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    Method of bonding a bioglass to metal
    12.
    发明授权
    Method of bonding a bioglass to metal 失效
    将生物玻璃与金属接合的方法

    公开(公告)号：US4159358A

    公开(公告)日：1979-06-26

    申请号：US798671

    申请日：1977-05-19

    申请人： Larry L. Hench ,  Paul J. Buscemi

    发明人： Larry L. Hench ,  Paul J. Buscemi

    IPC分类号： C03C3/078 ,  A61C8/00 ,  A61F2/00 ,  A61F2/30 ,  A61K6/06 ,  A61L27/00 ,  A61L27/30 ,  A61L27/32 ,  C03C3/089 ,  C03C4/00 ,  C03C27/02 ,  C23D5/04 ,  B05D3/02

    CPC分类号： C03C4/0007 ,  A61C8/0012 ,  A61C8/0013 ,  A61F2/30767 ,  A61L27/306 ,  A61L27/32 ,  C03C27/02 ,  C23D5/04 ,  A61F2310/00796 ,  A61F2310/00928

    摘要： A method of bonding a bioglass layer to a metal substrate comprising heating the metal substrate having a roughened, oxidized surface to about a temperature at which the expansion of the metal is substantially equal to that of the bioglass at the temperature above which the thermal expansion of the bioglass is non-linear, immersing the heated metal surface in molten bioglass, the time of immersion being of such duration that the temperature of the metal does not rise substantially above the temperature to which it is heated, allowing the coated substrate to cool whereby the bioglass layer is bonded to the metal substrate by ion diffusion and thermo-mechanical stresses in the bioglass and metal layer are relieved at a substantially equal rate and the product produced by said process.

    摘要翻译： 一种将生物玻璃层粘合到金属基底上的方法，包括将具有粗糙化的氧化表面的金属基底加热至金属膨胀基本上等于生物玻璃膨胀的温度， 生物玻璃是非线性的，将加热的金属表面浸入熔融的生物玻璃中，浸渍时间使得金属的温度不会显着高于其被加热的温度，从而允许涂覆的基底冷却， 生物玻璃层通过离子扩散结合到金属基底上，生物玻璃和金属层中的热机械应力以基本上相等的速率释放，并且通过所述方法产生的产物。

    Tongue implant
    15.
    发明授权
    Tongue implant 有权
    舌植入

    公开(公告)号：US08381735B2

    公开(公告)日：2013-02-26

    申请号：US12586170

    申请日：2009-09-16

    申请人： Paul J. Buscemi ,  Kurt D. Krueger ,  Paula Bushendorf

    发明人： Paul J. Buscemi ,  Kurt D. Krueger ,  Paula Bushendorf

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566 ,  A61B2017/248

    摘要： A patient's obstructive sleep apnea is treated by identifying a patient with sleep apnea attributable at least in part to movement of a base of a tongue of the patient toward a pharyngeal wall of the patient. The tongue is stiffened by an implant sized to be placed within the tongue. A distal portion of the implant is sized to extend within the tongue from a first end near a mandibular-geniohyoid interface to a second end near a base of the tongue. A proximal portion is attached to the first end and adapted to be secured to a jaw bone of the patient following a period of healing after placement of the implant in the tongue.

    摘要翻译： 患者的阻塞性睡眠呼吸暂停通过识别至少部分地归因于患者的舌头的基部朝向患者的咽壁的移动而患有睡眠呼吸暂停的患者来治疗。 舌头由被放置在舌头内的植入物硬化。 植入物的远端部分的尺寸被设计成在舌下从第一端附近的下颌骨 - 基底膜界面延伸到靠近舌头基部的第二端。 近端部分附接到第一端并且适于在将植入物放置在舌头中之后经过愈合期后固定到患者的颚骨上。

    SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA
    16.
    发明申请
    SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 审中-公开
    用于治疗睡眠APNEA的系统和方法

    公开(公告)号：US20110308529A1

    公开(公告)日：2011-12-22

    申请号：US13113933

    申请日：2011-05-23

    申请人： Edward M. Gillis ,  John H. Shadduck ,  Csaba Truckai ,  Andrew Poutiatine ,  Paul J. Buscemi

    发明人： Edward M. Gillis ,  John H. Shadduck ,  Csaba Truckai ,  Andrew Poutiatine ,  Paul J. Buscemi

    IPC分类号： A61F5/56

    CPC分类号： A61F2/00 ,  A61F5/566 ,  A61F2210/0004

    摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has a V-shape with first and second elongated legs configured for implantation in airway-interface tissue. The first and second elongated legs are configured to apply tensile forces to the tissue. Methods of using such systems are also provided.

    摘要翻译： 一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，植入物本体具有V形，其中第一和第二细长腿构造成用于植入气道界面组织中。 第一和第二细长腿构造成对组织施加张力。 还提供了使用这种系统的方法。

    METHOD AND SYSTEM FOR MAMMALIAN JOINT RESURFACING
    18.
    发明申请
    METHOD AND SYSTEM FOR MAMMALIAN JOINT RESURFACING 有权
    MAMMALIAN JOINT RESURFACING的方法和系统

    公开(公告)号：US20080234820A1

    公开(公告)日：2008-09-25

    申请号：US11953203

    申请日：2007-12-10

    申请人： Jeffrey C. Felt ,  Mark A. Rydell ,  Paul J. Buscemi ,  Alexander Arsenyev ,  Christopher H. Porter

    发明人： Jeffrey C. Felt ,  Mark A. Rydell ,  Paul J. Buscemi ,  Alexander Arsenyev ,  Christopher H. Porter

    IPC分类号： A61F2/08 ,  A61F2/38 ,  A61F2/30

    CPC分类号： A61B17/562 ,  A61F2/30721 ,  A61F2/34 ,  A61F2/38 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/389 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61L27/18 ,  A61L2430/24 ,  C08G18/10 ,  C08G18/4854 ,  C08G18/61 ,  C08G18/69 ,  C08L75/04 ,  C08G18/32

    摘要： A method and system for the creation or modification of the wear surface of orthopedic joints, involving the preparation and use of one or more partially or fully preformed and procured components, adapted for insertion and placement into the body and at the joint site. In a preferred embodiment, component(s) can be partially cured and generally formed ex vivo and further and further formed in vivo at the joint site to enhance conformance and improve long term performance. In another embodiment, a preformed balloon or composite material can be inserted into the joint site and filled with a flowable biomaterial in situ to conform to the joint site. In yet another embodiment, the preformed component(s) can be fully cured and formed ex vivo and optionally further fitted and secured at the joint site. Preformed components can be sufficiently pliant to permit insertion through a minimally invasive portal, yet resilient enough to substantially assume, or tend towards, the desired form in vivo with additional forming there as needed.

    摘要翻译： 一种用于创建或修改整形外科关节磨损表面的方法和系统，涉及准备和使用一种或多种部分或完全预成型和采购的部件，适于插入和放置在身体和关节部位。 在一个优选的实施方案中，组分可以部分固化，并且通常在体外形式离体进一步形成并且在接合部位进一步形成，以增强一致性并改善长期性能。 在另一个实施方案中，预先形成的球囊或复合材料可以插入到关节部位中并且在原位填充可流动的生物材料以符合关节部位。 在另一个实施方案中，预成型组分可以完全固化并离体形成，并任选地进一步装配并固定在接头部位。 预成型组件可以足够柔顺以允许通过微创入口插入，但足够弹性足以基本上假设或倾向于体内所需的形式，并根据需要进一步形成。

    Method and system for mammalian joint resurfacing
    19.
    发明授权
    Method and system for mammalian joint resurfacing 有权
    哺乳动物关节表面置换的方法和系统

    公开(公告)号：US07320709B2

    公开(公告)日：2008-01-22

    申请号：US10722019

    申请日：2003-11-24

    申请人： Jeffrey C. Felt ,  Mark A. Rydell ,  Paul J. Buscemi ,  Alexander Arsenyev ,  Christopher H. Porter

    发明人： Jeffrey C. Felt ,  Mark A. Rydell ,  Paul J. Buscemi ,  Alexander Arsenyev ,  Christopher H. Porter

    IPC分类号： A61F2/38 ,  A61F2/28

    CPC分类号： A61B17/562 ,  A61F2/30721 ,  A61F2/34 ,  A61F2/38 ,  A61F2/3872 ,  A61F2/3877 ,  A61F2/389 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61L27/18 ,  A61L2430/24 ,  C08G18/10 ,  C08G18/4854 ,  C08G18/61 ,  C08G18/69 ,  C08L75/04 ,  C08G18/32

    摘要： A method and system for the creation or modification of the wear surface of orthopedic joints, involving the preparation and use of one or more partially or fully preformed and procured components, adapted for insertion and placement into the body and at the joint site. In a preferred embodiment, component(s) can be partially cured and generally formed ex vivo and further and further formed in vivo at the joint site to enhance conformance and improve long term performance. In another embodiment, a preformed balloon or composite material can be inserted into the joint site and filled with a flowable biomaterial in situ to conform to the joint site. In yet another embodiment, the preformed component(s) can be fully cured and formed ex vivo and optionally further fitted and secured at the joint site. Preformed components can be sufficiently pliant to permit insertion through a minimally invasive portal, yet resilient enough to substantially assume, or tend towards, the desired form in vivo with additional forming there as needed.

    摘要翻译： 一种用于创建或修改整形外科关节磨损表面的方法和系统，涉及准备和使用一种或多种部分或完全预成型和采购的部件，适于插入和放置在身体和关节部位。 在一个优选的实施方案中，组分可以部分固化，并且通常在体外形式离体进一步形成并且在接合部位进一步形成，以增强一致性并改善长期性能。 在另一个实施方案中，预先形成的球囊或复合材料可以插入到关节部位中并且在原位填充可流动的生物材料以符合关节部位。 在另一个实施方案中，预成型组分可以完全固化并离体形成，并任选地进一步装配并固定在接头部位。 预成型组件可以足够柔顺以允许通过微创入口插入，但足够弹性足以基本上假设或倾向于体内所需的形式，并根据需要进一步形成。

    Device and method for detection and treatment of syncope
    20.
    发明授权
    Device and method for detection and treatment of syncope 失效
    用于检测和治疗晕厥的装置和方法

    公开(公告)号：US6078834A

    公开(公告)日：2000-06-20

    申请号：US257566

    申请日：1999-02-25

    申请人： Keith G. Lurie ,  David Benditt ,  Stanislao F. Obino ,  Paul J. Buscemi

    发明人： Keith G. Lurie ,  David Benditt ,  Stanislao F. Obino ,  Paul J. Buscemi

    IPC分类号： A61M5/172 ,  A61N1/365 ,  A61M5/142

    CPC分类号： A61M5/1723 ,  A61N1/365 ,  A61N1/36571 ,  A61N1/36592

    摘要： The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.

    摘要翻译： 本文公开的本发明涉及用于检测和治疗晕厥的可植入医疗装置，其包括用于基于与晕厥发作相关的生理活动来确定晕厥的存在的算法，以及用于输注药物的装置。 药物输注治疗可以与起搏一起使用或与起搏组合使用。 该装置检测和使用的生理活动选自心率，心率变异性，QT间期，PR间期，压力，血流，迷走神经活动，温度，pH和AV传导时间的变化，呼吸频率 ，位置，运动及其组合。 可用于本发明的药物包括能够同时进行心内膜施用和治疗晕厥的药物组合物，例如包含β-受体阻滞剂的组合物。