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公开(公告)号：US20190147563A1
公开(公告)日：2019-05-16
申请号：US16249280
申请日：2019-01-16
Applicant: Sony Corporation , Japanese Foundation For Cancer Research
Inventor： Takeshi Ohashi
Abstract: Provided is an information processing apparatus including an image supply unit that supplies a plurality of input images showing corresponding objects to an image processing unit and obtains a plurality of object images as an image processed result from the image processing unit, and a display control unit that synchronously displays the plurality of object images that have been obtained. The object images are regions including the corresponding objects extracted from the plurality of input images, and orientations, positions, and sizes of the corresponding objects of the plurality of object images are unified.
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12.发明申请公开(公告)号：US20190094207A1
公开(公告)日：2019-03-28
申请号：US16079895
申请日：2017-02-27
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Toru Hirota , Yusuke Abe
IPC: G01N33/50 , C07K16/18 , G01N33/574 , G01N33/68
Abstract: The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1α, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.
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公开(公告)号：US20170010275A1
公开(公告)日：2017-01-12
申请号：US15113599
申请日：2015-01-23
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Kengo TAKEUCHI
IPC: G01N33/68 , G01N33/74 , G01N33/574 , G01N33/50 , C12Q1/68
CPC classification number: G01N33/689 , A61K31/713 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N33/574 , G01N33/57407 , G01N33/74 , G01N2333/71 , G01N2333/82
Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an FGFR3 fusion protein, or a fusion gene encoding the fusion protein, or a TACC3 fusion protein, or a fusion gene encoding the fusion protein, is detected in a sample derived from female genitalia obtained from a subject.
Abstract translation: 阐明了作为癌症的新型致病基因的多核苷酸，并且基于该发现，提供了用于检测多核苷酸或多核苷酸编码的多肽的方法。 用于检测的试剂盒和引物组; 筛选多肽抑制剂的方法; 以及用于治疗含有抑制剂的癌症的药物组合物。 在本发明的检测方法中，在来自女性生殖器的样品中检测到FGFR3融合蛋白或编码融合蛋白的融合基因或TACC3融合蛋白或编码融合蛋白的融合基因， 学科。
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公开(公告)号：US20150322498A1
公开(公告)日：2015-11-12
申请号：US14420635
申请日：2013-08-08
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Kengo TAKEUCHI
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12Q1/6806 , C12Q1/6823 , C12Q1/6841 , C12Q2563/107 , C12Q2565/1025 , C12Q2565/101
Abstract: Method for properly identifying and determining a target nucleic acid when the target nucleic acid is cleaved. The method includes a step of bringing a hybridization solution into contact with a target nucleic acid, wherein the hybridization solution contains a probe set that is composed of at least two labelled probes respectively labelled with different identifying factors and may hybridize with almost the full length of the sequence for the target nucleic acid. The method further includes a step of causing the identifying factors to develop the functions thereof to produce signals.
Abstract translation: 当靶核酸被切割时适当鉴定和确定靶核酸的方法。 该方法包括使杂交溶液与靶核酸接触的步骤，其中杂交溶液含有由至少两个分别用不同鉴定因子标记的标记的探针组成的探针组，并可与几乎全长的 靶核酸的序列。 该方法还包括使识别因子发展其功能以产生信号的步骤。
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公开(公告)号：US20040053278A1
公开(公告)日：2004-03-18
申请号：US10390553
申请日：2003-03-17
Applicant: Japanese Foundation for Cancer Research
Inventor： Kohei Miyazono , Masahiro Kawabata
IPC: C12Q001/68 , C07H021/04 , C07K014/475 , A61K038/24
CPC classification number: C07K14/4703 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
Abstract: The invention includes nucleic acids encoding the Smad6 protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products for using such nucleic acids and polypeptides also are provided.
Abstract translation: 本发明包括编码Smad6蛋白的核酸，包括其片段和生物功能变体。 还包括由这种核酸编码的多肽及其片段，以及与之相关的抗体。 还提供了使用这些核酸和多肽的方法和产品。
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Patent Agency Ranking
公开(公告)号：US20230407266A1
公开(公告)日：2023-12-21
申请号：US18239938
申请日：2023-08-30
Inventor： Yuki TAKAHASHI , Shiro KITANO , Ryohei KATAYAMA , Satoshi NAGAYAMA
IPC: C12N5/09
CPC classification number: C12N5/0693 , C12N2502/11 , C12N2502/1323 , C12N2502/28 , C12N2509/10 , C12N2513/00 , C12N2533/30 , C12N2533/90
Abstract: A primary culture method in which cells contained in a tissue collected from a living body are primary cultured in vitro, in which the cells in the tissue collected from the living body are seeded and cultured on a top surface of a cell structure containing cells constituting a stroma and composed of a single layer or two or more cell layers laminated in the thickness direction.
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公开(公告)号：US11817202B2
公开(公告)日：2023-11-14
申请号：US17474676
申请日：2021-09-14
Inventor： Takeshi Ohashi
CPC classification number: G16H30/20 , G02B21/365 , G06T3/0006 , G06T5/50 , G06T11/00 , A61B6/5217 , A61B6/5294 , G06T2207/20212
Abstract: Provided is an information processing apparatus including an image supply unit that supplies a plurality of input images showing corresponding objects to an image processing unit and obtains a plurality of object images as an image processed result from the image processing unit, and a display control unit that synchronously displays the plurality of object images that have been obtained. The object images are regions including the corresponding objects extracted from the plurality of input images, and orientations, positions, and sizes of the corresponding objects of the plurality of object images are unified.
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公开(公告)号：US20230045882A1
公开(公告)日：2023-02-16
申请号：US17788055
申请日：2020-12-25
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Noriko YAMAMOTO
IPC: G16H50/20 , G06V10/77 , G06V10/774 , G06V10/764 , G06V10/26 , G06V20/69 , G06V10/82 , G16H30/40 , G16H10/40
Abstract: Diagnosis is assisted by acquiring microscopical observation image data while specifying the position, classifying the image data into histological types with the use of AI, and reconstructing the classification result in a whole lesion. There is provided a pathological diagnosis assisting method that can provide an assistance technology which performs a pathological diagnosis efficiently with satisfactory accuracy by HE staining which is usually used by pathologists. Furthermore, there are provided a pathological diagnosis assisting system, a pathological diagnosis assisting program, and a pre-trained model.
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公开(公告)号：US11419871B2
公开(公告)日：2022-08-23
申请号：US17014011
申请日：2020-09-08
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Ryohei Katayama , Ken Uchibori , Naoya Fujita
IPC: A61K31/506 , A61K31/662 , G01N33/574 , C12Q1/68 , A61P35/00 , A61K45/06
Abstract: A drug containing, as an active ingredient, a compound represented by ALK inhibitors such as brigatinib, AP26113-analog, and AZD3463 has been found to be effective against a non-small cell lung cancer having a point mutation at C797S in EGFR which has acquired a resistance to chemotherapy agents. Further, the drug used in combination with an anti-EGFR antibody demonstrates a notable suppression effect on the tumor growth. The drug has a potential to be a therapeutic agent effective against a non-small cell lung cancer which is resistant to gefitinib, a first generation therapeutic agent and osimertinib, a third generation therapeutic agent.
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公开(公告)号：US11286261B2
公开(公告)日：2022-03-29
申请号：US16497917
申请日：2018-03-29
Inventor： Masatomo Iwao , Tsutomu Fukuda , Fumito Ishibashi , Yoshimasa Uehara , Naoyuki Nishiya , Yusuke Oku , Shingo Dan , Takao Yamori
IPC: C07D491/147
Abstract: Provided is a compound having a tyrosine kinase inhibitory activity specific to C797S resistant mutant EGFR (particularly C797S tertiary-resistant mutant EGFR) and is useful as a C797S resistant mutant EGFR (particularly C797S mutant tertiary-resistant EGFR) specific tyrosine kinase inhibitor, an agent for preventing and/or treating non-small cell lung cancer with resistance mutant EGFR and the like, and the like.
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