公开(公告)号：US20130109705A1

公开(公告)日：2013-05-02

申请号：US13699077

申请日：2011-05-19

Applicant: Tona M. Gilmer ,  Rakesh Kumar

Inventor： Tona M. Gilmer ,  Rakesh Kumar

IPC: A61K31/519 ,  A61K31/517

CPC classification number: A61K31/519 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/517 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, or a pharmaceutically acceptable hydrate and/or salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3-氯-4 - [（3-氟苄基）氧基]苯基} -6- [5 - （{[2-（甲磺酰基）乙基]氨基 }甲基）-2-呋喃基] -4-喹唑啉胺或其药学上可接受的水合物和/或盐和N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基） -2,4,7-三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物 对有需要的人。

公开(公告)号：US08388877B2

公开(公告)日：2013-03-05

申请号：US12975463

申请日：2010-12-22

Applicant: Rakesh Kumar Gupta ,  Scott Ellery George ,  Daniel William Klosiewicz ,  Kab Sik Seo ,  Coralie McKenna Fleenor ,  Allen Lynn Crain

Inventor： Rakesh Kumar Gupta ,  Scott Ellery George ,  Daniel William Klosiewicz ,  Kab Sik Seo ,  Coralie McKenna Fleenor ,  Allen Lynn Crain

IPC: D01D5/34 ,  D01F6/62

CPC classification number: D04B1/16 ,  D01F8/14 ,  D02J1/22 ,  D03D15/00 ,  D04H1/4291 ,  D04H1/4334 ,  D04H1/435 ,  D04H1/4382 ,  D04H1/4391 ,  D04H3/10 ,  Y10T428/249921 ,  Y10T428/249938 ,  Y10T428/2913 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T442/2525 ,  Y10T442/2861 ,  Y10T442/30 ,  Y10T442/3146 ,  Y10T442/3154 ,  Y10T442/3163 ,  Y10T442/60 ,  Y10T442/637 ,  Y10T442/638 ,  Y10T442/64 ,  Y10T442/641 ,  Y10T442/68 ,  Y10T442/681 ,  Y10T442/689 ,  Y10T442/69

Abstract: Disclosed are multicomponent fibers derived from a blend of a sulfopolyester with a water non-dispersible polymer wherein the as-spun denier is less than about 6 and wherein the water dispersible sulfopolyester exhibits a melt viscosity of less than 12,000 poise measured at 240° C. at a strain rate of 1 rad/sec, and wherein the sulfopolyester comprising less than about 25 mole % of residues of at least one sulfomonomer, based on the total moles of diacid or diol residues. The multicomponent fiber is capable of being drawn at a relatively high fiber speed, particularly at least about 2000 m/min, and may be used to produce microdenier fibers. Fibrous articles may be produced from the multicomponent fibers and microdenier fibers. Also disclosed is a process for multicomponent fibers, nonwoven fabrics, and microdenier webs.

Abstract translation: 公开了衍生自磺基聚酯与水不可分散聚合物的共混物的多组分纤维，其中初纺旦尼尔小于约6，并且其中水分散性磺基聚酯在240℃下测量的熔体粘度小于12,000泊。 以1rad / sec的应变速率，其中基于二酸或二醇残基的总摩尔数，磺基聚酯包含少于约25摩尔％的至少一种磺基单体的残基。 多组分纤维能够以相对高的纤维速度，特别是至少约2000m / min的速度拉伸，并且可以用于生产微旦尼尔纤维。 纤维制品可以由多组分纤维和微旦尼尔纤维生产。 还公开了一种多组分纤维，非织造织物和微米网的方法。

公开(公告)号：US20130048018A1

公开(公告)日：2013-02-28

申请号：US13580423

申请日：2011-02-21

Applicant: Christopher Wargo ,  Rakesh Kumar Singh ,  David Trio ,  Eric McNamara

Inventor： Christopher Wargo ,  Rakesh Kumar Singh ,  David Trio ,  Eric McNamara

IPC: B08B1/04

CPC classification number: H01L21/67046

Abstract: Embodiments of the invention include a CMP brush that has a combination of central nodules at an inner region of the brush and one or more edge nodules at an end region of the brush where the central nodules and edge nodules are in a staggered or matched arrangement with each other and an upper surface of each edge nodule on the brush has the same or a greater contact area than an upper surface of a central nodule. The area of contact of the upper surface of each edge nodule with the substrate edge region is the same or greater than the area of contact of the upper surface of a central nodule with the substrate center region.

Abstract translation: 本发明的实施例包括CMP刷，其具有在刷子的内部区域处的中心结节和在刷子的端部区域处的一个或多个边缘结节的组合，其中中心结节和边缘结节与交错或匹配布置具有交错或匹配的布置， 彼此和刷子上的每个边缘结节的上表面具有与中心结节的上表面相同或更大的接触面积。 每个边缘结节的上表面与基底边缘区域的接触面积与中心结节的上表面与基底中心区域的接触面积相同或更大。

公开(公告)号：US20120322817A1

公开(公告)日：2012-12-20

申请号：US13497576

申请日：2010-09-23

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renee Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renee Morris ,  Sylvie Laquerre

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K9/145 ,  A61K9/2054 ,  A61K31/4155 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）-6,8-二甲基-2,4,7- 三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物，和N - {（1S）-2 - 氨基-1 - [（3,4-二氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的 其盐，需要其的人。

公开(公告)号：US20120283278A1

公开(公告)日：2012-11-08

申请号：US13497580

申请日：2010-09-23

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4155 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）-6,8-二甲基-2,4,7- 三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物，和N - {（1S）-2 - 氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-噻吩甲酰胺或其药学上可接受的盐 ，对有需要的人。

公开(公告)号：US20120269058A1

公开(公告)日：2012-10-25

申请号：US13538393

申请日：2012-06-29

Applicant: Kadangode K. Ramakrishnan ,  Rakesh Kumar Sinha ,  Ajay Kumar Todimala

Inventor： Kadangode K. Ramakrishnan ,  Rakesh Kumar Sinha ,  Ajay Kumar Todimala

IPC: H04L12/24

CPC classification number: H04L41/0816 ,  H04L41/06

Abstract: A second link in a network is reconfigured after failure of a first link, so that multiple-link failures may be survived. After receipt of an OSPF link state advertisement (LSA) indicating use of a backup path bl after the failure of link l, new backup paths are determined for each impacted link (x,y) that has a backup path sharing one or more links with the backup path bl. The new backup paths are computed while ignoring the failed link l, the impacted link (x,y), and links common to the backup paths b(x,y) and bl. The LSA protocol is modified to accommodate information used in determining whether a link is an impacted link.

Abstract translation: 网络中的第二个链路在第一个链路发生故障后被重新配置，从而多链路故障可能会被存活。 在收到指示在链路l故障之后使用备份路径b1的OSPF链路状态通告（LSA）之后，为每个受影响的链路（x，y）确定新的备份路径，该备份路径具有共享一个或多个链路的备份路径 备份路径bl。 计算新的备份路径，同时忽略故障链路l，受影响的链路（x，y）以及备份路径b（x，y）和bl共同的链路。 修改LSA协议以适应用于确定链路是否是受影响链路的信息。

公开(公告)号：US08289390B2

公开(公告)日：2012-10-16

申请号：US11192486

申请日：2005-07-28

Applicant: Manoj Aggarwal ,  Keith Hanna ,  Harpreet Sawhney ,  Vincent Paragano ,  Rakesh Kumar ,  Supun Samarasekera ,  Aydin Arpa ,  Thomas Germano ,  Tao Zhao ,  David Kalokitis ,  David R. Patterson

Inventor： Manoj Aggarwal ,  Keith Hanna ,  Harpreet Sawhney ,  Vincent Paragano ,  Rakesh Kumar ,  Supun Samarasekera ,  Aydin Arpa ,  Thomas Germano ,  Tao Zhao ,  David Kalokitis ,  David R. Patterson

IPC: H04N7/18

CPC classification number: G01S3/7864 ,  G06K9/00771 ,  G06K9/32 ,  G06K9/6289 ,  G06T7/246 ,  G06T7/285 ,  G06T7/292 ,  G06T7/70 ,  G06T2207/30232 ,  G06T2207/30241 ,  G08B13/19608 ,  G08B13/19641 ,  G08B13/19645 ,  G08B13/19682 ,  H04N5/2224 ,  H04N5/76 ,  H04N13/204 ,  H04N13/239 ,  H04N13/243 ,  H04N2013/0081 ,  H04N2013/0085

Abstract: A sentient system combines detection, tracking, and immersive visualization of a cluttered and crowded environment, such as an office building, terminal, or other enclosed site using a network of stereo cameras. A guard monitors the site using a live 3D model, which is updated from different directions using the multiple video streams. As a person moves within the view of a camera, the system detects its motion and tracks the person's path, it hands off the track to the next camera when the person goes out of that camera's view. Multiple people can be tracked simultaneously both within and across cameras, with each track shown on a map display. The track system includes a track map browser that displays the tracks of all moving objects as well as a history of recent tracks and a video flashlight viewer that displays live immersive video of any person that is being tracked.

Abstract translation: 有声系统使用立体相机网络将杂乱无章的环境（例如办公楼，终端或其他封闭场所）的检测，跟踪和沉浸式可视化相结合。 守卫使用实时3D模型监视站点，该模型使用多个视频流从不同方向更新。 当一个人在相机的视野内移动时，系统会检测到其运动并跟踪人的路径，当人离开该相机视图时，它将该轨迹移离下一个相机。 可以在摄像机内和摄像机上同时跟踪多个人，每个轨道显示在地图显示上。 轨道系统包括轨迹映射浏览器，其显示所有运动对象的轨迹以及最近轨道的历史以及显示正在被跟踪的任何人的现场沉浸式视频的视频手电筒观看者。

公开(公告)号：US20120241901A1

公开(公告)日：2012-09-27

申请号：US13052134

申请日：2011-03-21

Applicant: Rama Krishna KOTLANKA ,  Rakesh KUMAR ,  Premachandran CHIRAYARIKATHUVEEDU SANKARAPILLAI ,  Pradeep Ramachandramurthy YELEHANKA

Inventor： Rama Krishna KOTLANKA ,  Rakesh KUMAR ,  Premachandran CHIRAYARIKATHUVEEDU SANKARAPILLAI ,  Pradeep Ramachandramurthy YELEHANKA

IPC: H01L23/48 ,  H01L21/768 ,  H01L21/76

CPC classification number: H01L21/76898 ,  B81B7/007 ,  B81B2207/095 ,  B81B2207/096 ,  H01L23/147 ,  H01L23/481 ,  H01L23/49827 ,  H01L2224/16225 ,  H01L2924/01322 ,  H01L2924/1461 ,  H01L2924/15311 ,  H01L2924/00

Abstract: A method for forming a device is disclosed. A support substrate having first and second major surfaces is provided. An interconnect is formed through the first and second major surfaces in the support substrate. The interconnect has first and second portions. The first portion extends from one of the first or second major surfaces and the second portion extends from the other of the first and second major surfaces. The interconnect includes a partial via plug having a conductive material in a first portion of the interconnect. The via plug has a bottom at about an interface of the first and second portions. The second portion of the interconnect is heavily doped with dopants of a first polarity type.

Abstract translation: 公开了一种用于形成装置的方法。 提供具有第一和第二主表面的支撑基板。 通过支撑衬底中的第一和第二主表面形成互连。 互连具有第一和第二部分。 第一部分从第一或第二主表面中的一个延伸，第二部分从第一和第二主表面中的另一个延伸。 互连包括在互连的第一部分中具有导电材料的部分通孔塞。 通孔塞在第一和第二部分的界面的大约一个界面处具有底部。 互连的第二部分用第一极性类型的掺杂剂重掺杂。

公开(公告)号：US08257628B2

公开(公告)日：2012-09-04

申请号：US12975456

申请日：2010-12-22

Applicant: Rakesh Kumar Gupta ,  Scott Ellery George ,  Daniel William Klosiewicz ,  Kab Sik Seo ,  Coralie McKenna Fleenor ,  Allen Lynn Crain

Inventor： Rakesh Kumar Gupta ,  Scott Ellery George ,  Daniel William Klosiewicz ,  Kab Sik Seo ,  Coralie McKenna Fleenor ,  Allen Lynn Crain

IPC: D01D5/34 ,  D01D5/36 ,  D01F1/04 ,  D01F1/10 ,  D01F8/14

CPC classification number: D04B1/16 ,  D01F8/14 ,  D02J1/22 ,  D03D15/00 ,  D04H1/4291 ,  D04H1/4334 ,  D04H1/435 ,  D04H1/4382 ,  D04H1/4391 ,  D04H3/10 ,  Y10T428/249921 ,  Y10T428/249938 ,  Y10T428/2913 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T442/2525 ,  Y10T442/2861 ,  Y10T442/30 ,  Y10T442/3146 ,  Y10T442/3154 ,  Y10T442/3163 ,  Y10T442/60 ,  Y10T442/637 ,  Y10T442/638 ,  Y10T442/64 ,  Y10T442/641 ,  Y10T442/68 ,  Y10T442/681 ,  Y10T442/689 ,  Y10T442/69

Abstract: Disclosed are multicomponent fibers derived from a blend of a sulfopolyester with a water non-dispersible polymer wherein the as-spun denier is less than about 6 and wherein the water dispersible sulfopolyester exhibits a melt viscosity of less than 12,000 poise measured at 240° C. at a strain rate of 1 rad/sec, and wherein the sulfopolyester comprising less than about 25 mole % of residues of at least one sulfomonomer, based on the total moles of diacid or diol residues. The multicomponent fiber is capable of being drawn at a relatively high fiber speed, particularly at least about 2000 m/min, and may be used to produce microdenier fibers. Fibrous articles may be produced from the multicomponent fibers and microdenier fibers. Also disclosed is a process for multicomponent fibers, nonwoven fabrics, and microdenier webs.

Abstract translation: 公开了衍生自磺基聚酯与水不可分散聚合物的共混物的多组分纤维，其中初纺旦尼尔小于约6，并且其中水分散性磺基聚酯在240℃下测量的熔体粘度小于12,000泊。 以1rad / sec的应变速率，其中基于二酸或二醇残基的总摩尔数，磺基聚酯包含少于约25摩尔％的至少一种磺基单体的残基。 多组分纤维能够以相对高的纤维速度，特别是至少约2000m / min的速度拉伸，并且可以用于生产微旦尼尔纤维。 纤维制品可以由多组分纤维和微旦尼尔纤维生产。 还公开了一种多组分纤维，非织造织物和微米网的方法。

公开(公告)号：US20120196886A1

公开(公告)日：2012-08-02

申请号：US13500241

申请日：2010-10-08

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/506 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K31/4155 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基） 吡啶-2-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐和N - {（1S）-2-氨基-1 - [（3,4-二氟苯基）甲基]乙基} -4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的盐给有需要的人。