Johnson
CPC classification number: B01J12/007 , A61K33/00 , A61M16/10 , A61M16/122 , A62B7/08 , C01B21/24 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2202/0275 , A61M2205/07 , A61M2205/12
Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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公开(公告)号：US20240094175A1
公开(公告)日：2024-03-21
申请号：US18338892
申请日：2023-06-21
Applicant: VERO Biotech Inc.
Inventor： David H. FINE , Edward BROMBERG , Thorsten SCHMIDT , Ryan DENTON , Lucas G. GAMERO , Gregory VASQUEZ
CPC classification number: G01N33/0006 , A61M16/024 , A61M16/109 , A61M16/125 , C01B21/20 , C01B21/24 , G01N1/38 , G01N27/4162 , G01N33/0037 , A61M2202/0275 , A61M2205/702 , G01N27/4163 , Y10T436/100833 , Y10T436/102499
Abstract: A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO2 to check and calibrate NO and NO2 sensors.
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